• Hospital admissions from alcohol-related acute pancreatitis during the COVID-19 pandemic: A single-centre study 

  Mak, W. K.; Di Mauro, D.; Pearce, E.; Karran, L.; Myintmo, A.; Duckworth, J.; Orabi, A.; Lane, R.; Holloway, S.; Manzelli, A.; Mossadegh, S. (IS Publishing, 2022-09-06)

  BACKGROUND: The United Kingdom government introduced lockdown restrictions for the first time on 23 March 2020 due to coronavirus disease 2019 (COVID-19) pandemic. These were partially lifted on 15 June and further eased ...

• Using simulation and machine learning to maximise the benefit of intravenous thrombolysis in acute stroke in England and Wales: the SAMueL modelling and qualitative study 

  Allen, M.; James, C.; Frost, J.; Liabo, K.; Pearn, K.; Monks, T.; Zhelev, Z.; Logan, S.; Everson, R.; James, M.; Stein, K. (NIHR Journals Library, 2022-10-01)

  BACKGROUND: Stroke is a common cause of adult disability. Expert opinion is that about 20% of patients should receive thrombolysis to break up a clot causing the stroke. Currently, 11–12% of patients in England and Wales ...

• EFSUMB Clinical Practice Guidelines for Point-of-Care Ultrasound: Part One (Common Heart and Pulmonary Applications) SHORT VERSION 

  Jarman, R. D.; Colclough, A.; McDermott, C.; Bøtker, M.; Knudsen, L.; Harris, T.; Albaroudi, B.; Albaroudi, O.; Haddad, M.; Darke, R.; Berry, E.; Breslin, T.; Fitzpatrick, G.; Flanagan, L.; Olusanya, O.; Craver, D.; Omar, A.; Simpson, T.; Cherian, N.; Dore, M.; Prosen, G.; Kay, S.; Villén-Villegas, T.; Gargani, L.; Carley, S.; Woo, M.; Dupriez, F.; Hussain, A.; Via, G.; Connolly, J. A.; Peck, M.; Melniker, L.; Walden, A.; Attard Biancardi, M. A.; Żmijewska-Kaczor, O.; Lalande, E.; Geukens, P.; McLaughlin, R.; Olszynski, P.; Hoffmann, B.; Chin, E.; Muhr, C.; Kim, D. J.; Mercieca, A.; Shukla, D.; Hayward, S.; Smith, M.; Gaspari, R.; Smallwood, N.; Pes, P.; Tavazzi, G.; Corradi, F.; Lambert, M.; Morris, C.; Trauer, M.; Baker, K.; Bystrzycki, A.; Goudie, A.; Liu, R.; Rudd, L.; Dietrich, C. F.; Jenssen, C.; Sidhu, P. S. (Thieme Gruppe, 2022-10-13)

  OBJECTIVE:  To evaluate the evidence and produce a summary and recommendations for the most common heart and lung point-of-care ultrasound (PoCUS). METHODS:  We reviewed 10 clinical domains/questions related to common heart ...

• Multicenter evaluation of neoadjuvant and induction gemcitabine-carboplatin versus gemcitabine-cisplatin followed by radical cystectomy for muscle-invasive bladder cancer 

  Einerhand, S. M. H.; Black, A. J.; Zargar, H.; Fairey, A. S.; Dinney, C. P.; Mir, M. C.; Krabbe, L. M.; Cookson, M. S.; Jacobson, N. E.; Montgomery, J. S.; Vasdev, N.; Yu, E. Y.; Xylinas, E.; Kassouf, W.; Dall'Era, M. A.; Sridhar, S. S.; McGrath, J. S.; Aning, J.; Shariat, S. F.; Wright, J. L.; Thorpe, A. C.; Morgan, T. M.; Holzbeierlein, J. M.; Bivalacqua, T. J.; North, S.; Barocas, D. A.; Lotan, Y.; Grivas, P.; Garcia, J. A.; Stephenson, A. J.; Shah, J. B.; Daneshmand, S.; Zargar-Shoshtari, K.; Spiess, P. E.; van Rhijn, B. W. G.; Black, P. C.; Mertens, L. S. (Springer, 2022-11-01)

  PURPOSE: Cisplatin-based chemotherapy followed by radical cystectomy (RC) is recommended in patients with muscle-invasive bladder cancer (MIBC). However, up to 50% of patients are cisplatin ineligible. The aim of this study ...

