Browsing 2020 RD&E publications by Title
Now showing items 1-20 of 361
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Absence of islet autoantibodies and modestly raised glucose values at diabetes diagnosis should lead to testing for MODY: lessons from a 5 year pediatric Swedish national cohort study
(American Diabetes Association, 2020-01)Identifying maturity-onset diabetes of the young (MODY) in pediatric populations close to diabetes diagnosis is difficult. Misdiagnosis and unnecessary insulin treatment are common. We aimed to identify the discriminatory ... -
Accelerating the Search for Interventions Aimed at Expanding the Health Span in Humans: The Role of Epidemiology
(Oxford University Press, 2020-01-01)Background: Extensive work in basic and clinical science suggests that biological mechanisms of aging are causally related to the development of disease and disability in late life. Modulation of the biological mechanisms ... -
Acquired Brown Syndrome in Head Trauma: Does Fixation of Associated Nasal and Frontal Bone Fractures Provide a Cure?
(White Rose University Press, 2020-01-30)A 43-year-old gentleman presented with vertical double vision following nasal and frontal bone fractures resulting from blunt trauma to the glabella. Orthoptic assessment revealed a diagnosis of traumatic Brown syndrome ... -
Activity interventions to improve the experience of care in hospital for people living with dementia: a systematic review
(BioMed Central, 2020-04-10)Background: An increasingly high number of patients admitted to hospital have dementia. Hospital environments can be particularly confusing and challenging for people living with dementia (Plwd) impacting their wellbeing ... -
Adaptations to the British Society of Gastroenterology guidelines on the management of acute severe UC in the context of the COVID-19 pandemic: a RAND appropriateness panel
(BMJ, 2020-10)Objective: Management of acute severe UC (ASUC) during the novel COVID-19 pandemic presents significant dilemmas. We aimed to provide COVID-19-specific guidance using current British Society of Gastroenterology (BSG) ... -
Addressing the indirect effects of COVID-19 on the health of children and young people
(HighWire, 2020-08-10) -
Adherence and persistence to direct oral anticoagulants in atrial fibrillation: a population based study
(BMJ, 2020-01)Despite simpler regimens than vitamin K antagonists (VKAs) for stroke prevention in atrial fibrillation (AF), adherence (taking drugs as prescribed) and persistence (continuation of drugs) to direct oral anticoagulants are ... -
Advancing human health in the decade ahead: pregnancy as a key window for discovery: A Burroughs Wellcome Fund Pregnancy Think Tank
(Elsevier Science, 2020-09)Recent revolutionary advances at the intersection of medicine, omics, data sciences, computing, epidemiology, and related technologies inspire us to ponder their impact on health. Their potential impact is particularly ... -
After ISCHEMIA: is invasive physiology the only remaining gatekeeper for myocardial revascularization in chronic coronary syndromes?
(Springer, 2020-08)The International Study of Comparative Health Effectiveness With Medical And Invasive Approaches (ISCHEMIA) has the potential to be a game changer in terms of the diagnostic and management approach to patients presenting ... -
Alcohol consumption, cigarette smoking, and risk of breast cancer for BRCA1 and BRCA2 mutation carriers: results from the BRCA1 and BRCA2 Cohort Consortium
(American Association for Cancer Research, 2020-02)Tobacco smoking and alcohol consumption have been intensively studied in the general population to assess their effects on the risk of breast cancer, but very few studies have examined these effects in BRCA1 and BRCA2 ... -
Altered DNA methylation profiles in blood from patients with sporadic Creutzfeldt-Jakob disease
(Springer, 2020-12)Prion diseases are fatal and transmissible neurodegenerative disorders caused by the misfolding and aggregation of prion protein. Although recent studies have implicated epigenetic variation in common neurodegenerative ... -
Amniotic band sequence in paternal half-siblings with vascular Ehlers-Danlos Syndrome
(Wiley, 2020-03)Familial amniotic band sequence (ABS) is rare but has been reported in the offspring of mothers with connective tissue disorders. We present a family of two half-siblings with ABS who share the same biological father. ... -
Annotating high-impact 5'untranslated region variants with the UTRannotator
(Oxford University Press, 2020-09-14)Summary: Current tools to annotate the predicted effect of genetic variants are heavily biased towards protein-coding sequence. Variants outside of these regions may have a large impact on protein expression and/or structure ... -
Anti-interleukin-5 therapy in patients with severe asthma: from clinical trials to clinical practice
(Elsevier Science, 2020-05) -
Antipsychotic use in dementia: the relationship between neuropsychiatric symptom profiles and adverse outcomes
(Springer, 2020-05-15)Antipsychotic treatments are associated with safety concerns in people with dementia. The authors aimed to investigate whether risk of adverse outcomes related to antipsychotic prescribing differed according to major ... -
ApoE e2 and aging-related outcomes in 379,000 UK Biobank participants
(Impact Journals, 2020-06-08)The Apolipoprotein E (APOE) e4 allele is associated with reduced longevity and increased Coronary Artery Disease (CAD) and Alzheimer's disease, with e4e4 having markedly larger effect sizes than e3e4. The e2 longevity ... -
APOE e4 genotype predicts severe COVID-19 in the UK Biobank community cohort
(Oxford University Press, 2020-05-26) -
ApoE e4e4 Genotype and Mortality With COVID-19 in UK Biobank
(Silverchair Information Systems, 2020-09-16) -
Applying gene-editing technology to elucidate the functional consequence of genetic and epigenetic variation in Alzheimer's disease
(Wiley, 2020-09)Recent studies have highlighted a potential role of genetic and epigenetic variation in the development of Alzheimer's disease. Application of the CRISPR-Cas genome-editing platform has enabled investigation of the functional ... -
Assessing effector T cells in type 1 diabetes
(Wolters Kluwer Health, Inc., 2020-08)Purpose of review: The role of T cells specific for islet autoantigens is proven in pathogenesis of type 1 diabetes. Recently, there has been rapid expansion in the number of T-cell subsets identified, this has coincided ...