• A comparison of femoral tunnel placement in ACL reconstruction using a 70° arthroscope through the anterolateral portal versus a 30° arthroscope through the anteromedial portal: a pilot 3D-CT study 

  Kosy, Jonathan D.; Walmsley, Katie; Gordon, Elizabeth A.; Heddon, Sadie V.; Anaspure, Rahul; Schranz, Peter J.; Mandalia, Vipul (Inforang, 2020-04-03)

  Background: Graft malposition is a risk factor for failure of anterior cruciate ligament reconstruction. A 70° arthroscope improves visualisation of the medial wall of the lateral femoral condyle without switching portals. ...

• Ten-Year Results of FAST: A Randomized Controlled Trial of 5-Fraction Whole-Breast Radiotherapy for Early Breast Cancer 

  Goodman, Andrew (Atypon, 2020-10-01)

  Purpose: Previous studies of hypofractionated adjuvant whole-breast radiotherapy for early breast cancer established a 15- or 16-fraction (fr) regimen as standard. The FAST Trial (CRUKE/04/015) evaluated normal tissue ...

• Assessing effector T cells in type 1 diabetes 

  Eichmann, M. (Wolters Kluwer Health, Inc., 2020-08)

  Purpose of review: The role of T cells specific for islet autoantigens is proven in pathogenesis of type 1 diabetes. Recently, there has been rapid expansion in the number of T-cell subsets identified, this has coincided ...

• Histological validation of a type 1 diabetes clinical diagnostic model for classification of diabetes 

  Carr, A. L. J.; Flaxman, Christine; Sharp, S. A.; Jones, A. G.; Richardson, S. J.; Shields, Beverley M.; Oram, Richard A. (Wiley, 2020-07-07)

  Aims: Misclassification of diabetes is common due to an overlap in the clinical features of type 1 and type 2 diabetes. Combined diagnostic models incorporating clinical and biomarker information have recently been developed ...

• Prognostic imaging biomarkers for diabetic kidney disease (iBEAt): study protocol 

  Gooding, Kim M.; Ball, Claire; Gilchrist, Mark; Shore, Angela (BioMed Central, 2020-06-29)

  Background: Diabetic kidney disease (DKD) remains one of the leading causes of premature death in diabetes. DKD is classified on albuminuria and reduced kidney function (estimated glomerular filtration rate (eGFR)) but ...

• Predicting post one-year durability of glucose-lowering monotherapies in patients with newly-diagnosed type 2 diabetes mellitus - A MASTERMIND precision medicine approach (UKPDS 87) 

  Hattersley, Andrew T.; Jones, Angus G.; Shields, Beverley M. (Elsevier Science, 2020-08)

  Aims: Predicting likely durability of glucose-lowering therapies for people with type 2 diabetes (T2D) could help inform individualised therapeutic choices. Methods: We used data from UKPDS patients with newly-diagnosed ...

• A Novel HNF4A Mutation Causing Three Phenotypic Forms of Glucose Dysregulation in a Family 

  Flanagan, Sarah (Frontiers Media SA, 2020-06-26)

  Maturity-onset diabetes of the young (MODY) classically describes dominantly inherited forms of monogenic diabetes diagnosed before 25 years of age due to pancreatic β-cell dysfunction. In contrast, mutations in certain ...

• The first knee prosthesis to go through beyond compliance: A new standard for the safe introduction of orthopaedic implants 

  Patel, Nimesh; Phillips, Jonathan R. A.; Toms, Andrew D. (Elsevier Science, 2020-12)

  Introduction: Beyond Compliance (BC) was introduced in 2012 to improve the monitoring and regulation of new medical devices and techniques, ensuring patient safety whilst promoting innovation through an evidence based ...

• The Pathfields Tool: a frailty case-finding tool using primary care IT-implications for population health management 

  Hope, Suzy (Silverchair Information Systems, 2020-10-23)

  Background: older people living with frailty benefit from targeted interventions which improve health and independence. However, it has been challenging within primary care to systematically identify patients living with ...

