The everolimus eluting Synergy Megatron(TM) drug-eluting stent platform: Early outcomes from the European Synergy Megatron(TM) Implanters' Registry

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Authors
De Silva, K.
Li Kam Wa, M. E.
Wells, T.
Mozid, A.
Ladwiniec, A.
Hynes, B. G.
Kotecha, A.
Ratib, K.
Biswas, S.
Amabile, N.
Issue Date
2023-11-10
Type
Journal Article
Language
eng
Keywords
bifurcation , drug-eluting stent , left main
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BACKGROUND: The Synergy Megatron(TM) is an everolimus-drug eluting stent that may offer advantages in the treatment of aorto-ostial disease and large proximal vessels. AIMS: To report the short- to medium-term clinical outcomes from the European Synergy Megatron(TM) Implanters' Registry. METHODS: This registry was an investigator-initiated study conducted at 14 European centers. The primary outcome was target lesion failure (TLF), defined as the composite of cardiovascular death, target vessel myocardial infarction (MI), and target lesion revascularisation. RESULTS: Five hundred seventy-five patients underwent PCI with Megatron(TM) between 2019 and 2021. Patients were 69 ± 12 years old, 26% had diabetes mellitus, 24% had moderate-severe left ventricular impairment and 59% presented with an acute coronary syndrome. 15% were deemed prohibitively high risk for surgical revascularisation. The target vessel involved the left main stem in 55%, the ostium of the RCA in 13% and was a true bifurcation (Medina 1,1,1) in 50%.  At 1 year, TLF was observed in 40 patients, with 26 (65%) occurring within the first 30 days. The cumulative incidence of TLF was 4.5% at 30 days and 8.6% (95% CI 6.3-11.7) at 1 year. The incidence of stent thrombosis was 0.5% with no late stent thromboses. By multivariate analysis, the strongest independent predictors of TLF were severe left ventricular impairment (HR 3.43, 95% CI: 1.67-6.76, p < 0.001) and a target vessel involving the left main (HR 4.00 95% CI 1.81-10.15 p = 0.001). CONCLUSIONS: Use of the Synergy Megatron(TM) everolimus eluting stent in a 'real-world' setting shows favorable outcomes at 30 days and 1 year.
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Citation
De Silva K, Li Kam Wa ME, Wells T, Mozid A, Ladwiniec A, Hynes BG, et al. The everolimus eluting Synergy Megatron(TM) drug-eluting stent platform: Early outcomes from the European Synergy Megatron(TM) Implanters' Registry. Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions. 2023.
Publisher
Wiley
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© 2023 The Authors. Catheterization and Cardiovascular Interventions published by Wiley Periodicals LLC.
Journal
Catheterization and cardiovascular interventions
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