• Ambulatory care management of 69 patients with acute severe ulcerative colitis in comparison to 695 inpatients: insights from a multicentre UK cohort study 

  Sebastian, S.; Patel, K. V.; Segal, J. P.; Subramanian, S.; Conley, T. E.; Gonzalez, H. A.; Kent, A. J.; Saifuddin, A.; Hicks, L.; Mehta, S.; Bhala, N.; Brookes, M. J.; Lamb, C. A.; Kennedy, N. A.; Walker, G. J. (BMJ Publishing Group, 2022-01-01)

  INTRODUCTION: Acute severe ulcerative colitis (ASUC) traditionally requires inpatient hospital management for intravenous therapies and/or colectomy. Ambulatory ASUC care has not yet been evaluated in large cohorts. AIMS: ...

• Is rationing of total hip arthroplasty justified? Working to optimize patient accessibility to surgery using long-term patient-reported outcome data 

  Walker, R. W.; Whitehouse, S. L.; Howell, J. R.; Hubble, M. J. W.; Timperley, A. J.; Wilson, M. J.; Kassam, A. M. (British Editorial Society of Bone and Joint Surgery, 2022-03-01)

  AIMS: The aim of this study was to assess medium-term improvements following total hip arthroplasty (THA), and to evaluate what effect different preoperative Oxford Hip Score (OHS) thresholds for treatment may have on ...

• Tibial tuberosity-trochlear groove distance: does it measure up? 

  Krishnan, H.; Eldridge, J. D.; Clark, D.; Metcalfe, A. J.; Stevens, J. M.; Mandalia, V. (British Editorial Society of Bone and Joint Surgery, 2022-03-24)

  Recognized anatomic variations that lead to patella instability include patella alta and trochlea dysplasia. Lateralization of the extensor mechanism relative to the trochlea is often considered to be a contributing factor; ...

• Statin treatment effectiveness and the SLCO1B1*5 reduced function genotype: Long-term outcomes in women and men 

  Türkmen, D.; Masoli, J. A. H.; Kuo, C. L.; Bowden, J.; Melzer, D.; Pilling, L. C. (Wiley, 2022-01-26)

  OBJECTIVE: To estimate the effect of rs4149056 (SLCO1B1*5) genotype (decreases statin transport) on cholesterol control and treatment duration in male and female primary care patients prescribed common statin medications. ...

• Rapid, patient-led titration of basal insulin can be used to achieve tight glycaemic control in gestational diabetes mellitus with insulin resistance 

  Mayne, I.; Thomas, N.; McGovern, A. (BMJ, 2022-03-10)

  A woman with gestational diabetes mellitus (GDM) and significant insulin resistance in her third pregnancy was diagnosed with a fasting blood glucose reading of 5.7 mmol/L (103 mg/dL) at 28+1 weeks gestation and referred ...

• Bickerstaff brainstem encephalitis: clinical, neurophysiological, laboratory and postmortem findings of a case presenting as encephalomyelitis 

  Imam, I.; Sarrigiannis, P. G.; Shivane, A. G. (BMJ, 2022-02-02)

  Our patient was admitted to hospital with a 1-week history of an upper respiratory tract infection and a rapidly progressive encephalopathy dominated by brainstem features and widespread areflexia. Her antiganglioside ...

• The benefits of virtual learning webinars to both low- and high-income countries 

  Ng, M.; Chamileke, N.; Mapulanga, V.; Campain, N.; Payne, S. (Wiley, 2022-04-01)

  The coronavirus disease 2019 (COVID-19) pandemic has brought about many changes in the relationships between high-income countries and partner organisations in low- or low-middle-income countries, such as predominate in ...

• Peritoneal bacteria contamination and endometriosis pathogenesis 

  Iavazzo, C.; Vrachnis, N.; Gkegkes, I. D. (Springer, 2022-02-22)

• THUMPD1 bi-allelic variants cause loss of tRNA acetylation and a syndromic neurodevelopmental disorder 

  Broly, M.; Polevoda, B. V.; Awayda, K. M.; Tong, N.; Lentini, J.; Besnard, T.; Deb, W.; O'Rourke, D.; Baptista, J.; Ellard, S.; Almannai, M.; Hashem, M.; Abdulwahab, F.; Shamseldin, H.; Al-Tala, S.; Alkuraya, F. S.; Leon, A.; van Loon, R. L. E.; Ferlini, A.; Sanchini, M.; Bigoni, S.; Ciorba, A.; van Bokhoven, H.; Iqbal, Z.; Al-Maawali, A.; Al-Murshedi, F.; Ganesh, A.; Al-Mamari, W.; Lim, S. C.; Pais, L. S.; Brown, N.; Riazuddin, S.; Bézieau, S.; Fu, D.; Isidor, B.; Cogné, B.; O'Connell, M. R. (Cell Press, 2022-02-11)

  Covalent tRNA modifications play multi-faceted roles in tRNA stability, folding, and recognition, as well as the rate and fidelity of translation, and other cellular processes such as growth, development, and stress ...

• Is there a role for botulinum toxin A in the emergency setting for delayed abdominal wall closure in the management of the open abdomen? A systematic review 

  Luton, O. W.; Mortimer, M.; Hopkins, L.; Robinson, D.; Egeler, C.; Smart, N. J.; Harries, R. (Royal College of Surgeons, 2022-02-17)

  INTRODUCTION: Emergency laparotomy for either trauma or non-trauma indications is common and management is varied. Use of the open abdomen technique allowing for planned re-look is an option; however, performing delayed ...

