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International classification of abdominal wall planes (ICAP) to describe mesh insertion for ventral hernia repair
(Wiley, 2020-02)Nomenclature for mesh insertion during ventral hernia repair is inconsistent and confusing. Several terms, including 'inlay', 'sublay' and 'underlay', can refer to the same anatomical planes in the indexed literature. This ... -
Definitions for loss of domain: an International Delphi Consensus of Expert Surgeons
(Springer, 2020-04)No standardized written or volumetric definition exists for 'loss of domain' (LOD). This limits the utility of LOD as a morphological descriptor and as a predictor of peri- and postoperative outcomes. Consequently, our aim ... -
Massively parallel variant characterization identifies NUDT15 alleles associated with thiopurine toxicity
(HighWire, 2020-03-10)As a prototype of genomics-guided precision medicine, individualized thiopurine dosing based on pharmacogenetics is a highly effective way to mitigate hematopoietic toxicity of this class of drugs. Recently, NUDT15 deficiency ... -
Hemorrhoid through fistula-in-ano: a rare event case
(PubMed Central, 2020-03) -
Primary care faecal calprotectin testing in children with suspected inflammatory bowel disease: a diagnostic accuracy study
(BMJ, 2020-10)Objective: To determine the diagnostic accuracy of calprotectin to diagnose inflammatory bowel disease (IBD) in children in whom general practitioners (GPs) suspected IBD. Design: Prospective observational cohort study ... -
HLA-DQA1*05 carriage associated with development of anti-drug antibodies to infliximab and adalimumab in patients with Crohn's Disease
(Elsevier, 2020-01)Anti-tumor necrosis factor (anti-TNF) therapies are the most widely used biologic drugs for treating immune-mediated diseases, but repeated administration can induce the formation of anti-drug antibodies. The ability to ... -
Real-World Effectiveness of Tofacitinib for Moderate to Severe Ulcerative Colitis: A Multi-Centre UK Experience
(Oxford University Press, 2020-04-13)Background: Tofacitinib is a partially selective Janus kinase inhibitor approved for the treatment of refractory moderate to severe ulcerative colitis (UC). We sought to define the effectiveness and adverse effects of ... -
Rectal stump management in inflammatory bowel disease: a cohort study, systematic review and proportional analysis of perioperative complications
(Springer, 2020-07)Background: The aim of this study was to analyse local single-institution data and perform a systematic review of the literature to calculate precise risk estimates of rectal stump-related morbidity and mortality following ... -
Adaptations to the British Society of Gastroenterology guidelines on the management of acute severe UC in the context of the COVID-19 pandemic: a RAND appropriateness panel
(BMJ, 2020-10)Objective: Management of acute severe UC (ASUC) during the novel COVID-19 pandemic presents significant dilemmas. We aimed to provide COVID-19-specific guidance using current British Society of Gastroenterology (BSG) ... -
British Society of Gastroenterology guidance for management of inflammatory bowel disease during the COVID-19 pandemic
(BMJ, 2020-06)The COVID-19 pandemic is putting unprecedented pressures on healthcare systems globally. Early insights have been made possible by rapid sharing of data from China and Italy. In the UK, we have rapidly mobilised inflammatory ...