Urine C-peptide creatinine ratio can be used to assess insulin resistance and insulin production in people without diabetes: an observational study.

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Authors
Oram, Richard A.
Rawlingson, Andrew
Shields, Beverley M
Bingham, Coralie
Besser, R.
McDonald, Timothy J.
Knight, Bridget A.
Hattersley, Andrew T.
Journal
BMJ open
Type
Journal Article
Observational Study
Publisher
BMJ
Rights
Archived with thanks to BMJ open
The current assessment of insulin resistance (IR) in epidemiology studies relies on the blood measurement of C-peptide or insulin. A urine C-peptide creatinine ratio (UCPCR) can be posted from home unaided. It is validated against serum measures of the insulin in people with diabetes. We tested whether UCPCR could be a surrogate measure of IR by examining the correlation of UCPCR with serum insulin, C-peptide and HOMA2 (Homeostasis Model Assessment 2)-IR in participants without diabetes and with chronic kidney disease (CKD).
Citation
Urine C-peptide creatinine ratio can be used to assess insulin resistance and insulin production in people without diabetes: an observational study. 2013, 3 (12):e003193 BMJ Open
Note
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