• Login
    View Item 
    •   RD&E Research Repository Home
    • All RD&E publications by year
    • 2019 RD&E publications
    • View Item
    •   RD&E Research Repository Home
    • All RD&E publications by year
    • 2019 RD&E publications
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Patterns of postmeal insulin secretion in individuals with sulfonylurea- treated KCNJ11 neonatal diabetes show predominance of non- KATP- channel pathways

    Thumbnail
    View/Open
    Open Access article (455.4Kb)
    URI
    https://rde.dspace-express.com/handle/11287/621290
    Author
    Bowman, Pamela
    McDonald, Timothy J.
    Knight, Bridget A.
    Flanagan, Sarah
    Leveridge, Maria
    Spaull, Steve R
    Shields, Beverley M
    Hammersley, Suzanne
    Shepherd, Maggie
    Andrews, Rob
    Patel, Kashyap A
    Hattersley, Andrew T.
    Date
    2019-12
    Journal
    BMJ Open Diabetes Research & Care
    Type
    Journal Article
    Publisher
    BMJ
    DOI
    10.1136/bmjdrc-2019-000721
    Rights
    This is an open access article distributed in accordance with the Creative Commons Attribution 4.0 Unported (CC BY 4.0) license, which permits others to copy, redistribute, remix, transform and build upon this work for any purpose, provided the original work is properly cited, a link to the licence is given, and indication of whether changes were made. See: https://creativecommons.org/licenses/by/4.0/.
    Metadata
    Show full item record
    Abstract
    Insulin secretion in sulfonylurea-treated KCNJ11 permanent neonatal diabetes mellitus (PNDM) is thought to be mediated predominantly through amplifying non-KATP-channel pathways such as incretins. Affected individuals report symptoms of postprandial hypoglycemia after eating protein/fat-rich foods. We aimed to assess the physiological response to carbohydrate and protein/fat in people with sulfonylurea-treated KCNJ11 PNDM.
    Citation
    Bowman P [et al]. Patterns of postmeal insulin secretion in individuals with sulfonylurea- treated KCNJ11 neonatal diabetes show predominance of non- KATP- channel pathways. BMJ Open Diabetes Research & Care. 2019 Dec 18;7(1):e000721
    Publisher URL
    https://drc.bmj.com/cgi/pmidlookup?view=long&pmid=31908791
    Note
    This article is freely available via Open Access. Click on the Publisher URL to access the full-text via the publisher's site.
    Collections
    • 2019 RD&E publications
    • Diabetes/Endocrine Services
    • Exeter Clinical Laboratory International (Blood Sciences, Genetics, Cellular Pathology & Microbiology)
    • Molecular Genetics
    • Nursing & Allied Health professionals

    Browse

    All of RD&E Research RepositoryCommunities & CollectionsBy Issue DateAuthorsTitlesSubjectsThis CollectionBy Issue DateAuthorsTitlesSubjects

    My Account

    LoginRegister

    DSpace software copyright © 2002-2021  DuraSpace
    Contact Us | Send Feedback
    DSpace Express is a service operated by 
    Atmire NV