• EFSUMB Clinical Practice Guidelines for Point-of-Care Ultrasound: Part One (Common Heart and Pulmonary Applications) LONG VERSION 

  Jarman, R. D.; McDermott, C.; Colclough, A.; Bøtker, M.; Knudsen, L.; Harris, T.; Albaroudi, B.; Albaroudi, O.; Haddad, M.; Darke, R.; Berry, E.; Breslin, T.; Fitzpatrick, G.; Flanagan, L.; Olusanya, O.; Craver, D.; Omar, A.; Simpson, T.; Cherian, N.; Dore, M.; Prosen, G.; Kay, S.; Villén-Villegas, T.; Gargani, L.; Carley, S.; Woo, M.; Dupriez, F.; Hussain, A.; Via, G.; Connolly, J. A.; Peck, M.; Melniker, L.; Walden, A.; Attard Biancardi, M. A.; Żmijewska-Kaczor, O.; Lalande, E.; Geukens, P.; McLaughlin, R.; Olszynski, P.; Hoffmann, B.; Chin, E.; Muhr, C.; Kim, D. J.; Mercieca, A.; Shukla, D.; Hayward, S.; Smith, M.; Gaspari, R.; Smallwood, N.; Pes, P.; Tavazzi, G.; Corradi, F.; Lambert, M.; Morris, C.; Trauer, M.; Baker, K.; Bystrzycki, A.; Goudie, A.; Liu, R.; Rudd, L.; Dietrich, C. F.; Jenssen, C.; Sidhu, P. S. (Thieme Gruppe, 2022-10-13)

  AIMS:  To evaluate the evidence and produce a summary and recommendations for the most common heart and lung applications of point-of-care ultrasound (PoCUS). METHODS:  We reviewed 10 clinical domains/questions related to ...

• Pause for thought: navigating the complex scientific domains of fatigue and of mindfulness-based practices in sarcoidosis and beyond 

  Saketkoo, L. A.; Patterson, K. C.; Russell, A. M. (Elsevier, 2022-11-22)

• Development of a treatment selection algorithm for SGLT2 and DPP-4 inhibitor therapies in people with type 2 diabetes: a retrospective cohort study 

  Dennis, J. M.; Young, K. G.; McGovern, A. P.; Mateen, B. A.; Vollmer, S. J.; Simpson, M. D.; Henley, W. E.; Holman, R. R.; Sattar, N.; Pearson, E. R.; Hattersley, A. T.; Jones, A. G.; Shields, B. M. (Elsevier, 2022-12-01)

  BACKGROUND: Current treatment guidelines do not provide recommendations to support the selection of treatment for most people with type 2 diabetes. We aimed to develop and validate an algorithm to allow selection of optimal ...

• Ginkgo biloba for tinnitus 

  Sereda, M.; Xia, J.; Scutt, P.; Hilton, M. P.; El Refaie, A.; Hoare, D. J. (Wiley, 2022-11-16)

  BACKGROUND: Tinnitus is a symptom defined as the perception of sound in the absence of an external source. In England alone there are an estimated ¾ million general practice consultations every year where the primary ...

• Rituximab versus intravenous cyclophosphamide in patients with connective tissue disease-associated interstitial lung disease in the UK (RECITAL): a double-blind, double-dummy, randomised, controlled, phase 2b trial 

  Maher, T. M.; Tudor, V. A.; Saunders, P.; Gibbons, M. A.; Fletcher, S. V.; Denton, C. P.; Hoyles, R. K.; Parfrey, H.; Renzoni, E. A.; Kokosi, M.; Wells, A. U.; Ashby, D.; Szigeti, M.; Molyneaux, P. L. (Elsevier, 2022-11-11)

  BACKGROUND: Rituximab is often used as rescue therapy in interstitial lung disease (ILD) associated with connective tissue disease (CTD), but has not been studied in clinical trials. This study aimed to assess whether ...

• Detailed statistical analysis plan for a randomised controlled trial of the effects of a modified muscle sparing posterior technique (SPAIRE) in hip hemiarthroplasty for displaced intracapsular fractures on post-operative function compared to a standard lateral approach: HemiSPAIRE 

  Ball, S.; McAndrew, A.; Aylward, A.; Cockcroft, E.; Gordon, E.; Kerridge, A.; Morgan-Trimmer, S.; Powell, R.; Price, A.; Rhodes, S.; Timperley, A. J.; van Horik, J.; Wickins, R.; Charity, J. (BioMed Central, 2022-11-05)

  BACKGROUND: The HemiSPAIRE trial is being conducted to determine whether a modified muscle sparing technique (SPAIRE-Save Piriformis and Internus, Repairing Externus") in hip hemiarthroplasty brings clinical benefits ...

• Intravenous ferric derisomaltose in patients with heart failure and iron deficiency in the UK (IRONMAN): an investigator-initiated, prospective, randomised, open-label, blinded-endpoint trial 

  Kalra, P. R.; Cleland, J. G. F.; Petrie, M. C.; Thomson, E. A.; Kalra, P. A.; Squire, I. B.; Ahmed, F. Z.; Al-Mohammad, A.; Cowburn, P. J.; Foley, P. W. X.; Graham, F. J.; Japp, A. G.; Lane, R. E.; Lang, N. N.; Ludman, A. J.; Macdougall, I. C.; Pellicori, P.; Ray, R.; Robertson, M.; Seed, A.; Ford, I. (Elsevier, 2022-11-04)

  BACKGROUND: For patients with heart failure, reduced left ventricular ejection fraction and iron deficiency, intravenous ferric carboxymaltose administration improves quality of life and exercise capacity in the short-term ...

