Patterns of postmeal insulin secretion in individuals with sulfonylurea- treated KCNJ11 neonatal diabetes show predominance of non- KATP- channel pathways

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https://rde.dspace-express.com/handle/11287/621290
Author
Bowman, Pamela
McDonald, Timothy J.
Knight, Bridget A
Flanagan, Sarah
Leveridge, Maria
Spaull, Steve R
Shields, Beverley M
Hammersley, Suzanne
Shepherd, Maggie
Andrews, Rob
Patel, Kashyap A
Hattersley, Andrew T.
Date
2019-12
Journal
BMJ Open Diabetes Research & Care
Type
Journal Article
Publisher
BMJ
DOI
10.1136/bmjdrc-2019-000721
Rights
This is an open access article distributed in accordance with the Creative Commons Attribution 4.0 Unported (CC BY 4.0) license, which permits others to copy, redistribute, remix, transform and build upon this work for any purpose, provided the original work is properly cited, a link to the licence is given, and indication of whether changes were made. See: https://creativecommons.org/licenses/by/4.0/.
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Abstract
Insulin secretion in sulfonylurea-treated KCNJ11 permanent neonatal diabetes mellitus (PNDM) is thought to be mediated predominantly through amplifying non-KATP-channel pathways such as incretins. Affected individuals report symptoms of postprandial hypoglycemia after eating protein/fat-rich foods. We aimed to assess the physiological response to carbohydrate and protein/fat in people with sulfonylurea-treated KCNJ11 PNDM.
Citation
Bowman P [et al]. Patterns of postmeal insulin secretion in individuals with sulfonylurea- treated KCNJ11 neonatal diabetes show predominance of non- KATP- channel pathways. BMJ Open Diabetes Research & Care. 2019 Dec 18;7(1):e000721
Publisher URL
https://drc.bmj.com/cgi/pmidlookup?view=long&pmid=31908791
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This article is freely available via Open Access. Click on the Publisher URL to access the full-text via the publisher's site.
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