The Effect of Dysglycaemia on Changes in Pulmonary and Aerobic Function in Cystic Fibrosis

dc.contributor.authorTomlinson, O. W.
dc.contributor.authorStoate, A. L. E.
dc.contributor.authorDobson, L.
dc.contributor.authorWilliams, C. A.
dc.description.abstractCross-sectional studies have reported lower pulmonary and aerobic function during exercise in people with cystic fibrosis-related diabetes (CFRD) compared to non-CFRD counterparts. However, this association has yet to be longitudinally investigated. Therefore, this study examines these differences over time between people with cystic fibrosis (CF) of differing glycaemic status. Annual review data, including cardiopulmonary exercise tests and pulmonary function tests, were retrospectively analysed at baseline (T0, n = 82) and at a one-year follow-up (T1, n = 54). Data was analysed in three groups: normal glucose tolerance (NGT), impaired glucose tolerance (IGT), and CFRD. Further analyses were undertaken, with a dichotomous split of NGT and a combined IGT/CFRD group. At baseline, a significant reduction in the majority of variables, including forced expiratory volume in one second (FEV(1)) and maximal oxygen uptake (VO(2max)), was observed in the CFRD (n = 19) group compared to NGT (n = 58). At follow-up, no significant differences were observed, and no interaction effect between CFRD status and time was identified. FEV(1) and VO(2max) presented with varying directions and magnitudes of change within patients. In summary, patients with CFRD have a reduced aerobic and pulmonary function compared to non-CFRD counterparts, although such changes disappeared at follow up. Varying responses for FEV(1) and VO(2max) highlight the need to consider both variables as independent markers of function in CF.
dc.description.admin-notePublished version, accepted version, submitted version
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dc.identifier.citationFront Physiol. 2022 Mar 30;13:834664. doi: 10.3389/fphys.2022.834664. eCollection 2022.
dc.identifier.journalFrontiers in physiology
dc.publisherFrontiers Media
dc.rightsCopyright © 2022 Tomlinson, Stoate, Dobson and Williams.
dc.subjectcardiorespiratory fitness
dc.subjectcystic fibrosis related diabetes
dc.subjectlongitudinal data
dc.subjectoxygen uptake
dc.subjectpulmonary disease
dc.titleThe Effect of Dysglycaemia on Changes in Pulmonary and Aerobic Function in Cystic Fibrosis
dc.typeJournal Article