• Common maternal and fetal genetic variants show expected polygenic effects on risk of small- or large-for-gestational-age (SGA or LGA), except in the smallest 3% of babies 

  Beaumont, Robin N.; Wood, A. R.; Knight, Bridget A.; Hattersley, Andrew T.; Freathy, Rachel M. (Public Library of Science, 2020-12-07)

  Babies born clinically Small- or Large-for-Gestational-Age (SGA or LGA; sex- and gestational age-adjusted birth weight (BW) <10th or >90th percentile, respectively), are at higher risks of complications. SGA and LGA include ...

• Online Education and Cognitive Behavior Therapy Improve Dementia Caregivers' Mental Health: A Randomized Trial 

  Ballard, Clive (Elsevier Science, 2020-12-04)

  Objectives: To compare online cognitive-behavioral therapy (CBT) with and without telephone support respectively to online psychoeducation in a randomized controlled trial (RCT) in caregivers of people with dementia with ...

• Adolescent with abdominal pain poorly responsive to analgesia 

  Chanchlani, Neil; Hart, James W.; McMillan, Christine; Moudiotis, Christopher (HighWire, 2020-12-16)

  Case presentation A 14-year-old boy, with autism spectrum disorder, presented with a 1-day history of colicky abdominal pain, non-bilious vomiting, anorexia and loose normal-coloured stool. Two days previously, he had a ...

• A Comparison of the Real-Life Clinical Effectiveness of the Leading Licensed ICS/LABA Combination Inhalers in the Treatment for COPD 

  Halpin, David M (Dove Medical Press, 2020-11-26)

  Introduction: The Fostair® 100/6 (BDP/FF) pressurized metered-dose inhaler, delivering an extrafine formulation, is licensed for asthma and COPD in the UK. However, its real-life effectiveness for COPD has not been evaluated. ...

• Managing nonspecific abdominal pain in children and young people 

  Chanchlani, Neil (HighWire, 2020-11-30)

• Patterns of Mitochondrial TSPO Binding in Cerebral Small Vessel Disease: An in vivo PET Study With Neuropathological Comparison 

  Ballard, Clive (Frontiers Media, 2020-10-16)

  Small vessel disease (SVD) is associated with cognitive impairment in older age and be implicated in vascular dementia. Post-mortem studies show proliferation of activated microglia in the affected white matter. However, ...

• Is disrupted sleep a risk factor for Alzheimer's disease? Evidence from a two-sample Mendelian randomization analysis 

  Jones, S. E.; Beaumont, Robin N.; Tyrrell, Jessica; Frayling, Timothy M.; Wood, A. R.; Weedon, M. N. (Silverchair, 2020-11-05)

  Background: It is established that Alzheimer's disease (AD) patients experience sleep disruption. However, it remains unknown whether disruption in the quantity, quality or timing of sleep is a risk factor for the onset ...

• The feasibility of online video calling to engage patients with cystic fibrosis in exercise training 

  Tomlinson, O. W.; Shelley, James; Trott, Jayne; Bowhay, Ben; Chauhan, Rohan; Sheldon, Christopher David (Atypon, 2020-07)

  Introduction: Physical activity, including structured exercise, is an essential component in the management of cystic fibrosis. The use of telehealth such as video-calling may be a useful method for the delivery of exercise ...

• YIPF5 mutations cause neonatal diabetes and microcephaly through endoplasmic reticulum stress 

  De Franco, Elisa; Wakeling, M. N.; Ellard, Sian; Hattersley, Andrew T.; Patel, Kashyap; Laver, T. W.; Johnson, M. B.; Flanagan, Sarah (American Society for Clinical Investigation, 2020-12-01)

  Neonatal diabetes is caused by single gene mutations reducing pancreatic β cell number or impairing β cell function. Understanding the genetic basis of rare diabetes subtypes highlights fundamental biological processes in ...

• Paired rRNA-depleted and polyA-selected RNA sequencing data and supporting multi-omics data from human T cells 

  Frontini, Mattia (Nature Publishing Group, 2020-11-09)

  Both poly(A) enrichment and ribosomal RNA depletion are commonly used for RNA sequencing. Either has its advantages and disadvantages that may lead to biases in the downstream analyses. To better access these effects, we ...

