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dc.contributor.authorClarke, Andrew
dc.identifier.citationMeakin JR, Hopkins SJ, Clarke A. In vivo assessment of thoracic vertebral shape from MRI data using a shape model. Spine Deformity. 2019 Jul;7(4):517-524en_US
dc.description.abstractSTUDY DESIGN: Feasibility study on characterizing thoracic vertebral shape from magnetic resonance images using a shape model. OBJECTIVES: Assess the reliability of characterizing thoracic vertebral shape from magnetic resonance images and estimate the normal variation in vertebral shape using a shape model. SUMMARY OF BACKGROUND DATA: The characterization of thoracic vertebra shape is important for understanding the initiation and progression of deformity and in developing surgical methods. Methods for characterizing shape need to be comprehensive, reliable, and suitable for use in vivo. METHODS: Magnetic resonance images of the thoracic vertebrae were acquired from 20 adults. Repeat scans were acquired, after repositioning the participants, for T4, T8, and T12. Landmark points were placed around the vertebra on the images and used to create a shape model. The reliability was assessed using relative error (E%) and intraclass correlation (ICC). The effect of vertebral level, sex and age on vertebral shape was assessed using repeated measures analysis of variance. RESULTS: Five modes of variation were retained from the shape model. Reliability was excellent for the first two modes (mode 1: E% = 7, ICC = 0.98; mode 2: E% = 11, ICC = 0.96). These modes described variation in the vertebral bodies, the pedicle width and orientation, and the facet joint position and orientation with respect to the pedicle axis. Variation in vertebral shape was found along the thoracic spine and between individuals, but there was little effect of age and sex. CONCLUSIONS: Magnetic resonance images and shape modeling provides a reliable method for characterizing vertebral shape in vivo. The method is able to identify differences between vertebral levels and between individuals. The use of these methods may be advantageous for performing repeated measurements in longitudinal studies. LEVEL OF EVIDENCE: N/A.en_US
dc.subjectWessex Classification Subject Headings::Orthopaedicsen_US
dc.titleIn vivo assessment of thoracic vertebral shape from MRI data using a shape modelen_US
dc.typeJournal Articleen_US
dc.identifier.journalSpine Deformityen_US
dc.description.admin-noteAccepted manuscript 12 month embargo. CC-BY-NC-ND licence required.en_US

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