• An internal pilot study of a novel rectal mucocellular sampling device to allow next-generation sequencing for colorectal disease 

  Humphrey, H. N.; Diodato, A.; Isner, J. C.; Walker, E.; Lacy-Colson, J.; Nedjai, B.; Daniels, I. R. (Springer, 2022-09-27)

  BACKGROUND: The ORI-EGI-02 study was designed to test the hypothesis that rectal mucus collected using a novel rectal sampling device (OriCol™), contains sufficient human deoxyribonucleic acid (DNA) of the required quality ...

• Hyperinsulinaemic hypoglycaemia diagnosed in childhood can be monogenic 

  Hopkins, J. J.; Childs, A. J.; Houghton, J. A.; Hewat, T. I.; Atapattu, N.; Johnson, M. B.; Patel, K. A.; Laver, T. W.; Flanagan, S. E. (Endocrine Society, 2022-10-14)

  BACKGROUND: Congenital hyperinsulinism (HI) is characterised by inappropriate insulin secretion despite low blood glucose. Persistent HI is often monogenic, with the majority of cases diagnosed in infancy. Less is known ...

• Conservative management of patients with endometrial intraepithelial neoplasia (EIN): Factors that could affect response and pregnancy rates 

  Iavazzo, C.; Gkegkes, I. D. (TUBITAK, 2022-06-01)

• Laparoscopic cholecystectomy in children: A systematic review and meta-analysis 

  Mattson, A.; Sinha, A.; Njere, I.; Borkar, N.; Sinha, C. K. (Elsevier, 2022-10-12)

  BACKGROUND: Laparoscopic cholecystectomy (LC) has become the procedure of choice for the removal of gallbladder within the paediatric population. The aim of this study was to perform a systematic review and meta-analysis ...

• Real-world experience of intravenous ferric derisomaltose evaluated through safety and efficacy reporting in the UK 

  Sinclair, R. C. F.; Nadaraja, S.; Kennedy, N. A.; Wakatsuki, M.; Bhandari, S. (Nature, 2022-11-07)

  Ferric derisomaltose (FDI; Monofer) is used in clinical practice to treat iron deficiency, but the safety and efficacy of FDI has not been robustly evaluated in a large real-world study. This retrospective, multicentre, ...

• Development of a competency framework for the Assistant Wellbeing Practitioner (Renal) role 

  Farrand, P.; Hamilton, A.; Strickland, S. (Wiley, 2022-12-03)

  BACKGROUND: Many people with kidney disease experience comorbid mental health difficulties that result in worse physical health outcomes alongside greater personal, treatment and societal costs. PROBLEM: Workforce expansion ...

• Neurodevelopmental and Epilepsy Phenotypes in Individuals With Missense Variants in the Voltage Sensing and Pore Domain of KCNH5 

  Happ, H. C.; Sadleir, L. G.; Zemel, M.; de Valles-Ibáñez, G.; Hildebrand, M. S.; McConkie-Rosell, A.; McDonald, M.; May, H.; Sands, T.; Aggarwal, V.; Elder, C.; Feyma, T.; Bayat, A.; Møller, R. S.; Fenger, C. D.; Klint Nielsen, J. E.; Datta, A. N.; Gorman, K. M.; King, M. D.; Linhares, N.; Burton, B. K.; Paras, A.; Ellard, S.; Rankin, J.; Shukla, A.; Majethia, P.; Olson, R. J.; Muthusamy, K.; Schimmenti, L. A.; Starnes, K.; Sedlackova, L.; Sterbova, K.; Vlckova, M.; Lassuthova, P.; Jahodova, A.; Porter, B. E.; Couque, N.; Colin, E.; Prouteau, C.; Collet, C.; Smol, T.; Caumes, R.; Vansenne, F.; Bisulli, F.; Licchetta, L.; Person, R.; Torti, E.; McWalter, K.; Webster, R.; Gerard, E. E.; Lesca, G.; Szepetowski, P.; Scheffer, I. E.; Mefford, H. C.; Carvill, G. L. (Wolters Kluwer, 2022-10-28)

  OBJECTIVE: KCNH5 encodes the voltage-gated potassium channel EAG2/Kv10.2. We aimed to delineate the neurodevelopmental and epilepsy phenotypic spectrum associated with de novo KCNH5 variants. METHODS: We screened 893 ...

• A systematic review aggregated data and individual participant data meta-analysis of percutaneous endovascular arteriovenous fistula 

  Bontinis, A.; Bontinis, V.; Koutsoumpelis, A.; Wilmink, T.; Giannopoulos, A.; Rafailidis, V.; Chorti, A.; Ktenidis, K. (Elsevier, 2022-10-31)

  OBJECTIVE: To assess the short-term and mid-term safety and efficacy of percutaneous endovascular arteriovenous fistula (pAVF) creation. METHODS: A systematic search was implemented corresponding to the PRISMA 2020 and the ...

• Surgeon and physiotherapist approaches to operative or non-operative management of people with recurrent patellar dislocation: A case-based UK survey 

  Irving, L.; Smith, T. O.; Mandalia, V. I.; Pratt, A.; Dowen, D. (Wiley, 2022-11-18)

  BACKGROUND: Physiotherapists are often key decision-makers on when to refer patients with recurrent patellar dislocation for surgical opinion. Limited guidance exists to aid this decision. Differences in orthopaedic surgeons' ...

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