• A Non-Coding Disease Modifier of Pancreatic Agenesis Identified by Genetic Correction in a Patient-Derived iPSC Line 

  De Franco, Elisa; Hattersley, Andrew T. (Elsevier Science, 2020-07-02)

  GATA6 is a critical regulator of pancreatic development, with heterozygous mutations in this transcription factor being the most common cause of pancreatic agenesis. To study the variability in disease phenotype among ...

• Late-onset Pseudoxanthoma Elasticum Associated with a Hypomorphic ABCC6 Variant 

  Tysoe, Carolyn; Caswell, Richard (Elsevier Science, 2020-10)

  Purpose: To describe patients with late-onset pseudoxanthoma elasticum (PXE) associated with a likely hypomorphic ABCC6 variant. Design: Retrospective observational case series. Methods: Clinical evaluation, multimodal ...

• An integrated multi-omics approach identifies the landscape of interferon-α-mediated responses of human pancreatic beta cells 

  Hill, J. L. E.; Russell, M. A.; Richardson, S. J.; Morgan, Noel (Nature Publishing Group, 2-05-22)

  Interferon-α (IFNα), a type I interferon, is expressed in the islets of type 1 diabetic individuals, and its expression and signaling are regulated by T1D genetic risk variants and viral infections associated with T1D. We ...

• Risk factors for genital infections in people initiating SGLT2 inhibitors and their impact on discontinuation 

  Shields, Beverley M; Hattersley, Andrew T.; Jones, Angus G.; Dennis, J. M. (BMJ, 2020-05)

  Introduction: To identify risk factors, absolute risk, and impact on treatment discontinuation of genital infections with sodium-glucose co-transporter-2 inhibitors (SGLT2i). Research design and methods: We assessed the ...

• Primary care faecal calprotectin testing in children with suspected inflammatory bowel disease: a diagnostic accuracy study 

  Walker, Gareth; Chanchlani, Neil; Thomas, Amanda; Lin, Simeng; Moore, Lucy; Heerasing, Neel; Hendy, Peter; Abdelrahim, Mohamad; Mole, Sean; Perry, Mandy; McDonald, Timothy J.; Bewshea, Claire M.; Hart, James W.; Ahmad, Tariq; Goodhand, James R.; Kennedy, Nicholas A. (BMJ, 2020-10)

  Objective: To determine the diagnostic accuracy of calprotectin to diagnose inflammatory bowel disease (IBD) in children in whom general practitioners (GPs) suspected IBD. Design: Prospective observational cohort study ...

• Immune checkpoint inhibitor induced large vessel vasculitis 

  Sankey, Peter (BMJ, 2020-05-18)

  This is a case report of a 67-year-old patient with castration resistant metastatic prostate cancer who developed an immune-mediated large vessel vasculitis following treatment with ipilimumab (anti-CTLA-4) and nivolumab ...

• The genetics of human ageing 

  Melzer, David; Pilling, L. C. (Nature Publishing Group, 2020-02)

  The past two centuries have witnessed an unprecedented rise in human life expectancy. Sustaining longer lives with reduced periods of disability will require an understanding of the underlying mechanisms of ageing, and ...

• Lower cognitive baseline scores predict cognitive training success after 6 months in healthy older adults: Results of an online RCT 

  Corbett, Anne; Ballard, Clive (Wiley, 2020-09)

  Background: Identifying predictors for general cognitive training (GCT) success in healthy older adults has many potential uses, including aiding intervention and improving individual dementia risk prediction, which are ...

• Quantification of the pace of biological aging in humans through a blood test, the DunedinPoAm DNA methylation algorithm 

  Hannon, Eilis; Mill, Jonathan (eLife Sciences Publications Ltd., 2020-05-05)

  Biological aging is the gradual, progressive decline in system integrity that occurs with advancing chronological age, causing morbidity and disability. Measurements of the pace of aging are needed as surrogate endpoints ...

• The impact of an integrated heart failure service in a medium-sized district general hospital 

  Hawley, Alasdair; He, Jingzhou (BMJ, 2020-05)

  Objectives: Assessing the impact of a new integrated heart failure service (IHFS) in a medium-sized district general hospital (DGH) on heart failure (HF) mortality, readmission rates, and provision of HF care. Methods: ...

