Welcome to The Royal Devon Research Repository
The Royal Devon Research Repository contains research outputs from staff at the Royal Devon University Healthcare NHS Foundation Trust.
You can browse items by Title, Author, Subject or Community/Collection, or use the search function to find specific topics.
The repository contains details of published, peer-reviewed journal articles, reviews, book chapters, conference abstracts and posters. Full-text of journal articles have been included where publisher's permissions allow.
If you are a member of Royal Devon University Healthcare NHS Foundation Trust and you'd like to submit an item to the repository, please fill in this online form. If you have a list of publications you'd like to submit, please e-mail the repository admin team: rde - tr.ResearchRepository@nhs.net.
For more information or help, please contact The Royal Devon Research Repository admin team:
Email: rde - tr.ResearchRepository@nhs.net
Telephone: Exeter Health Library, 01392 406800
Recent Submissions
Item type:Item, Impact of a Digital Leakage Notification System on Leakage, Quality of Life, Healthcare Resource Utilisation, and Work Productivity: Interim Results from a Longitudinal Real-World Study in the UK(MDPI, 2026-01-14)Background: Leakage is a major concern for individuals living with a stoma and may negatively impact quality of life (QoL). A digital leakage notification system (DLNS) recently launched in the UK provides timely notifications to users via their smartphone when faeces is detected underneath the baseplate. This provides predictability and enables users to take proactive measures to help avoid leakages outside the baseplate. Methods: A single-arm, observational, longitudinal study of the DLNS, including its associated support service, has been initiated to follow 300 users for a year in the UK to evaluate long-term health benefits of the DLNS and its implications for healthcare resource utilisation in a real-world setting. The DLNS is prescribed by healthcare professionals (HCPs), and all users were invited to participate in the study. Study participants complete questionnaires capturing data on QoL (using the Ostomy Leak Impact tool), number of leakages outside the baseplate, utilisation of ostomy products, interactions with HCPs, and work productivity (using the Work Productivity and Activity Impairment questionnaire) at baseline and then every third month for one year. Data from the planned interim analysis of the first 100 participants who had been in the study for 6 months is presented. Results: Use of the DLNS for 6 months together with the associated support service was associated with a 51% reduction in leakage episodes outside the baseplate (p < 0.001) and great improvements in QoL (p < 0.001). Use of the DLNS reduced the number of unplanned baseplate changes due to worry about leakage by 47% (p < 0.001) and overall was associated with a reduction in the number of baseplates used by 14% (p = 0.002). Total time spent with HCPs related to stoma care was reduced by 65% after 6 months compared with baseline (p < 0.001). Work absenteeism and presenteeism improved significantly with the use of the DLNS. Conclusions: The interim results of this prospective, longitudinal study provided first insights into the long-term benefits of the DLNS in a real-world setting. ClinicalTrials.gov ID: NCT06554015.Item type:Item, Mapping EQ-5D-5L utility scores from the severe asthma questionnaire in the SHARP CRC registry(Elsevier, 2026-03-04)BACKGROUND: Severe asthma imposes a substantial burden on individuals' health-related quality of life (HRQoL), which might not be fully captured by generic instruments. The Severe Asthma Questionnaire (SAQ) is a validated disease-specific HRQoL instrument capturing the unique lived experience of people with severe asthma. However, the SAQ does not generate preference-based utility values required for health economic evaluations. This study aimed to develop and validate mapping algorithms from the SAQ to the EuroQol (EQ)-5D-5L, enabling estimation of utility values when EQ-5D data are unavailable. METHODS: We used baseline and 6-month data from the longitudinal, multicentre SHARP Burden of Asthma study, including adults with severe asthma across 7 European countries. Direct mapping (ordinary least squares and beta-mixture regression models) using the UK value set and indirect mapping (ordered probit regression models) were developed with baseline data to predict EQ-5D-5L utility values from SAQ scores. Performance was assessed via mean