• Characteristic Needle-Shaped Pattern Seen on OCT in a Patient with Ocular Amyloidosis 

  Tasiopoulou, Anastasia (Elsevier Science, 2020-07-16)

• Improving understanding of type 2 diabetes remission: research recommendations from Diabetes UK's 2019 remission workshop 

  Andrews, Rob (Wiley, 2020-11)

  Aim: To describe the process and outputs of a workshop convened to identify key priorities for future research in the area of remission of type 2 diabetes, and provide recommendations to researchers and research funders ...

• Snapshot PCR surveillance for SARS-CoV-2 in hospital staff in England 

  Auckland, Cressida; Poznalska, Gosia; Roberts, Stella (Elsevier Science, 2020-09)

  Background: Significant nosocomial transmission of SARS-CoV-2 has been demonstrated. Understanding the prevalence of SARS-CoV-2 carriage amongst HCWs at work is necessary to inform the development of HCW screening programmes ...

• Preexisting Comorbidities Predicting COVID-19 and Mortality in the UK Biobank Community Cohort 

  Atkins, J. L.; Masoli, Jane A.; Delgado, J.; Pilling, L. C.; Melzer, David (Silverchair Information Systems, 2020-10-15)

  Background: Hospitalized COVID-19 patients tend to be older and frequently have hypertension, diabetes, or coronary heart disease, but whether these comorbidities are true risk factors (ie, more common than in the general ...

• Benign Prostatic Hyperplasia 

  Ng, Michael (StatPearls Publishing, 2020-01)

  Benign prostatic hyperplasia (BPH) refers to the nonmalignant growth or hyperplasia of prostate tissue and is a common cause of lower urinary tract symptoms in men. Disease prevalence has been shown to increase with advancing ...

• Cerebral arteriopathy associated with heterozygous variants in the casitas B-lineage lymphoma gene 

  Rankin, Julia (Wolters Kluwer Health, Inc., 2020-06-10)

  Objective: To report a series of patients with cerebral arteriopathy associated with heterozygous variants in the casitas B-lineage lymphoma (CBL) gene and examine the functional role of the identified mutant Cbl protein. ...

• British Gynaecological Cancer Society (BGCS) vulval cancer guidelines: Recommendations for practice 

  Edey, Katharine A. (Elsevier Science, 2020-09)

  The purpose of this guideline is to collate evidence and propose evidence-based guidelines for the diagnosis and management of adult patients with vulva carcinoma treated in the UK. Malignant melanoma may present via similar ...

• Colles' type distal radial fractures undergoing manipulation in the ED: a multicentre observational cohort study 

  Malik, Hamza; Appelboam, Andrew (HighWire, 2020-08)

  Background: Colles' type fractures of the distal radius are one of the most commonly manipulated fractures in the ED. Local audit data suggest that a high proportion of these injuries undergo subsequent surgical fixation. ...

• ApoE e4e4 Genotype and Mortality With COVID-19 in UK Biobank 

  Pilling, L. C.; Atkins, J. L.; Masoli, Jane A.; Delgado, J.; Melzer, David (Silverchair Information Systems, 2020-09-16)

• A Global, Prospective, Observational Study Measuring Disease Burden and Suffering in Patients with Ulcerative Colitis Using the Pictorial Representation of Illness and Self-Measure Tool 

  Ahmad, Tariq (Silverchair Information Systems, 2020-07-29)

  Background: The understanding the Impact of ulcerative COlitis aNd Its assoCiated disease burden on patients study [ICONIC] was a 2-year, global, prospective, observational study evaluating the cumulative burden of ulcerative ...

• Mapping UK mental health services for adults with attention-deficit/hyperactivity disorder: national survey with comparison of reporting between three stakeholder groups 

  Janssens, A.; Newlove-Delgado, T. V.; Logan, Stuart (Cambridge University Press, 2020-07-29)

  Background: UK clinical guidelines recommend treatment of attention-deficit hyperactivity disorder (ADHD) in adults by suitably qualified clinical teams. However, young people with ADHD attempting the transition from ...

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