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dc.contributor.authorEdey, Katharine A.
dc.identifier.citationEdey K [et al]. Interventions for the treatment of Paget's disease of the vulva. Cochrane Database of Systematic Reviews. 2019 June 5en_US
dc.description.abstractThis is an updated version of the original Cochrane Review published in Issue 10, 2013.Extramammary Paget's disease is a rare form of superficial skin cancer. The most common site of involvement is the vulva. It is seen mainly in postmenopausal white women. Paget's disease of the vulva often spreads in an occult fashion, with margins extending beyond the apparent edges of the lesion. There is a range of interventions from surgical to non-invasive techniques or treatments. The challenges of interventions are to remove or treat disease that may not be visible, without overtreatment and with minimisation of morbidity from radical surgery. There is little consensus regarding treatment. Surgery, by default, is the most common treatment, but it is challenging to excise the disease adequately, and recurrence is common, leading to repeated operations, and destruction of anatomy. Alternative treatments of photodynamic therapy, laser therapy, radiotherapy, topical treatments or even chemotherapy have been mooted, and it is important to evaluate the available evidence. It is essential to assess whether newer cell-specific treatments, such as photodynamic therapy and imiquimod, can reduce the need for radical surgery.en_US
dc.subjectWessex Classification Subject Headings::Gynaecologyen_US
dc.titleInterventions for the treatment of Paget's disease of the vulvaen_US
dc.typeJournal Articleen_US
dc.typeSystematic reviewen_US
dc.identifier.journalCochrane Database of Systematic Reviewsen_US

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