RD&E Research Repository: Recent submissions
Now showing items 21-40 of 1847
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Differences in risk of revision and mortality between total and unicompartmental knee arthroplasty: the influence of hospital volume
(Elsevier, 2019-05)The volume of arthroplasties performed in a hospital by year has an influence on the outcomes of total knee arthroplasty (TKA) and unicompartmental knee arthroplasty (UKA). The aims of this study are (1) to evaluate and ... -
Novel use of tranexamic acid to reduce the need for Nasal Packing in Epistaxis (NoPac) randomised controlled trial: research protocol
(BMJ, 2019-02-15)Patients presenting to emergency departments (EDs) with epistaxis uncontrolled by subsequent simple first aid measures or application of topical vasoconstrictors will typically undergo anterior nasal packing. Packing is ... -
European association for endoscopic surgery (EAES) consensus statement on single-incision endoscopic surgery
(Springer, 2019-04)Laparoscopic surgery changed the management of numerous surgical conditions. It was associated with many advantages over open surgery, such as decreased postoperative pain, faster recovery, shorter hospital stay and excellent ... -
Experiences of people with Parkinson's disease and their views on physical activity interventions: a qualitative systematic review
(Wolters Kluwer, 2019-04)The objective of the review was to synthesize the best available qualitative evidence on the experiences and preferences of people with Parkinson's disease for physical activity, their perceived motivators and barriers to ... -
Beta cells in type 1 diabetes: mass and function; sleeping or dead?
(Springer, 2019-04)Histological analysis of donor pancreases coupled with measurement of serum C-peptide in clinical cohorts has challenged the idea that all beta cells are eventually destroyed in type 1 diabetes. These findings have raised ... -
Partial diazoxide responsiveness in a neonate with hyperinsulinism due to homozygous ABCC8 mutation
(Bioscientifica, 2019-02-11)We report a case of partial diazoxide responsiveness in a child with severe congenital hyperinsulinaemic hypoglycaemia (CHI) due to a homozygous ABCC8 mutation. A term baby, with birth weight 3.8 kg, born to consanguineous ... -
Inflammatory bowel disease in children and adolescents.
(Canadian Medical Association, 2019-02-11) -
Validation of inertial measurement units with optical tracking system in patients operated with Total hip arthroplasty
(BioMed Central, 2019-02-06)Patient reported outcome measurement (PROMs) will not capture in detail the functional joint motion before and after total hip arthroplasty (THA). Therefore, methods more specifically aimed to analyse joint movements may ... -
A rare case of congenital hyperinsulinism (CHI) due to dual genetic aetiology involving HNF4A and ABCC8
(De Gruyter, 2019-03-26)Congenital hyperinsulinism (CHI) occurs due to an unregulated insulin secretion from the pancreatic β-cells resulting in hypoglycaemia. Causative mutations in multiple genes have been reported. Phenotypic variability exists ... -
Systematic review of definitions and outcome measures for return of bowel function after gastrointestinal surgery.
(Wiley, 2018-10)Ileus is common after gastrointestinal surgery and has been identified as a research priority. Several issues have limited previous research, including a widely accepted definition and agreed outcome measure. This review ... -
Phenotypic variability in two siblings with monogenic diabetes due to the same ABCC8 gene mutation
(Wiley, 2019-02-07)ABCC8 gene mutations with different inheritance patterns have been well described to cause transient and permanent forms of neonatal diabetes with onset of hyperglycaemia commonly before the age of 6 months, and rare cases ... -
De novo DDX3X missense variants in males appear viable and contribute to syndromic intellectual disability
(Wiley, 2019-04)DDX3X (Xp11.4) encodes a DEAD-box RNA helicase that escapes X chromosome inactivation. Pathogenic variants in DDX3X have been shown to cause X-linked intellectual disability (ID) (MRX102, MIM: 300958). The phenotypes ... -
Percutaneous consolidation of bone metastases: strategies and techniques
(Springer, 2019-02-06)Patients with cancer can present with bone metastases (BM), which are frequently complicated by different types of fractures necessitating prompt management to avoid serious impairment in terms of quality of life and ... -
Clinical Events After Deferral of LAD Revascularization Following Physiological Coronary Assessment
(Elsevier, 2019-02-05)Physicians are not always comfortable deferring treatment of a stenosis in the left anterior descending (LAD) artery because of the perception that there is a high risk of major adverse cardiac events (MACE). The authors ... -
Systemic agents for psoriasis and their relevance to primary care
(Royal College of General Practitioners, 2019-02)Psoriasis is a common chronic autoimmune inflammatory disease. There is an increasing range of systemic agents prescribed by specialists in the management of psoriasis. Thus, it is important for clinicians to become familiar ... -
What's in a smile? A review of the benefits of the clinician's smile
(BMJ, 2019-01-30)For millennia, the smile has been recognised as a powerful communication device, offering benefits to both giver and receiver with few drawbacks. A sign of compassion, empathy and friendliness, smiling can benefit healthcare ... -
Genetic risk variants for brain disorders are enriched in cortical H3K27ac domains
(BioMed Central, 2019-01)Most variants associated with complex phenotypes in genome-wide association studies (GWAS) do not directly index coding changes affecting protein structure. Instead they are hypothesized to influence gene regulation, with ... -
Peri-operative and oncological outcomes of radical prostatectomy for high-risk prostate cancer in the UK: an analysis of surgeon reported data
(Wiley, 2019-01-25)To analyse the peri-operative and oncological outcomes of all RPs performed for high risk prostate cancer(PCa) in the British Association of Urological Surgeons (BAUS) national registry from 2014-2015. -
Short-term results after laparoscopic repair of giant hiatal hernias with pledgeted sutures: a retrospective analysis
(Springer, 2019-01-25)Forty-one patients who underwent laparoscopic 270° Toupet fundoplication with pledgeted sutured crura between September 2014 and April 2017 were evaluated with regard to recurrence of hiatal hernia at 3 months and 1 year ...