• Clinician preferences in the treatment of acutely symptomatic hernia: the 'MASH' survey 

  O'Connor, O. M.; Burns, F. A.; Proctor, V. K.; Green, S. K.; Sayers, A. E.; Smart, N. J.; Lee, M. J. (Royal College of Surgeons, 2022-02-23)

  INTRODUCTION: There is limited high-quality evidence to guide the management of acute hernia presentation. The aim of this study was to survey surgeons to assess current trends in assessment, treatment strategy and operative ...

• Elective splenectomy in patients with non-Hodgkin lymphoma: Does the size of the spleen affect surgical outcomes? 

  Mauro, D. D.; Gelsomino, M.; Fasano, A.; Wajed, S.; Manzelli, A. (Korean Association of Hepato-Biliary-Pancreatic Surgery, 2022-02-16)

  BACKGROUNDS/AIMS: Splenectomy in patients with non-Hodgkin lymphoma (NHL) is performed to relieve abdominal symptoms, treat hypersplenism or confirm diagnosis. Excision of a very large spleen is technically challenging and ...

• What is new in migraine management in children and young people? 

  Loh, N. R.; Whitehouse, W. P.; Howells, R. (BMJ, 2022-02-21)

  For this narrative review, we found recent publications on the use and effectiveness of old therapies including nutraceuticals, such as riboflavin, vitamin D, magnesium, melatonin and talking therapies. Recent large trials ...

• Dislocation of the hip after normal sonographic screening examination: a case report and literature review 

  Walton, T. J.; Chatterton, B. D.; Dover, C.; Kiely, N. T. (Royal College of Surgeons, 2022-02-17)

  We report the case of a five-month-old girl presenting with a subluxed left hip following normal neonatal clinical examination and serial ultrasound screening. Her only risk factor for developmental dysplasia of the hip ...

• 811 DELIRIUM IN COVID-19: COMMON AND CLINICALLY SIGNIFICANT: EXPERIENCES FROM THE NIGHTINGALE HOSPITAL EXETER 

  Reed, W; Fearnley, C; Tregarthen, A; Hubbard, J; Griffiths, J; Whitehead, T; Hacon, J; Anning, L (Oxford University Press, 2022-03-08)

  Delirium is an independent predictor of mortality in patients admitted with community-acquired pneumonia (Pieralli, 2014), but significance and incidence in Covid-19 infection has not been established. The Nightingale ...

• Postradioiodine Graves' management: The PRAGMA study 

  Perros, P.; Basu, A.; Boelaert, K.; Dayan, C.; Vaidya, B.; Williams, G. R.; Lazarus, J. H.; Hickey, J.; Drake, W. M.; Crown, A.; Orme, S. M.; Johnson, A.; Ray, D. W.; Leese, G. P.; Jones, T. H.; Abraham, P.; Grossman, A.; Rees, A.; Razvi, S.; Gibb, F. W.; Moran, C.; Madathil, A.; Žarković, M. P.; Plummer, Z.; Jarvis, S.; Falinska, A.; Velusamy, A.; Sanderson, V.; Pariani, N.; Atkin, S. L.; Syed, A. A.; Sathyapalan, T.; Nag, S.; Gilbert, J.; Gleeson, H.; Levy, M. J.; Johnston, C.; Sturrock, N.; Bennett, S.; Mishra, B.; Malik, I.; Karavitaki, N. (Wiley, 2022-03-11)

  OBJECTIVE: Thyroid status in the months following radioiodine (RI) treatment for Graves' disease can be unstable. Our objective was to quantify frequency of abnormal thyroid function post-RI and compare effectiveness of ...

• Evaluation of Evidence for Pathogenicity Demonstrates that BLK, KLF11 and PAX4 Should not be Included in Diagnostic Testing for MODY 

  Laver, T. W.; Wakeling, M. N.; Knox, O.; Colclough, K.; Wright, C. F.; Ellard, S.; Hattersley, A. T.; Weedon, M. N.; Patel, K. A. (American Diabetes Association, 2022-02-02)

  Maturity Onset Diabetes of the Young (MODY) is an autosomal dominant form of monogenic diabetes, reported to be caused by variants in 16 genes. Concern has been raised about whether variants in BLK (MODY11), KLF11 (MODY7) ...

• Bronchiolitis 

  Gill, P. J.; Chanchlani, N.; Mahant, S. (Canadian Medical Association, 2022-02-14)

• X-linked Ohdo syndrome due to a novel MED12 variant detected by Rapid Exome Sequencing 

  McDermott, H.; Garikapati, V.; Baptista, J.; Gowda, H.; Naik, S. (Wolters Kluwer, 2022-04-01)

• 266 Improving Management of Women Presenting with Groin Hernias at Royal Devon and Exeter Hospital (RD&E) 

  Chillarge, G. (Wiley, 2022-02-28)

  Determine the percentage of women with groin hernia undergoing laparoscopic repair at RD&E hospital and if it was offered during clinic visit.The lifetime risk of groin hernia in women is 3–5.8%. The incidence of missed ...

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