RD&E Research Repository: Recent submissions
Now showing items 21-40 of 2073
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Rapid treatment of moderate to severe hypertension using a novel protocol in a single-centre, before and after interventional study
(Nature, 2019-10)Rapid treatment to target in hypertension may have beneficial effects on long-term outcomes. This has led to a new recommendation in the 2018 European hypertension guidelines for patients with grade II/III hypertension to ... -
A genome-wide association study implicates multiple mechanisms influencing raised urinary albumin-creatinine ratio
(Oxford Academic, 2019-10)Raised albumin-creatinine ratio (ACR) is an indicator of microvascular damage and renal disease. We aimed to identify genetic variants associated with raised ACR and study the implications of carrying multiple ACR-raising ... -
Genetic correlates of social stratification in Great Britain
(Nature, 2019-12)Human DNA polymorphisms vary across geographic regions, with the most commonly observed variation reflecting distant ancestry differences. Here we investigate the geographic clustering of common genetic variants that ... -
Examining the association between genetic liability for schizophrenia and psychotic symptoms in Alzheimer's Disease
(Nature, 2019-10)Psychosis (delusions or hallucinations) in Alzheimer's disease (AD + P) occurs in up to 50% of individuals and is associated with significantly worse clinical outcomes. Atypical antipsychotics, first developed for ... -
Disentangling the genetics of lean mass
(Oxford Academic, 2019-02)Lean body mass (LM) plays an important role in mobility and metabolic function. We previously identified five loci associated with LM adjusted for fat mass in kilograms. Such an adjustment may reduce the power to identify ... -
Benefits and harms of electrical neuromodulation for chronic pelvic pain: a systematic review
(Elsevier, 2019-10)Patients with chronic pelvic pain (CPP) may have pain refractory to conventional pain management strategies. Neuromodulation could provide relief of pain. -
Adherence and persistence to direct oral anticoagulants in atrial fibrillation: a population based study
(BMJ, 2020-01)Despite simpler regimens than vitamin K antagonists (VKAs) for stroke prevention in atrial fibrillation (AF), adherence (taking drugs as prescribed) and persistence (continuation of drugs) to direct oral anticoagulants are ... -
Raman spectroscopy for rapid intra-operative margin analysis of surgically excised tumour specimens
(Royal Society of Chemistry, 2019-11)Raman spectroscopy, a form of vibrational spectroscopy, has the ability to provide sensitive and specific biochemical analysis of tissue. This review article provides an in-depth analysis of the suitability of different ... -
Assessment of accuracy of an artificial intelligence algorithm to detect melanoma in images of skin lesions
(JAMA, 2019-10-02)A high proportion of suspicious pigmented skin lesions referred for investigation are benign. Techniques to improve the accuracy of melanoma diagnoses throughout the patient pathway are needed to reduce the pressure on ... -
Prospective evaluation of an ultrathin strut biodegradable polymer-coated sirolimus-eluting stent: 12 months' results from the S-FLEX UK registry
(BMJ, 2019-10)OBJECTIVE: To prospectively evaluate safety and efficacy of the ultrathin strut biodegradable polymer-coated Supraflex sirolimus-eluting stent (S-SES) in 'real world' patient population requiring percutaneous coronary ... -
HLA-DQA1*05 carriage associated with development of anti-drug antibodies to infliximab and adalimumab in patients with Crohn's Disease
(Elsevier, 2020-01)Anti-tumor necrosis factor (anti-TNF) therapies are the most widely used biologic drugs for treating immune-mediated diseases, but repeated administration can induce the formation of anti-drug antibodies. The ability to ... -
Determination of inclusion depth in ex vivo animal tissues using surface enhanced deep Raman spectroscopy
(Wiley, 2020-01)This work presents recent developments in spatially offset and transmission Raman spectroscopy for noninvasive detection and depth prediction of a single SERS inclusion located deep inside ex vivo biological tissues. The ... -
Diagnostic genetic testing for monogenic diabetes and congenital hyperinsulinemia
(Springer, 2020-01)Monogenic diabetes and hyperinsulinism are genetically heterogeneous disorders. The determination of the genetic etiology defines the diagnostic subtype, predicts prognosis, and importantly can guide clinical management. ... -
Measuring the effectiveness of safety warnings on the risk of stroke in older antipsychotic users: a nationwide cohort study in two large electronic medical records databases in the United Kingdom and Italy
(Springer, 2019-12)Safety warnings relating to antipsychotic-associated stroke among older persons in the UK and Italy were issued. However, the impact of these safety warnings on stroke risk has not been measured to date. -
Unravelling the genetic causes of mosaic islet morphology in congenital hyperinsulinism
(Wiley, 2019-10-02)Congenital hyperinsulinism (CHI) causes dysregulated insulin secretion which can lead to life-threatening hypoglycaemia if not effectively managed. CHI can be sub-classified into three distinct groups: diffuse, focal and ... -
Metaphyseal sleeves in revision total knee arthoplasty provide reliable fixation and excellent medium to long-term implant survivorship
(Elsevier, 2020-02)Addressing bone loss and securing implant fixation can be challenging in revision total knee arthroplasty (TKA). We present the results of a large series of revision TKAs using a metaphyseal sleeve.