• Biomechanical testing of fixed and adjustable femoral cortical suspension devices for ACL reconstruction under high loads and extended cyclic loading 

  Singh, Sarvpreet; Schranz, Peter J.; Mandalia, Vipul (Springer, 2020-05-11)

  Purpose: To compare loop elongation after 5000 cycles, loop-elongation at failure, and load at failure of the fixed-loop G-Lok device and three adjustable-loop devices (UltraButton, RigidLoop Adjustable and ProCinch RT), ...

• Conservative management of oesophageal soft food bolus impaction 

  Smith, Joel (Wiley, 2020-05-11)

  Background: Impaction of a soft food bolus in the oesophagus causes dysphagia and regurgitation. If the bolus does not pass spontaneously, then the patient is at risk of aspiration, dehydration, perforation, and death. ...

• Limit of detection of troponin discharge strategy versus usual care: randomised controlled trial 

  Reuben, Adam (BMJ, 2020-10)

  Introduction: The clinical effectiveness of a 'rule-out' acute coronary syndrome (ACS) strategy for emergency department patients with chest pain, incorporating a single undetectable high-sensitivity cardiac troponin ...

• Medical education during the COVID-19 pandemic: perspectives from UK trainees 

  Xie, Fangyi (BMJ, 2020-07)

• The experiences of hospital staff who provide care for people living with dementia: A systematic review and synthesis of qualitative studies 

  Gwernan-Jones, R.; Abbott, R.; Rogers, M.; Green, C.; Ball, S.; Hemsley, Anthony; Cheeseman, Debbie; Moore, D. A.; Thompson Coon, J. (Wiley, 2020-05-15)

  Aims and objectives: To systematically review and synthesise qualitative data from studies exploring the experiences of hospital staff who care for people living with dementia (Plwd). Background: In hospital, the number ...

• Does Obesity Cause Thyroid Cancer? A Mendelian Randomization Study 

  Fussey, Jonathan Mark; Beaumont, Robin N.; Wood, Andrew R; Vaidya, Bijay; Smith, Joel; Tyrrell, Jessica (Oxford University Press, 2020-07-01)

  Background: The incidence of thyroid cancer is rising, and relatively little is known about modifiable risk factors for the condition. Observational studies have suggested a link between adiposity and thyroid cancer; ...

• Bone Marrow Oedema in the Knees of Asymptomatic High-Level Athletes: Prevalence and Associated Factors 

  Mandalia, Vipul; Kosy, Jonathan D.; Schranz, Peter; Redfern, Andrew; Silver, David; Powell, Roy; Williams, Craig A. (Indian Orthopaedics Association, 2020-02-28)

  Background: Bone marrow oedema (BMO), seen on magnetic resonance imaging, can be associated with various injuries to the knee but may also occur in asymptomatic athletes. The prevalence and causal factors for these ...

• Suture fixation versus self-gripping mesh for open inguinal hernia repair: a systematic review with meta-analysis and trial sequential analysi 

  Bullen, N L; Smart, Neil J. (Springer, 2020-05-22)

  Introduction: Morbidity following open inguinal hernia repair is mainly related to chronic pain. ProGrip™ is a self-gripping mesh which aims to reduce rates of chronic pain. The aim of this study is to perform an update ...

• Association of maternal thyroid function with birthweight: a systematic review and individual-participant data meta-analysis 

  Vaidya, Bijay; Knight, Bridget (Elsevier Science, 2020-06)

  Background: Adequate transplacental passage of maternal thyroid hormone is important for normal fetal growth and development. Maternal overt hypothyroidism and hyperthyroidism are associated with low birthweight, but ...

• The cost of providing mechanical thrombectomy in the UK NHS: a micro-costing study 

  James, Martin (HighWire, 2020-05)

  Introduction: The clinical efficacy and cost-effectiveness of mechanical thrombectomy (MT) for the treatment of large vessel occlusion stroke is well established, but uncertainty remains around the true cost of delivering ...

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