absolute error (MAE), root mean square error (RMSE), and R(2), with 6-month data used for validation. RESULTS: Data from 327 patients were included. The beta-mixture model using SAQ subscales marginally outperformed the other models in the development set (MAE = 0.090, RMSE = 0.129, R(2) = 0.704), whereas in the validation set the ordered probit regression model showed the best predictive performance (MAE = 0.106, RMSE = 0.151, R(2) = 0.589). CONCLUSIONS: Direct mapping with beta-mixture regression showed good overall performance, aligning with prior studies. Indirect mapping may be advantageous in settings requiring flexibility across EQ-5D-5L value sets. These findings demonstrate that EQ-5D-5L utility values can be reliably estimated from the SAQ, supporting use of the instrument in health-economic analyses.Item type:Item, Patient-reported experience measure (PREM) for patients with interstitial lung disease (ILD): modification of a pre-existing measure(BMJ Publishing Group, 2026-01-20)OBJECTIVE: Patient-reported experience measures (PREMs) are a key component of healthcare accountability frameworks, health policy, integrated care board commissioning and integrated care partnerships generating data which are crucial markers of patient care quality. The Rheumatoid Arthritis Patient-Reported Experience Measure (RA-PREM) incorporates the eight core elements of NHS Patient Experience Framework and is validated in a range of rheumatic conditions. Our objective is to determine the acceptability and feasibility of the RA-PREM for an interstitial lung disease (ILD) population. DESIGN: A mixed-methods patient-centred approach incorporating an interdisciplinary research steering group with patient partners. Patient surveys evaluated the language and meaning of the RA-PREM 8 domains, 24 statements and response categories. A patient focus group examined contentious statements. A consensus group of expert patient-partners agreed statements for the modified RA-PREM. Focus group participants reviewed the modified instrument (ILD-PREM) for acceptability and face/content validity. SETTING: A single NHSE-commissioned, regional ILD service/UK. RESULTS: Thirteen patients (10 male) diagnosed with ILD participated in focus group discussions. Critical discussion of the RA-PREM resulted in nuanced modifications of four statements of three domains. Five patients (three male) and three healthcare researchers attained consensus on the face/content validity of statements. Seventy-three patients completed the ILD-PREM following outpatient contact. CONCLUSION: The ILD-PREM retains 24 statements representing the eight domains of the RA-PREM. It meets face/content validity criteria and is acceptable to an ILD population. Longitudinal validation of the ILD-PREM across ILD services including further testing in global minority groups will establish criterion and construct validity and objective measures of reliability.Item type:Item, Candida in the lung: Fact, fiction, friend or foe?(Plos, 2026-03-01)Item type:Item, Assessment of Increased Quadriceps Angle as a Risk Factor for Anterior Cruciate Ligament Injury(West African College of Surgeons, 2026-01-01)INTRODUCTION: Anterior cruciate ligament (ACL) injury results in chronic knee instability and early development of knee osteoarthritis. Increased Q angle has been postulated as a risk factor for ACL injury. Individuals at risk of sustaining ACL injuries would benefit from participating in injury prevention programmes. AIM: To compare the mean value of the Q angle in adult participants with and without ACL injury. MATERIALS AND METHODS: This was a hospital-based case-control study comprised of 56 patients divided into two matched groups. Q angle was measured in both knees, following the same surface goniometry measurement protocol. An independent sample t-test was used to compare the means of the measured Q angle between cases and controls. RESULTS: The difference in the measured Q angle between the ACL-injured group and the non-ACL-injured group was found to be statistically significant, with those in the ACL-injured group having higher values in standing and supine positions (12.73 ± 1.5° vs. 11.40 ± 1.5° and 12.32 ± 1.2° vs. 11.07 ± 1.4°) with a P value of <0.001. CONCLUSION: Individuals with ACL injury in our population of Black patients have a significantly greater Q angle than those without ACL injury when measured in the standing and supine positions using surface goniometry.
Communities in Royal Devon Research Repository
Select a community to browse its collections.