Browsing 2020 RD&E publications by Title
Now showing items 1-20 of 189
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Absence of islet autoantibodies and modestly raised glucose values at diabetes diagnosis should lead to testing for MODY: lessons from a 5 year pediatric Swedish national cohort study
(American Diabetes Association, 2020-01)Identifying maturity-onset diabetes of the young (MODY) in pediatric populations close to diabetes diagnosis is difficult. Misdiagnosis and unnecessary insulin treatment are common. We aimed to identify the discriminatory ... -
Activity interventions to improve the experience of care in hospital for people living with dementia: a systematic review
(BioMed Central, 2020-04-10)Background: An increasingly high number of patients admitted to hospital have dementia. Hospital environments can be particularly confusing and challenging for people living with dementia (Plwd) impacting their wellbeing ... -
Adherence and persistence to direct oral anticoagulants in atrial fibrillation: a population based study
(BMJ, 2020-01)Despite simpler regimens than vitamin K antagonists (VKAs) for stroke prevention in atrial fibrillation (AF), adherence (taking drugs as prescribed) and persistence (continuation of drugs) to direct oral anticoagulants are ... -
Alcohol consumption, cigarette smoking, and risk of breast cancer for BRCA1 and BRCA2 mutation carriers: results from the BRCA1 and BRCA2 Cohort Consortium
(American Association for Cancer Research, 2020-02)Tobacco smoking and alcohol consumption have been intensively studied in the general population to assess their effects on the risk of breast cancer, but very few studies have examined these effects in BRCA1 and BRCA2 ... -
Amniotic band sequence in paternal half-siblings with vascular Ehlers-Danlos Syndrome
(Wiley, 2020-03)Familial amniotic band sequence (ABS) is rare but has been reported in the offspring of mothers with connective tissue disorders. We present a family of two half-siblings with ABS who share the same biological father. ... -
APOE e4 genotype predicts severe COVID-19 in the UK Biobank community cohort
(Oxford University Press, 2020-05-26) -
Assessment of a causal relationship between body mass index and atopic dermatitis
(Elsevier Science, 2020-05-17) -
Assessment of MTNR1B type 2 diabetes genetic risk modification by shift work and Morningness-Eveningness preference in the UK Biobank
(American Diabetes Association, 2020-02)Night shift work, behavioral rhythms, and the common MTNR1B risk single nucleotide polymorphism (SNP), rs10830963, associate with type 2 diabetes; however, whether they exert joint effects to exacerbate type 2 diabetes ... -
Association of genomic domains in BRCA1 and BRCA2 with prostate cancer risk and aggressiveness
(HighWire, 2020-02)Pathogenic sequence variants (PSV) in BRCA1 or BRCA2 (BRCA1/2) are associated with increased risk and severity of prostate cancer. We evaluated whether PSVs in BRCA1/2 were associated with risk of overall prostate cancer ... -
Association of maternal thyroid function with birthweight: a systematic review and individual-participant data meta-analysis
(Elsevier Science, 2020-06)Background: Adequate transplacental passage of maternal thyroid hormone is important for normal fetal growth and development. Maternal overt hypothyroidism and hyperthyroidism are associated with low birthweight, but ... -
Barriers to undertaking technical skills
(Wiley, 2020-04) -
Beta human papillomaviruses infection and skin carcinogenesis
(Wiley, 2020-07)During the last decade, the worldwide incidence of keratinocyte carcinomas (KC) has increased significantly. They are now the most common malignancy, representing approximately 30% of all cancers. The role of ultraviolet ... -
Binasal hemianopia in two sisters
(BMJ, 2020-01-21)Binasal hemianopia is a rare visual field defect. A teenage girl presented with blurred vision and persistent headaches following a minor head injury. The ocular examination was normal except for a binasal hemianopia, and ... -
Bioabsorbable mesh use in midline abdominal wall prophylaxis and repair achieving fascial closure: a cross-sectional review of stage of innovation
(Springer, 2020-05-24)Background: Achieving stable closure of complex or contaminated abdominal wall incisions remains challenging. This study aimed to characterise the stage of innovation for bioabsorbable mesh devices used during both midline ... -
Biomechanical testing of fixed and adjustable femoral cortical suspension devices for ACL reconstruction under high loads and extended cyclic loading
(Springer, 2020-05-11)Purpose: To compare loop elongation after 5000 cycles, loop-elongation at failure, and load at failure of the fixed-loop G-Lok device and three adjustable-loop devices (UltraButton, RigidLoop Adjustable and ProCinch RT), ... -
Blood pressure in frail older adults: associations with cardiovascular outcomes and all-cause mortality
(Oxford University Press, 2020-08-24)Background: Blood pressure (BP) management in frail older people is challenging. An randomised controlled trial of largely non-frail older people found cardiovascular and mortality benefit with systolic (S) BP target <120 ... -
Blood RNA analysis can increase clinical diagnostic rate and resolve variants of uncertain significance
(Nature Publishing Group, 2020-06)Purpose: Diagnosis of genetic disorders is hampered by large numbers of variants of uncertain significance (VUSs) identified through next-generation sequencing. Many such variants may disrupt normal RNA splicing. We examined ... -
Bone Marrow Oedema in the Knees of Asymptomatic High-Level Athletes: Prevalence and Associated Factors
(Indian Orthopaedics Association, 2020-02-28)Background: Bone marrow oedema (BMO), seen on magnetic resonance imaging, can be associated with various injuries to the knee but may also occur in asymptomatic athletes. The prevalence and causal factors for these ... -
British Society of Gastroenterology guidance for management of inflammatory bowel disease during the COVID-19 pandemic
(BMJ, 2020-06)The COVID-19 pandemic is putting unprecedented pressures on healthcare systems globally. Early insights have been made possible by rapid sharing of data from China and Italy. In the UK, we have rapidly mobilised inflammatory ...