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dc.contributor.authorHanon, Eilis
dc.contributor.authorMill, Jonathan
dc.contributor.authorLunnon, Katie
dc.date.accessioned2019-05-31T14:53:29Z
dc.date.available2019-05-31T14:53:29Z
dc.date.issued2019-03
dc.identifier.citationSmith AR [et al]. Parallel profiling of DNA methylation and hydroxymethylation highlights neuropathology-associated epigenetic variation in Alzheimer's disease. Clinical Epigenetics. 2019 Mar 21;11(1):52en_US
dc.identifier.pmid30898171
dc.identifier.doi10.1186/s13148-019-0636-y
dc.identifier.urihttps://rde.dspace-express.com/handle/123456789/621018
dc.description.abstractAlzheimer's disease is a progressive neurodegenerative disorder that is hypothesized to involve epigenetic dysfunction. Previous studies of DNA modifications in Alzheimer's disease have been unable to distinguish between DNA methylation and DNA hydroxymethylation. DNA hydroxymethylation has been shown to be enriched in the human brain, although its role in Alzheimer's disease has not yet been fully explored. Here, we utilize oxidative bisulfite conversion, in conjunction with the Illumina Infinium Human Methylation 450K microarray, to identify neuropathology-associated differential DNA methylation and DNA hydroxymethylation in the entorhinal cortex.en_US
dc.language.isoenen_US
dc.publisherBioMed Centralen_US
dc.relation.urlhttps://clinicalepigeneticsjournal.biomedcentral.com/articles/10.1186/s13148-019-0636-yen_US
dc.subjectWessex Classification Subject Headings::Oncology. Pathology.::Geneticsen_US
dc.titleParallel profiling of DNA methylation and hydroxymethylation highlights neuropathology-associated epigenetic variation in Alzheimer's diseaseen_US
dc.typeJournal Articleen_US
dc.identifier.journalClinical Epigeneticsen_US
dc.description.noteThis article is freely available via Open Access. Click on the Publisher's URL to access to full-text.en_US
dc.type.versionPublisheden_US
dc.description.admin-noteOpen Accessen_US


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