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dc.contributor.authorWild, J. M.
dc.contributor.authorPorter, J. C.
dc.contributor.authorMolyneaux, P. L.
dc.contributor.authorGeorge, P. M.
dc.contributor.authorStewart, I.
dc.contributor.authorAllen, R. J.
dc.contributor.authorAul, R.
dc.contributor.authorBaillie, J. K.
dc.contributor.authorBarratt, S. L.
dc.contributor.authorBeirne, P.
dc.contributor.authorBianchi, S. M.
dc.contributor.authorBlaikley, J. F.
dc.contributor.authorBrooke, J.
dc.contributor.authorChaudhuri, N.
dc.contributor.authorCollier, G.
dc.contributor.authorDenneny, E. K.
dc.contributor.authorDocherty, A.
dc.contributor.authorFabbri, L.
dc.contributor.authorGibbons, M. A.
dc.contributor.authorGleeson, F. V.
dc.contributor.authorGooptu, B.
dc.contributor.authorHall, I. P.
dc.contributor.authorHanley, N. A.
dc.contributor.authorHeightman, M.
dc.contributor.authorHillman, T. E.
dc.contributor.authorJohnson, S. R.
dc.contributor.authorJones, M. G.
dc.contributor.authorKhan, F.
dc.contributor.authorLawson, R.
dc.contributor.authorMehta, P.
dc.contributor.authorMitchell, J. A.
dc.contributor.authorPlaté, M.
dc.contributor.authorPoinasamy, K.
dc.contributor.authorQuint, J. K.
dc.contributor.authorRivera-Ortega, P.
dc.contributor.authorSemple, M.
dc.contributor.authorSimpson, A. J.
dc.contributor.authorSmith, D.
dc.contributor.authorSpears, M.
dc.contributor.authorSpencer, L. G.
dc.contributor.authorStanel, S. C.
dc.contributor.authorThickett, D. R.
dc.contributor.authorThompson, A. A. R.
dc.contributor.authorWalsh, S. L.
dc.contributor.authorWeatherley, N. D.
dc.contributor.authorWeeks, M. E.
dc.contributor.authorWootton, D. G.
dc.contributor.authorBrightling, C. E.
dc.contributor.authorChambers, R. C.
dc.contributor.authorHo, L. P.
dc.contributor.authorJacob, J.
dc.contributor.authorPiper Hanley, K.
dc.contributor.authorWain, L. V.
dc.contributor.authorJenkins, R. G.
dc.date.accessioned2021-12-15T14:25:48Z
dc.date.available2021-12-15T14:25:48Z
dc.date.issued2021-09-01
dc.identifier.citationBMJ Open Respir Res. 2021 Sep;8(1):e001049. doi: 10.1136/bmjresp-2021-001049.
dc.identifier.pmid34556492
dc.identifier.doi10.1136/bmjresp-2021-001049
dc.identifier.urihttps://rde.dspace-express.com/handle/11287/622328
dc.description.abstractINTRODUCTION: The COVID-19 pandemic has led to over 100 million cases worldwide. The UK has had over 4 million cases, 400 000 hospital admissions and 100 000 deaths. Many patients with COVID-19 suffer long-term symptoms, predominantly breathlessness and fatigue whether hospitalised or not. Early data suggest potentially severe long-term consequence of COVID-19 is development of long COVID-19-related interstitial lung disease (LC-ILD). METHODS AND ANALYSIS: The UK Interstitial Lung Disease Consortium (UKILD) will undertake longitudinal observational studies of patients with suspected ILD following COVID-19. The primary objective is to determine ILD prevalence at 12 months following infection and whether clinically severe infection correlates with severity of ILD. Secondary objectives will determine the clinical, genetic, epigenetic and biochemical factors that determine the trajectory of recovery or progression of ILD. Data will be obtained through linkage to the Post-Hospitalisation COVID platform study and community studies. Additional substudies will conduct deep phenotyping. The Xenon MRI investigation of Alveolar dysfunction Substudy will conduct longitudinal xenon alveolar gas transfer and proton perfusion MRI. The POST COVID-19 interstitial lung DiseasE substudy will conduct clinically indicated bronchoalveolar lavage with matched whole blood sampling. Assessments include exploratory single cell RNA and lung microbiomics analysis, gene expression and epigenetic assessment. ETHICS AND DISSEMINATION: All contributing studies have been granted appropriate ethical approvals. Results from this study will be disseminated through peer-reviewed journals. CONCLUSION: This study will ensure the extent and consequences of LC-ILD are established and enable strategies to mitigate progression of LC-ILD.
dc.language.isoeng
dc.publisherBMJ
dc.rights© Author(s) (or their employer(s)) 2021. Re-use permitted under CC BY. Published by BMJ.
dc.rights.urihttp://creativecommons.org/publicdomain/zero/1.0/
dc.subjectCOVID-19/*complications
dc.subjectHumans
dc.subjectLongitudinal Studies
dc.subject*Lung Diseases, Interstitial/epidemiology
dc.subjectObservational Studies as Topic
dc.subjectPandemics
dc.subjectProspective Studies
dc.subjectUnited Kingdom/epidemiology
dc.subject*covid-19
dc.subject*bronchoscopy
dc.subject*interstitial fibrosis
dc.titleUnderstanding the burden of interstitial lung disease post-COVID-19: the UK Interstitial Lung Disease-Long COVID Study (UKILD-Long COVID)
dc.typeJournal Article
dc.identifier.journalBMJ open respiratory research
dc.identifier.pmcidPMC8461362
dc.description.noteThe article is available via Open Access. Click on the 'Additional link' above to access the full-text.
dc.type.versionppublish
dc.description.admin-notePublished version, accepted version, submitted version
dc.date.epub2021-09-25
dc.citation.volume8
dc.citation.issue1


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© Author(s) (or their employer(s)) 2021. Re-use permitted under CC BY. Published by BMJ.
Except where otherwise noted, this item's license is described as © Author(s) (or their employer(s)) 2021. Re-use permitted under CC BY. Published by BMJ.