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dc.contributor.authorBallard, Clive
dc.date.accessioned2021-06-08T10:36:00Z
dc.date.available2021-06-08T10:36:00Z
dc.date.issued2020-12
dc.identifier.citationKillick R et al. Transcription-based drug repurposing for COVID-19. Virus Res. 2020 Dec;290:198176. doi: 10.1016/j.virusres.2020.198176. Epub 2020 Sep 25.en_US
dc.identifier.pmid32987033
dc.identifier.doi10.1016/j.virusres.2020.198176
dc.identifier.urihttps://rde.dspace-express.com/handle/11287/621748
dc.description.abstractWe have utilised the transcriptional response of lung epithelial cells following infection by the original Severe Acute Respiratory Syndrome coronavirus (SARS) to identify repurposable drugs for COVID-19. Drugs best able to recapitulate the infection profile are highly enriched for antiviral activity. Nine of these have been tested against SARS-2 and found to potently antagonise SARS-2 infection/replication, with a number now being considered for clinical trials. It is hoped that this approach may serve to broaden the spectrum of approved drugs that should be further assessed as potential anti-COVID-19 agents and may help elucidate how this seemingly disparate collection of drugs are able to inhibit SARS-2 infection/replication.en_US
dc.language.isoenen_US
dc.publisherElsevier Scienceen_US
dc.relation.urlhttps://linkinghub.elsevier.com/retrieve/pii/S0168-1702(20)31083-2en_US
dc.rightsCopyright © 2020. Published by Elsevier B.V.en_US
dc.subjectCOVID-19en_US
dc.subjectGene expressionen_US
dc.subjectRepurposingen_US
dc.subjectWessex Classification Subject Headings::Communicable diseasesen_US
dc.titleTranscription-based drug repurposing for COVID-19en_US
dc.typeJournal Articleen_US
dc.identifier.journalVirus Researchen_US
dc.identifier.pmcidPMC7518800
dc.type.versionPublisheden_US
dc.description.admin-notepublished version, accepted version (12 month embargo)en_US


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