Browsing 2020 RD&E publications by Title

A Comparison of Continuous Wound Infiltration Plus Patient Controlled Analgesia Versus Epidural Analgesia after Open Renal Surgery

Thompson, Elizabeth; Green, Adam; Hartsilver, Emma; Stott, Mark; Meikle, Katharine; Ormerod, Victoria; Lilaonitkul, Maytinee; Powell, Roy (Openventio, 2020-06-03)

Absence of islet autoantibodies and modestly raised glucose values at diabetes diagnosis should lead to testing for MODY: lessons from a 5 year pediatric Swedish national cohort study

Shepherd, Maggie; Ellard, Sian; Weedon, Michael; Colclough, Kevin; Hattersley, Andrew T. (American Diabetes Association, 2020-01)

Identifying maturity-onset diabetes of the young (MODY) in pediatric populations close to diabetes diagnosis is difficult. Misdiagnosis and unnecessary insulin treatment are common. We aimed to identify the discriminatory ...

Accelerating the Search for Interventions Aimed at Expanding the Health Span in Humans: The Role of Epidemiology

Melzer, David (Oxford University Press, 2020-01-01)

Background: Extensive work in basic and clinical science suggests that biological mechanisms of aging are causally related to the development of disease and disability in late life. Modulation of the biological mechanisms ...

Acquired Brown Syndrome in Head Trauma: Does Fixation of Associated Nasal and Frontal Bone Fractures Provide a Cure?

Watts, Mark; Holmes, Simon (White Rose University Press, 2020-01-30)

A 43-year-old gentleman presented with vertical double vision following nasal and frontal bone fractures resulting from blunt trauma to the glabella. Orthoptic assessment revealed a diagnosis of traumatic Brown syndrome ...

Acquired Brown Syndrome in Head Trauma: Does Fixation of Associated Nasal and Frontal Bone Fractures Provide a Cure?

Watts, Mark (White Rose University Press, 2020-01-30)

A 43-year-old gentleman presented with vertical double vision following nasal and frontal bone fractures resulting from blunt trauma to the glabella. Orthoptic assessment revealed a diagnosis of traumatic Brown syndrome ...

Activity interventions to improve the experience of care in hospital for people living with dementia: a systematic review

Gwernan-Jones, R.; Abbott, R.; Rogers, M.; Green, C.; Ball, S.; Moore, D. A.; Hemsley, Anthony; Cheeseman, Debbie (BioMed Central, 2020-04-10)

Background: An increasingly high number of patients admitted to hospital have dementia. Hospital environments can be particularly confusing and challenging for people living with dementia (Plwd) impacting their wellbeing ...

Adaptations to the British Society of Gastroenterology guidelines on the management of acute severe UC in the context of the COVID-19 pandemic: a RAND appropriateness panel

Kennedy, Nicholas A. (BMJ, 2020-10)

Objective: Management of acute severe UC (ASUC) during the novel COVID-19 pandemic presents significant dilemmas. We aimed to provide COVID-19-specific guidance using current British Society of Gastroenterology (BSG) ...

Addressing the indirect effects of COVID-19 on the health of children and young people

Chanchlani, Neil (HighWire, 2020-08-10)

Adherence and persistence to direct oral anticoagulants in atrial fibrillation: a population based study

Strain, W David (BMJ, 2020-01)

Despite simpler regimens than vitamin K antagonists (VKAs) for stroke prevention in atrial fibrillation (AF), adherence (taking drugs as prescribed) and persistence (continuation of drugs) to direct oral anticoagulants are ...

Adolescent with abdominal pain poorly responsive to analgesia

Chanchlani, Neil; Hart, James W.; McMillan, Christine; Moudiotis, Christopher (HighWire, 2020-12-16)

Case presentation A 14-year-old boy, with autism spectrum disorder, presented with a 1-day history of colicky abdominal pain, non-bilious vomiting, anorexia and loose normal-coloured stool. Two days previously, he had a ...

Advancing human health in the decade ahead: pregnancy as a key window for discovery: A Burroughs Wellcome Fund Pregnancy Think Tank

Freathy, Rachel M. (Elsevier Science, 2020-09)

Recent revolutionary advances at the intersection of medicine, omics, data sciences, computing, epidemiology, and related technologies inspire us to ponder their impact on health. Their potential impact is particularly ...

After ISCHEMIA: is invasive physiology the only remaining gatekeeper for myocardial revascularization in chronic coronary syndromes?

Kanoun, Sadeek (Springer, 2020-08)

The International Study of Comparative Health Effectiveness With Medical And Invasive Approaches (ISCHEMIA) has the potential to be a game changer in terms of the diagnostic and management approach to patients presenting ...

Agitation and impulsivity in mid and late life as possible risk markers for incident dementia

Ballard, Clive (PubMed Central, 2020-09-06)

To identify knowledge gaps regarding new-onset agitation and impulsivity prior to onset of cognitive impairment or dementia the International Society to Advance Alzheimer's Research and Treatment Neuropsychiatric Syndromes ...

Alcohol consumption, cigarette smoking, and risk of breast cancer for BRCA1 and BRCA2 mutation carriers: results from the BRCA1 and BRCA2 Cohort Consortium

Brewer, Carole (American Association for Cancer Research, 2020-02)

Tobacco smoking and alcohol consumption have been intensively studied in the general population to assess their effects on the risk of breast cancer, but very few studies have examined these effects in BRCA1 and BRCA2 ...

All thresholds of maternal hyperglycaemia from the WHO 2013 criteria for gestational diabetes identify women with a higher genetic risk for type 2 diabetes.

Hughes, Alice E.; Hayes, M. Geoffrey; Egan, Aoife M.; Patel, Kashyap A.; Scholtens, Denise M.; Lowe, Lynn P.; Lowe, William L. Jr; Dunne, Fidelma P.; Hattersley, Andrew T.; Freathy, Rachel M. (Wellcome, 2021-03-23)

Background: Using genetic scores for fasting plasma glucose (FPG GS) and type 2 diabetes (T2D GS), we investigated whether the fasting, 1-hour and 2-hour glucose thresholds from the WHO 2013 criteria for gestational ...

Along came a spider: an unusual organism identified in a peritoneal dialysis patient, a case report and literature review

Carnall, Victoria Jane; Auckland, Cressida; Mulgrew, Christopher J. (Bio Med Central, 2020-11-11)

Background: Peritoneal dialysis-associated peritonitis can uncommonly be caused by fungal infections. When they do present, they are associated with significant mortality and morbidity. We describe a case where a sample ...