Now showing items 1-2 of 2

    • Disease consequences of higher adiposity uncoupled from its adverse metabolic effects using Mendelian randomisation 

      Martin, S.; Tyrrell, J.; Thomas, E. L.; Bown, M. J.; Wood, A. R.; Beaumont, R. N.; Tsoi, L. C.; Stuart, P. E.; Elder, J. T.; Law, P.; Houlston, R.; Kabrhel, C.; Papadimitriou, N.; Gunter, M. J.; Bull, C. J.; Bell, J. A.; Vincent, E. E.; Sattar, N.; Dunlop, M. G.; Tomlinson, I. P.; Bell, J. D.; Frayling, T. M.; Yaghootkar, H. (eLife Sciences Publications Ltd., 2022-01-25)
      BACKGROUND: Some individuals living with obesity may be relatively metabolically healthy, whilst others suffer from multiple conditions that may be linked to adverse metabolic effects or other factors. The extent to which ...
    • Statin treatment effectiveness and the SLCO1B1*5 reduced function genotype: Long-term outcomes in women and men 

      Türkmen, D.; Masoli, J. A. H.; Kuo, C. L.; Bowden, J.; Melzer, D.; Pilling, L. C. (Wiley, 2022-01-26)
      OBJECTIVE: To estimate the effect of rs4149056 (SLCO1B1*5) genotype (decreases statin transport) on cholesterol control and treatment duration in male and female primary care patients prescribed common statin medications. ...