• Datasets of whole cell and mitochondrial oxysterols derived from THP-1, SH-SY5Y and human peripheral blood mononuclear cells using targeted metabolomics 

  Rickman, Olivia J.; Voutsina, Nikol; Baple, Emma L.; Crosby, Andrew H. (Elsevier Science, 2020-10-16)

  The raw datasets of oxysterol quantifications from whole cell and mitochondrial fractions of THP-1 monocytes and macrophages, neuronal-like SH-SH5Y cells and human peripheral blood mononuclear cells are presented. Oxysterols ...

• Sex-specific outcome disparities in very old patients admitted to intensive care medicine: a propensity matched analysis 

  Boulanger, Carole (Nature Publishing Group, 2020-10-29)

  Female and male very elderly intensive patients (VIPs) might differ in characteristics and outcomes. We aimed to compare female versus male VIPs in a large, multinational collective of VIPs with regards to outcome and ...

• Robotic-Assisted Patellofemoral Replacement-Correlation of Preoperative Planning with Intraoperative Implant Position and Early Clinical Experience: A Minimum 2-Year Follow-up 

  Selvaratnam, Veenesh; Eyres, Keith; Toms, Andrew D.; Phillips, Jonathan R.; Mandalia, Vipul (Thieme Medical Publishers, 2020-10-30)

  Patello-femoral arthroplasty (PFA) is successful in a selected group of patients and yields a good functional outcome. Robotic-assisted knee arthroplasty has been shown to provide better implant positioning and alignment. ...

• Full-thickness Skin Graft Fixation Techniques: A Review of the Literature 

  Xie, Fangyi (PubMed Central, 2020-07)

  Multiple techniques for skin graft fixation have been proposed, but the evidence underlying these techniques is unclear. This study aimed to review the literature for full-thickness graft fixation techniques. PubMed was ...

• Screening and Intervention to Prevent Falls and Fractures in Older People 

  Lamb, S. E.; Hulme, C; Sheridan, Ray (Atypon, 2020-11-05)

  Background: Community screening and therapeutic prevention strategies may reduce the incidence of falls in older people. The effects of these measures on the incidence of fractures, the use of health resources, and ...

• Periprosthetic joint infection in the knee - Criteria for the management of PJI 

  Phillips, Jonathan R. A.; Toms, Andrew D. (Elsevier Science, 2020-12)

• Patellotrochlea Index in Normal Healthy Knees 

  Middleton, S.; Bajada, Stefan; Powell, Roy; Nelson, A.; Mandalia, Vipul (Thieme Medical Publishers, 2020-11-23)

  Patella alta is a common and significant abnormality responsible for many patellofemoral joint-related conditions. Many methods of patella height measurements are described; however, patellotrochear index (PTI) is the most ...

• Association of Hemochromatosis HFE p.C282Y Homozygosity With Hepatic Malignancy 

  Atkins, J. L.; Pilling, L. C.; Masoli, Jane A.; Melzer, David (Silverchair, 2020-11-24)

  Importance: Hereditary hemochromatosis is predominantly caused by the HFE p.C282Y homozygous pathogenic variant. Liver carcinoma and mortality risks are increased in individuals with clinically diagnosed hereditary ...

• KMT2B-related disorders: expansion of the phenotypic spectrum and long-term efficacy of deep brain stimulation 

  Rankin, Julia; Baple, Emma L. (Oxford University Press, 2020-12-05)

  Heterozygous mutations in KMT2B are associated with an early-onset, progressive and often complex dystonia (DYT28). Key characteristics of typical disease include focal motor features at disease presentation, evolving ...

• Neoadjuvant chemotherapy plus radical cystectomy versus radical cystectomy alone in clinical T2 bladder cancer without hydronephrosis 

  McGrath, John S (Wiley, 2020-11-05)

  Objectives: To assess the efficacy of neoadjuvant chemotherapy (NAC) before radical cystectomy (RC) in a retrospective multicentre cohort of patients with cT2N0M0 bladder cancer (BCa) without preoperative hydronephrosis. ...

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