Show simple item record

dc.contributor.authorHattersley, Andrew T.en
dc.date.accessioned2019-01-09T14:50:12Z
dc.date.available2019-01-09T14:50:12Z
dc.date.issued2018-11
dc.identifier.citationBowman P, Flanagan SE, Hattersley AT. Future Roadmaps for Precision Medicine Applied to Diabetes: Rising to the Challenge of Heterogeneity. 2018, 2018:3061620 Journal of Diabetes Resen
dc.identifier.issn2314-6753
dc.identifier.pmid30599002
dc.identifier.doi10.1155/2018/3061620
dc.identifier.urihttp://hdl.handle.net/11287/620945
dc.description.abstractPrecision medicine, the concept that specific treatments can be targeted to groups of individuals with specific genetic, cellular, or molecular features, is a key aspect of modern healthcare, and its use is rapidly expanding. In diabetes, the application of precision medicine has been demonstrated in monogenic disease, where sulphonylureas are used to treat patients with neonatal diabetes due to mutations in ATP-dependent potassium (KATP) channel genes. However, diabetes is highly heterogeneous, both between and within polygenic and monogenic subtypes. Making the correct diagnosis and using the correct treatment from diagnosis can be challenging for clinicians, but it is crucial to prevent long-term morbidity and mortality. To facilitate precision medicine in diabetes, research is needed to develop a better understanding of disease heterogeneity and its impact on potential treatments for specific subtypes. Animal models have been used in diabetes research, but they are not translatable to humans in the majority of cases. Advances in molecular genetics and functional laboratory techniques and availability and sharing of large population data provide exciting opportunities for human studies. This review will map the key elements of future diabetes research in humans and its potential for clinical translation to promote precision medicine in all diabetes subtypes.en
dc.language.isoenen
dc.publisherHindawien
dc.relation.urlhttps://dx.doi.org/10.1155/2018/3061620en
dc.rightsArchived with thanks to Journal of diabetes research. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.en
dc.subjectWessex Classification Subject Headings::Endocrinology::Diabetesen
dc.titleFuture Roadmaps for Precision Medicine Applied to Diabetes: Rising to the Challenge of Heterogeneity.en
dc.typeJournal Articleen
dc.identifier.journalJournal of diabetes researchen
dc.description.noteThis article is freely available online via Open Access.en
dc.type.versionPublisheden


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record