RD&E Research Repository: Recent submissions
Now showing items 21-40 of 2467
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Anti-interleukin-5 therapy in patients with severe asthma: from clinical trials to clinical practice
(Elsevier Science, 2020-05) -
A combined risk score enhances prediction of type 1 diabetes among susceptible children
(Nature Publishing Group, 2020-08)Type 1 diabetes (T1D)-an autoimmune disease that destroys the pancreatic islets, resulting in insulin deficiency-often begins early in life when islet autoantibody appearance signals high risk1. However, clinical diabetes ... -
A dynamical systems model for the measurement of cellular senescence
(Atypon, 2019-10-31)Senescent cells provide a good in vitro model to study ageing. However, cultures of 'senescent' cells consist of a mix of cell subtypes (proliferative, senescent, growth-arrested and apoptotic). Determining the proportion ... -
Breast pain: assessment, management, and referral criteria
(HighWire, 2020-07-30) -
Respiratory follow-up of patients with COVID-19 pneumonia
(HighWire, 2020-11)The COVID-19 pandemic has led to an unprecedented surge in hospitalised patients with viral pneumonia. The most severely affected patients are older men, individuals of black and Asian minority ethnicity and those with ... -
Expanding the phenotypic spectrum of IFT81: Associated ciliopathy syndrome
(Wiley, 2020-10)Short-rib polydactyly syndromes are a heterogeneous group of disorders characterized by narrow thorax with short ribs, polydactyly and often other visceral and skeletal malformations. To date there have only been six ... -
Machine Learning based histology phenotyping to investigate the epidemiologic and genetic basis of adipocyte morphology and cardiometabolic traits
(Public Library of Science, 2020-08-14)Genetic studies have recently highlighted the importance of fat distribution, as well as overall adiposity, in the pathogenesis of obesity-associated diseases. Using a large study (n = 1,288) from 4 independent cohorts, ... -
Applying gene-editing technology to elucidate the functional consequence of genetic and epigenetic variation in Alzheimer's disease
(Wiley, 2020-09)Recent studies have highlighted a potential role of genetic and epigenetic variation in the development of Alzheimer's disease. Application of the CRISPR-Cas genome-editing platform has enabled investigation of the functional ... -
The molecular etiology of Alzheimer's disease
(Wiley, 2020-09)Alzheimer's disease (AD) is a growing global healthcare epidemic. Owing to advances in technology, genome-scale studies of various layers of molecular information have been undertaken in recent years and robust variation ... -
Measuring quality of life in ALS/MND: validation of the WHOQOL-BREF
(Taylor & Francis, 2020-06-27)Objectives: The World Health Organization Quality of Life-BREF Scale (WHOQOL-BREF) is a generic QOL measure with four domains covering Physical, Psychological, Social and Environment. Providing the opportunity to contrast ... -
HCV infection and the risk of head and neck cancer: A meta-analysis
(Elsevier Science, 2020-06-26)Recent evidence has consistently suggested a role for HCV in the etiology of head and neck squamous cell carcinoma (HNSCC), but the conclusions of these studies have often been limited by small sample size. Therefore, a ... -
Remnant preservation does not affect accuracy of tibial tunnel positioning in single-bundle ACL reconstruction
(Springer, 2020-06-29)Purpose: Remnant preservation, in anterior cruciate ligament (ACL) reconstruction, has potential biological advantages. However, graft positioning remains vital to functional outcome and the prevention of failure. The aim ... -
Impact of comorbidity on the short- and medium-term risk of revision in total hip and knee arthroplasty
(BioMed Central, 2020-07-09)Background: The impact of comorbidity on the risk of revision in patients undergoing Total Knee arthroplasty (TKA) and Total Hip Arthroplasty (THA) is not currently well known. The aim of this study was to analyze the ... -
Critical analysis of quality of life and cost-effectiveness of enhanced recovery after surgery (ERAS) for patient's undergoing urologic oncology surgery: a systematic review
(Springer, 2020-07-09)Purpose: Enhanced recovery after surgery (ERAS) protocols have been implemented across a variety of disciplines to improve outcomes. Herein we describe the impact of ERAS on quality of life (QOL) and cost for patients ... -
Effect of clinical inertia and trial participation in younger and older adults with diabetes having comorbidities and progressive complications
(Elsevier Science, 2020-08)Aim: Clinical inertia is a multifactorial phenomenon, with contributing factors from people with diabetes and their healthcare team. It is widely cited that clinical inertia is minimised by participation in clinical trials. ... -
The effect of dietary nitrate supplementation on the speed-duration relationship in mice with sickle cell disease
(Atypon, 2020-09-01)Sickle cell disease (SCD) causes exercise intolerance likely due to impaired skeletal muscle function and low nitric oxide (NO) bioavailability. Dietary nitrate improves hemodynamic and metabolic control during exercise ... -
Psychiatric and neuropsychiatric syndromes and COVID-19
(Elsevier Science, 2020-08) -
Long-term evaluation of open-label pimavanserin safety and tolerability in Parkinson's disease psychosis
(Elsevier Science, 2020-08)Introduction: Pimavanserin is a selective 5-HT2A inverse agonist/antagonist approved for treating hallucinations and delusions associated with Parkinson's disease psychosis (PDP). Results from short-term, placebo-controlled ...