Browsing 2021 RD&E publications by Title
Now showing items 1-20 of 344
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100 years of insulin: celebrating the past, present and future of diabetes therapy
(Nature, 2021-07-15)The year 2021 marks the centennial of Banting and Best's landmark description of the discovery of insulin. This discovery and insulin's rapid clinical deployment effectively transformed type 1 diabetes from a fatal diagnosis ... -
12 Being Non-Frail and Free From Cardiovascular Disease Reduces COVID-19 Risk in 269,164 Older UK Biobank Participants
(Oxford University Press, 2021-03-01)Older adults are at increased risk of COVID-19, resulting in public health shielding measures for all adults over 70 in the UK. Frailty has been proposed for risk stratification in COVID-19 with limited evidence. Cardiovascular ... -
14-month old boy with abrupt-onset petechiae and bruising
(BMJ, 2021-02-01)A healthy 14-month-old boy presented with a 2-day history of widespread petechiae and bruising. Parents were originally from East Asia, and the boy was born in the UK. He was clinically well with no organomegaly. He had a ... -
52 I’m on the Floor and Can’t Get up and it’s Really Annoying: A Qualitative Investigation of Patient and Staff Perceptions of Options for Getting up From the Floor Following A Fall
(Oxford University Press, 2021-03-01)Falls are the most common reason for ambulance call-outs resulting in non-conveyance. Even in the absence of injury, only half of those who have fallen can get themselves up off the floor. Many remain there for over an ... -
A dosimetric study to improve the quality of nodal radiotherapy in breast cancer
(British Institute of Radiology, 2021-08-13)OBJECTIVES: Field-based planning for regional nodal breast radiotherapy (RT) used to be standard practice. This study evaluated a field-based posterior axillary boost (PAB) and two forward-planned intensity-modulated RT ... -
A genome-wide association study identifies 5 loci associated with frozen shoulder and implicates diabetes as a causal risk factor
(PLoS One, 2021-06-10)Frozen shoulder is a painful condition that often requires surgery and affects up to 5% of individuals aged 40–60 years. Little is known about the causes of the condition, but diabetes is a strong risk factor. To begin to ... -
A hemizygous mutation in the FOXP3 gene (IPEX syndrome) resulting in recurrent X-linked fetal hydrops: a case report
(Springer, 2021-02-26)Fetal hydrops is excessive extravasation of fluid into the third space in a fetus, which could be due to a wide differential of underlying pathology. IPEX (immune dysregulation, polyendocrinopathy, enteropathy, X-linked) ... -
A meta-analysis of epigenome-wide association studies in Alzheimer's disease highlights novel differentially methylated loci across cortex
(Nature, 2021-06-10)Epigenome-wide association studies of Alzheimer's disease have highlighted neuropathology-associated DNA methylation differences, although existing studies have been limited in sample size and utilized different brain ... -
A multicenter randomized controlled trial indicates that paclitaxel-coated balloons provide no benefit for arteriovenous fistulas
(Elsevier, 2021-03-27)The role of paclitaxel-coated balloons has been established in the coronary and peripheral arterial circulations with recent interest in the use of paclitaxel-coated balloons to improve patency rates following angioplasty ... -
A Multicentre Retrospective Analysis of Toxicity in 6-weekly Versus 3-weekly Pembrolizumab
(Elsevier, 2021-05-01)Pembrolizumab is an anti-programmed cell death protein 1 immune checkpoint inhibitor with a dosing schedule of 200 mg 3 weekly (q3w). Dose of 400 mg 6 weekly (q6w) was approved based on simulation of dose/exposure relationships ... -
A national retrospective study of the association between serious operational problems and COVID-19 specific intensive care mortality risk
(PLoS One, 2021-07-29)OBJECTIVES: To describe the relationship between reported serious operational problems (SOPs), and mortality for patients with COVID-19 admitted to intensive care units (ICUs). DESIGN: English national retrospective cohort ... -
A New Era in Epicardial Access for the Ablation of Ventricular Arrhythmias: The Epi-Co(2) Registry
(JACC, 2021-01-01)OBJECTIVES: This multicenter registry aimed to assess the reproducibility and safety of intentional coronary vein exit and carbon dioxide insufflation to facilitate subxiphoid epicardial access in the setting of ventricular ... -
A Practical Guide to Genetic Testing in Endocrinology
(Wiley, 2021-09-16)Rapid advances in sequencing technology have led to significant improvements in genomic analysis, resulting in increased understanding of the molecular basis of many endocrine conditions. Genomic testing for rare disease ... -
A Prospective Cohort Study Comparing Functional Outcomes of Primary and Revision Ankle Replacements.
(SAGE, 2021-06-11)BACKGROUND: The number of ankle and revision ankle replacements performed is increasing. There is limited research into functional outcomes, especially in revision ankle replacements. The primary aim of this cohort study ... -
A randomised, double-blind study investigating the relationship between early childhood trauma and the rewarding effects of morphine.
(Wiley, 2021-06-21)Experiences of childhood trauma (abuse and neglect) are disproportionately higher in those with opioid use disorder (OUD). Childhood trauma may affect the reinforcing and rewarding properties of opioid drugs and responses ... -
A Rare Finding A Left Atrial Cavernous Haemangioma
(EMJ, 2021-07-01) -
A Review of Aflibercept Treatment for Macular Disease
(Springer, 2021-06-13)Aflibercept is a fully human recombinant fusion protein that includes the second domain of human VEGF receptor 1 and the third domain of human VEGF receptor 2. Despite the important role played by VEGF in maintaining the ... -
A Revised Hilbert-Huang Transformation to Track Non-Stationary Association of Electroencephalography Signals
(Institute of Electrical and Electronics Engineers, 2021-04-28)The time-varying cross-spectrum method has been used to effectively study transient and dynamic brain functional connectivity between non-stationary electroencephalography (EEG) signals. Wavelet-based cross-spectrum is one ... -
A second report of recessive type COL4A1-related disorder: a novel homozygous missense variant.
(Wolters Kluwer, 2021-04-01) -
A semi-Markov model comparing the lifetime cost-effectiveness of mesh prophylaxis to prevent parastomal hernia in patients undergoing end colostomy creation for rectal cancer
(Wiley, 2021-07-31)AIM: Parastomal hernia (PSH) is a common problem following colostomy. Using prophylactic mesh during end colostomy creation may reduce PSH incidence, but concerns exist regarding the optimal type of mesh, potential long-term ...