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dc.contributor.authorFussey, Jonathan
dc.identifier.citationBorsetto D et al. HCV infection and the risk of head and neck cancer: A meta-analysis. Oral Oncol. 2020 Jun 26;109:104869. doi: 10.1016/j.oraloncology.2020.104869. Epub ahead of print.en_US
dc.description.abstractRecent evidence has consistently suggested a role for HCV in the etiology of head and neck squamous cell carcinoma (HNSCC), but the conclusions of these studies have often been limited by small sample size. Therefore, a meta-analysis was performed to summarize present evidence on the association between HCV infection and HNSCC. After screening citations from literature search, eight observational studies investigating the association between HCV and cancer(s) of either oral cavity, oropharynx, hypopharynx or larynx were included. For each cancer site, risk ratios from individual studies were displayed in forest plots; pooled risk ratios (RR) and corresponding confidence intervals (CI) were calculated. A significant association was found between HCV infection and cancers of the oral cavity (RR = 2.13; 95%: 1.61-2.83), oropharynx (RR = 1.81; 95% CI: 1.21-2.72), and larynx (RR = 2.57; 95% CI: 1.11-5.94). A similar picture emerged for hypopharyngeal cancer, though this result did not fully reach statistical significance because of the small number of available studies (RR = 2.15; 95% CI: 0.73-6.31). These findings remained similar after exclusion of patients with HIV co-infection. Our results highlighted the importance of surveillance of the upper aerodigestive tract in patients with known chronic HCV infections in order to enable HNSCC early diagnosis. In addition, they could be a reminder of the possibility of undiagnosed HCV infection to the clinicians treating HNSCC.en_US
dc.publisherElsevier Scienceen_US
dc.rightsCopyright © 2020 Elsevier Ltd. All rights reserved.en_US
dc.subjectCancer risken_US
dc.subjectHead and neck canceren_US
dc.subjectHepatitis C virusen_US
dc.subjectLaryngeal canceren_US
dc.subjectOral canceren_US
dc.subjectOropharyngeal canceren_US
dc.subjectWessex Classification Subject Headings::Oncology. Pathology.en_US
dc.subjectWessex Classification Subject Headings::Ear, Nose & Throaten_US
dc.titleHCV infection and the risk of head and neck cancer: A meta-analysisen_US
dc.typeJournal Articleen_US
dc.identifier.journalOral Oncologyen_US
dc.type.versionIn press (epub ahead of print)en_US
dc.description.admin-notepublished version, accepted version (12 month embargo)en_US

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