Browsing 2021 RD&E publications by Title
Now showing items 1-12 of 12
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Genome-Wide Association Analysis of Pancreatic Beta-Cell Glucose Sensitivity
(Silverchair Information Systems, 2021-01-01)Context: Pancreatic beta-cell glucose sensitivity is the slope of the plasma glucose-insulin secretion relationship and is a key predictor of deteriorating glucose tolerance and development of type 2 diabetes. However, ... -
Glucagon-like peptide-1 receptor agonists as neuroprotective agents for ischemic stroke: a systematic scoping review
(Atypon, 2021-01)Stroke mortality and morbidity is expected to rise. Despite considerable recent advances within acute ischemic stroke treatment, scope remains for development of widely applicable neuroprotective agents. Glucagon-like ... -
Increased Induction Infliximab Clearance Predicts Early Antidrug Antibody Detection
(Wiley, 2021-02)Treatment of patients with biologics such as infliximab may trigger development of antidrug antibodies, which are associated with faster drug clearance, reduced treatment efficacy, and increased risk of infusion-related ... -
Pathogenic germline variants in patients with features of hereditary renal cell carcinoma: Evidence for further locus heterogeneity
(Wiley, 2021-01)Inherited renal cell carcinoma (RCC) is associated with multiple familial cancer syndromes but most individuals with features of non-syndromic inherited RCC do not harbor variants in the most commonly tested renal cancer ... -
Potentially inappropriate prescribing in dementia, multi-morbidity and incidence of adverse health outcomes
(Oxford University Press, 2021-02-26)Importance: treatment of dementia in individuals with comorbidities is complex, leading to potentially inappropriate prescribing (PIP). The impact of PIP in this population is unknown. Objective: to estimate the rate ... -
Real-world adherence, persistence, and in-class switching during use of dipeptidyl peptidase-4 inhibitors: a systematic review and meta-analysis involving 594,138 patients with type 2 diabetes
(Springer, 2021-01)Aims: Medication adherence and persistence are important determinants of treatment success in type 2 diabetes mellitus (T2DM). This systematic review and meta-analysis evaluated the real-world adherence, persistence, and ... -
Republished: Immune checkpoint inhibitor induced large vessel vasculitis
(HighWire, 2021-02) -
UK Royal Society of Medicine Venous Forum VTE Advice 2020
(Atypon, 2021-03)