RD&E Research Repository: Recent submissions
Now showing items 21-40 of 3493
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Robot-assisted laparoscopic repair of cesarean scar defect: a systematic review of clinical evidence
(Springer, 2022-11-27)We aim to assess the available evidence concerning the robot-assisted repair of cesarean scar defect. A systematic PubMed and Scopus search was conducted. All databases were assessed up to May 23, 2022. Studies reporting ... -
Portfolios in practice: Developing advancing practice within a musculoskeletal competency-based model
(Elsevier, 2022-11-13)INTRODUCTION: The development of professional portfolios and the relevance of this within professional practice, competency and capability is gaining significant credibility in line with professional requirements. Nursing ... -
A Rare Case of Open 3A VTB2W Periprosthetic Fracture around a Total Hip Arthroplasty
(Unknown, 2022-03-01)INTRODUCTION: The incidence of periprosthetic fracture (PPF) around a total hip arthroplasty (THA) continues to increase with the rise of number of THA performed. We present a rare case of a 73-year-old man who sustained ... -
EAES rapid guideline: systematic review, meta-analysis, GRADE assessment, and evidence-informed European recommendations on appendicitis in pregnancy
(Springer, 2022-12-01)BACKGROUND: Clinical practice recommendations for the management of acute appendicitis in pregnancy are lacking. OBJECTIVE: To develop an evidence-informed, trustworthy guideline on the management of appendicitis in ... -
Non-coding variants disrupting a tissue-specific regulatory element in HK1 cause congenital hyperinsulinism
(Nature, 2022-11-01)Gene expression is tightly regulated, with many genes exhibiting cell-specific silencing when their protein product would disrupt normal cellular function(1). This silencing is largely controlled by non-coding elements, ... -
UK consensus recommendations for clinical management of cancer risk for women with germline pathogenic variants in cancer predisposition genes: RAD51C, RAD51D, BRIP1 and PALB2
(BMJ, 2022-11-21)Germline pathogenic variants (GPVs) in the cancer predisposition genes BRCA1, BRCA2, MLH1, MSH2, MSH6, BRIP1, PALB2, RAD51D and RAD51C are identified in approximately 15% of patients with ovarian cancer (OC). While there ... -
Personalised 3D Printed high tibial osteotomy achieves a high level of accuracy: 'IDEAL' preclinical stage evaluation of a novel patient specific system
(Elsevier, 2022-10-01)High tibial osteotomy (HTO) is an effective surgical treatment for isolated medial compartment knee osteoarthritis; however, widespread adoption is limited due to difficulty in achieving the planned correction, and patient ... -
A narrative review of course evaluation methods for continuing professional development: The case of paediatric and neonatal acute-care in-service courses in low and lower-middle income countries: BEME Guide No. 76
(Taylor and Francis Group, 2022-11-11)BACKGROUND: Training a skilled healthcare workforce is an essential part in reaching the United Nations Sustainable Development Goal to end preventable deaths in children and neonates. The greatest burden of mortality lies ... -
Marathon running and cell-cycle arrest biomarkers of acute kidney injury
(Elsevier, 2022-10-24)OBJECTIVES: Endurance exercise is known to cause a rise in serum creatinine. It is not known to what extent this rise reflects renal stress and a potential acute kidney injury (AKI). Increases in Insulin Like Growth Factor ... -
Identifying type 1 and 2 diabetes in research datasets where classification biomarkers are unavailable: assessing the accuracy of published approaches
(Elsevier, 2022-11-08)OBJECTIVE: We aimed to compare the performance of approaches for classifying insulin treated diabetes within research datasets without measured classification biomarkers, evaluated against two independent biological ... -
Photodynamic versus white-light-guided resection of first-diagnosis non-muscle-invasive bladder cancer: PHOTO RCT
(NIHR Journals Library, 2022-10-01)BACKGROUND: Around 7500 people are diagnosed with non-muscle-invasive bladder cancer in the UK annually. Recurrence following transurethral resection of bladder tumour is common, and the intensive monitoring schedule ... -
Sarcoidosis: Updates on therapeutic drug trials and novel treatment approaches
(Frontiers Media, #VALUE!)Sarcoidosis is a systemic granulomatous inflammatory disease of unknown etiology. It affects the lungs in over 90% of patients yet extra-pulmonary and multi-organ involvement is common. Spontaneous remission of disease ... -
Safety of Same-Day Discharge Posterior Lumbar Decompression and/or Discectomy: An Observational Study Using Administrative Data From England
(Thieme, 2022-10-01)STUDY DESIGN: Retrospective cohort study. OBJECTIVES: Same-day discharge is widely used in many surgical specialities. If carefully planned, it can improve patient outcomes whilst using resources efficiently. We aimed to ... -
Importance of adopting standardized MANE transcripts in clinical reporting
(Nature, 2022-11-28) -
Plasma exchange and glucocorticoids to delay death or end-stage renal disease in anti-neutrophil cytoplasm antibody-associated vasculitis: PEXIVAS non-inferiority factorial RCT
(NIHR Journals Library, 2022-09-01)BACKGROUND: Anti-neutrophil cytoplasm antibody-associated vasculitis is a multisystem, autoimmune disease that causes organ failure and death. Physical removal of pathogenic autoantibodies by plasma exchange is recommended ... -
FOSL2 truncating variants in the last exon cause a neurodevelopmental disorder with scalp and enamel defects
(Nature, #VALUE!)PURPOSE: We aimed to investigate the molecular basis of a novel recognizable neurodevelopmental syndrome with scalp and enamel anomalies caused by truncating variants in the last exon of the gene FOSL2, encoding a subunit ... -
World Health Organization (WHO) International Classification of Functioning, Disability and Health (ICF) Core Set Development for Interstitial Lung Disease
(Frontiers Media, #VALUE!)Background: The World Health Organization (WHO) introduced the International Classification of Functioning, Disability, and Health (ICF) as a scientific method of disability data collection comprised of >1,200 categories ...