NMDA receptor antibody encephalitis presenting as Transient Epileptic Amnesia

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Authors
Zeman, Adam
Journal
Journal of Neuroimmunology
Type
Journal Article
Publisher
Elsevier
Rights
This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
Transient Epileptic Amnesia (TEA) is a subtype of temporal lobe epilepsy, typically presenting in a person's early 60s, and of unknown aetiology. Encephalitis caused by antibodies to NMDA receptors (NMDARE) has not previously been documented in TEA. We describe a 47-year-old male who satisfied criteria for TEA, but given his atypical symptoms, was also screened for autoimmune epilepsy. High levels of serum NMDAR antibodies were found, suggesting NMDARE. Immunosuppressive treatment gradually eliminated the NMDA receptor antibodies. Our case extends the clinical spectrum associated with neuronal cell-surface autoantibodies to include atypical cases of TEA.
Citation
Savage S [et al]. NMDA receptor antibody encephalitis presenting as Transient Epileptic Amnesia. Journal of Neuroimmunology. 2019 Feb 15;327:41-43
Note
This article is freely available via Open Access. Click on the Publisher URL to access the full text.