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    The prognostic value of the neutrophil-to-lymphocyte ratio in patients with muscle-invasive bladder cancer treated with neoadjuvant chemotherapy and radical cystectomy

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    URI
    https://rde.dspace-express.com/handle/11287/621230
    Author
    Campain, Nicholas J
    McGrath, John S
    Aning, Jonathan
    Date
    2020-01
    Journal
    Urologic Oncology
    Type
    Journal Article
    Publisher
    Elsevier
    DOI
    10.1016/j.urolonc.2019.09.023
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    Abstract
    The neutrophil-to-lymphocyte ratio (NLR) is an attractive marker because it is derived from routine bloodwork. NLR has shown promise as a prognostic factor in muscle invasive bladder cancer (MIBC) but its value in patients receiving neoadjuvant chemotherapy (NAC) before radical cystectomy (RC) is not yet established. Since NLR is related to an oncogenic environment and poor antitumor host response, we hypothesized that a high NLR would be associated with a poor response to NAC and would remain a poor prognostic indicator in patients receiving NAC.
    Citation
    Black AJ [et al]. The prognostic value of the neutrophil-to-lymphocyte ratio in patients with muscle-invasive bladder cancer treated with neoadjuvant chemotherapy and radical cystectomy. Urologic Oncology. 2020 38(1) e17-e27
    Publisher URL
    https://linkinghub.elsevier.com/retrieve/pii/S1078-1439(19)30374-6
    Collections
    • 2020 RD&E publications
    • HeSRU publications
    • Urology (urinary tract)

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