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    Persistence of clinically relevant levels of SARS-CoV2 envelope gene subgenomic RNAs in non-immunocompromised individuals

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    URI
    https://rde.dspace-express.com/handle/11287/622351
    Author
    Davies, M.
    Bramwell, L. R.
    Jeffery, N.
    Bunce, B.
    Lee, B. P.
    Knight, B.
    Auckland, C.
    Masoli, J. A.
    Harries, L. W.
    Date
    2021-12-07
    Journal
    International journal of infectious diseases
    Type
    Journal Article
    Publisher
    Elsevier
    DOI
    10.1016/j.ijid.2021.12.312
    Rights
    Copyright © 2021. Published by Elsevier Ltd.
    Metadata
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    Abstract
    OBJECTIVES: This study aimed to evaluate the associations between COVID-19 severity and active viral load, and to characterize the dynamics of active SARS-CoV-2 clearance in a series of archival samples taken from patients in the first wave of COVID-19 infection in the South West of the UK. METHODS: Subgenomic RNA (sgRNA) and E-gene genomic sequences were measured in a retrospective collection of PCR-confirmed SARS-CoV-2-positive samples from 176 individuals, and related to disease severity. Viral clearance dynamics were then assessed in relation to symptom onset and last positive test. RESULTS: Whilst E-gene sgRNAs declined before E-gene genomic sequences, some individuals retained sgRNA positivity for up to 68 days. 13% of sgRNA-positive cases still exhibited clinically relevant levels of virus after 10 days, with no clinical features previously associated with prolonged viral clearance times. CONCLUSIONS: Our results suggest that potentially active virus can sometimes persist beyond a 10-day period, and could pose a potential risk of onward transmission. Where this would pose a serious public health threat, additional mitigation strategies may be necessary to reduce the risk of secondary cases in vulnerable settings.
    Citation
    Int J Infect Dis. 2021 Dec 7:S1201-9712(21)01206-6. doi: 10.1016/j.ijid.2021.12.312.
    Publisher URL
    https://www.ijidonline.com/article/S1201-9712(21)01206-6/fulltext
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    RD&E staff can access the full-text of this article by clicking on the 'Additional Link' above and logging in with NHS OpenAthens if prompted.
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    • 2021 RD&E publications
    • COVID-19
    • Genetics and genomics

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