Successful transfer to sulfonylureas in KCNJ11 neonatal diabetes is determined by the mutation and duration of diabetes.

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Authors
Babiker, Tarig
Vedovato, N.
Patel, Kashyap
Thomas, Nicholas
Finn, Roisin
Männikkö, R.
Chakera, Ali J.
Flanagan, Sarah
Shepherd, Maggie
Ellard, Sian
Journal
Diabetologia
Type
Journal Article
Publisher
Springer
Rights
Archived with thanks to Diabetologia. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http:// creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made
The finding that patients with diabetes due to potassium channel mutations can transfer from insulin to sulfonylureas has revolutionised the management of patients with permanent neonatal diabetes. The extent to which the in vitro characteristics of the mutation can predict a successful transfer is not known. Our aim was to identify factors associated with successful transfer from insulin to sulfonylureas in patients with permanent neonatal diabetes due to mutations in KCNJ11 (which encodes the inwardly rectifying potassium channel Kir6.2).
Citation
Successful transfer to sulfonylureas in KCNJ11 neonatal diabetes is determined by the mutation and duration of diabetes. 2016 Jun;59(6):1162-6
Note
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