Is disrupted sleep a risk factor for Alzheimer's disease? Evidence from a two-sample Mendelian randomization analysis

dc.contributor.authorJones, S. E.
dc.contributor.authorBeaumont, Robin N.
dc.contributor.authorTyrrell, Jessica
dc.contributor.authorFrayling, Timothy M.
dc.contributor.authorWood, A. R.
dc.contributor.authorWeedon, M. N.
dc.date.accessioned2021-06-29T10:21:00Z
dc.date.available2021-06-29T10:21:00Z
dc.date.issued2020-11-05
dc.description.abstractBackground: It is established that Alzheimer's disease (AD) patients experience sleep disruption. However, it remains unknown whether disruption in the quantity, quality or timing of sleep is a risk factor for the onset of AD. Methods: We used the largest published genome-wide association studies of self-reported and accelerometer-measured sleep traits (chronotype, duration, fragmentation, insomnia, daytime napping and daytime sleepiness), and AD. Mendelian randomization (MR) was used to estimate the causal effect of self-reported and accelerometer-measured sleep parameters on AD risk. Results: Overall, there was little evidence to support a causal effect of sleep traits on AD risk. There was some suggestive evidence that self-reported daytime napping was associated with lower AD risk [odds ratio (OR): 0.70, 95% confidence interval (CI): 0.50-0.99). Some other sleep traits (accelerometer-measured 'eveningness' and sleep duration, and self-reported daytime sleepiness) had ORs of a similar magnitude to daytime napping, but were less precisely estimated. Conclusions: Overall, we found very limited evidence to support a causal effect of sleep traits on AD risk. Our findings provide tentative evidence that daytime napping may reduce AD risk. Given that this is the first MR study of multiple self-report and objective sleep traits on AD risk, findings should be replicated using independent samples when such data become available.en_US
dc.description.admin-notepublished version, accepted version (12 month embargo), submitted versionen_US
dc.description.fundingD.A.L. has received funding from numerous national and international government and charitable funders and Medtronic Ltd and Roche Diagnostics for work unrelated to that presented here. All other authors state they have no competing interests to discloseen_US
dc.description.noteThis article is available to RD&E staff via NHS OpenAthens. Click on the Publisher URL, and log in with NHS OpenAthens if prompted.en_US
dc.identifier.citationAnderson EL et al. Is disrupted sleep a risk factor for Alzheimer's disease? Evidence from a two-sample Mendelian randomization analysis. Int J Epidemiol. 2020 Nov 5:dyaa183. doi: 10.1093/ije/dyaa183. Epub ahead of print.en_US
dc.identifier.doi10.1093/ije/dyaa183
dc.identifier.journalInternational Journal of Epidemiologyen_US
dc.identifier.pmid33150399
dc.identifier.urihttps://hdl.handle.net/11287/621796
dc.language.isoenen_US
dc.publisherSilverchairen_US
dc.relation.urlhttps://academic.oup.com/ije/article-lookup/doi/10.1093/ije/dyaa183en_US
dc.rightsVC The Author(s) 2020. Published by Oxford University Press on behalf of the International Epidemiological Association. 1 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.en_US
dc.rightsCC0 1.0 Universal*
dc.rights.urihttp://creativecommons.org/publicdomain/zero/1.0/*
dc.subjectAlzheimer’s diseaseen_US
dc.subjectMendelian randomizationen_US
dc.subjectSleepen_US
dc.subjectcausal inferenceen_US
dc.subjectdementiaen_US
dc.subjectWessex Classification Subject Headings::Oncology. Pathology.::Geneticsen_US
dc.titleIs disrupted sleep a risk factor for Alzheimer's disease? Evidence from a two-sample Mendelian randomization analysisen_US
dc.typeJournal Articleen_US
dc.type.versionPublisheden_US
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