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dc.contributor.authorAuckland, Cressida
dc.contributor.authorPoznalska, Gosia
dc.contributor.authorRoberts, Stella
dc.date.accessioned2020-11-30T12:02:18Z
dc.date.available2020-11-30T12:02:18Z
dc.date.issued2020-09
dc.identifier.citationBrown CS et al. Snapshot PCR surveillance for SARS-CoV-2 in hospital staff in England. J Infect. 2020 Sep;81(3):427-434. doi: 10.1016/j.jinf.2020.06.069. Epub 2020 Jun 30.en_US
dc.identifier.pmid32615198
dc.identifier.doi10.1016/j.jinf.2020.06.069
dc.identifier.urihttps://rde.dspace-express.com/handle/11287/621576
dc.description.abstractBackground: Significant nosocomial transmission of SARS-CoV-2 has been demonstrated. Understanding the prevalence of SARS-CoV-2 carriage amongst HCWs at work is necessary to inform the development of HCW screening programmes to control nosocomial spread. Methods: Cross-sectional 'snapshot' survey from April-May 2020; HCWs recruited from six UK hospitals. Participants self-completed a health questionnaire and underwent a combined viral nose and throat swab, tested by Polymerase Chain Reaction (PCR) for SARS-CoV-2 with viral culture on majority of positive samples. Findings: Point prevalence of SARS-CoV-2 carriage across the sites was 2.0% (23/1152 participants), median cycle threshold value 35.70 (IQR:32.42-37.57). 17 were previously symptomatic, two currently symptomatic (isolated anosmia and sore throat); the remainder declared no prior or current symptoms. Symptoms in the past month were associated with threefold increased odds of testing positive (aOR 3.46, 95%CI 1.38-8.67; p = 0.008). SARS-CoV-2 virus was isolated from only one (5%) of nineteen cultured samples. A large proportion (39%) of participants reported symptoms in the past month. Interpretation: The point-prevalence is similar to previous estimates for HCWs in April 2020, though a magnitude higher than in the general population. Based upon interpretation of symptom history and testing results including viral culture, the majority of those testing positive were unlikely to be infectious at time of sampling. Development of screening programmes must balance the potential to identify additional cases based upon likely prevalence, expanding the symptoms list to encourage HCW testing, with resource implications and risks of excluding those unlikely to be infectious with positive tests.en_US
dc.language.isoenen_US
dc.publisherElsevier Scienceen_US
dc.relation.urlhttps://linkinghub.elsevier.com/retrieve/pii/S0163-4453(20)30450-3en_US
dc.rightsCrown Copyright © 2020 Published by Elsevier Ltd on behalf of The British Infection Association. All rights reserved.en_US
dc.rightsCC0 1.0 Universal*
dc.rights.urihttp://creativecommons.org/publicdomain/zero/1.0/*
dc.subjectPCR surveillanceen_US
dc.subjectSARS-CoV-2en_US
dc.subjecthospital staffen_US
dc.subjectEnglanden_US
dc.titleSnapshot PCR surveillance for SARS-CoV-2 in hospital staff in Englanden_US
dc.typeJournal Articleen_US
dc.identifier.journalThe Journal of Infectionen_US
dc.identifier.pmcidPMC7324345
dc.description.noteThis article is freely available via Open Access. Click on the Publisher URL to access it via the publisher's site.en_US
dc.description.fundingPublic Health Englanden_US
dc.type.versionPublisheden_US
dc.description.admin-notepublished version, accepted version (12 month embargo)en_US


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Crown Copyright © 2020 Published by Elsevier Ltd on behalf of The British Infection Association. All
rights reserved.
Except where otherwise noted, this item's license is described as Crown Copyright © 2020 Published by Elsevier Ltd on behalf of The British Infection Association. All rights reserved.