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dc.contributor.authorBallard, Clive
dc.identifier.citationBorda MG et al. Neuropsychiatric Symptoms and Functional Decline in Alzheimer's Disease and Lewy Body Dementia. J Am Geriatr Soc. 2020 Oct;68(10):2257-2263. doi: 10.1111/jgs.16709. Epub 2020 Aug 1.en_US
dc.description.abstractBackground/objectives: Functional status is one of the most important markers of well-being in older adults, but the drivers of functional decline in dementia are not well known. The aim of our work was to study the association of neuropsychiatric symptoms (NPSs) with functional decline over 5 years in newly diagnosed people with Alzheimer´s disease (AD) and Lewy body dementia (LBD). Design: Secondary analysis of the Dementia Study of Western Norway longitudinal cohort study. Setting: Multicenter study conducted in memory clinics in western Norway. Participants: We included a total of 196 patients newly diagnosed with AD (n = 111) and LBD (n = 85), followed up annually for 5 years. Main outcomes and measures: The outcome was the rapid disability rating scale (items 1-13). Linear mixed-effects models were used for analysis with the total score of the Norwegian Neuropsychiatric Inventory (NPI) as a predictor measured either at baseline or longitudinally, adjusted for potential confounders, including cognition. Effect modification was checked by introducing interactions with NPI score and stratifying by diagnosis. Results: The total NPI score longitudinal course was associated with functional decline in both AD and LBD. At baseline, the total NPI score predicted functional decline in AD. Conclusion: NPSs were associated with the rate of functional decline in people with AD and LBD, independent of cognitive impairment. These results highlight the relevance of early detection and intervention of NPSs, which may also reduce functional decline. J Am Geriatr Soc 68:2257-2263, 2020.en_US
dc.rights© 2020 The American Geriatrics Society.en_US
dc.subjectAlzheimerʼs diseaseen_US
dc.subjectLewy body dementiaen_US
dc.subjectfunctional statusen_US
dc.subjectneuropsychiatric symptomsen_US
dc.titleNeuropsychiatric Symptoms and Functional Decline in Alzheimer's Disease and Lewy Body Dementiaen_US
dc.typeJournal Articleen_US
dc.identifier.journalJournal of the American Geriatrics Societyen_US
dc.description.noteThis article is available to RD&E staff via NHS OpenAthens. Click on the Publisher URL, and log in with NHS OpenAthens if prompted.en_US
dc.description.fundingHelse Vest. Grant Number: n/aen_US
dc.description.admin-notepublished version, accepted version (12 month embargo), submitted versionen_US

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