Browsing 2019 RD&E publications by Title
Now showing items 2-21 of 367
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The acute transcriptional response to resistance exercise: impact of age and contraction mode
(Impact Journals, 2019-04-15)Optimization of resistance exercise (RE) remains a hotbed of research for muscle building and maintenance. However, the interactions between the contractile components of RE (i.e. concentric (CON) and eccentric (ECC)) and ... -
Age-related neurochemical and behavioural changes in D409V/WT GBA1 mouse: Relevance to lewy body dementia
(Elsevier Science, 2019-10)Heterozygous mutations in GBA1, the gene which encodes the lysosomal enzyme glucocerebrosidase (GCase), are a strong genetic risk factor for the development of Lewy body dementia (LBD). Until this point however, recapitulation ... -
The Agreement Between the Referrer, Practitioner and Research Diagnosis of Autistic Spectrum Conditions Among Children Attending Child and Adolescent Mental Health Services
(Springer, 2019-09)We aimed to explore the levels of agreement about the diagnoses of Autistic Spectrum Conditions between the referrer, CAMHS practitioner and a research diagnosis, as well as the stability of the practitioner's diagnosis ... -
Airway management of patients with life threatening haemorrhage: principles of safe and effective care
(Springer, 2019-08)Airway care of the patient with life threatening haemorrhage presents many challenges during damage control resuscitation. The essential requirements are to maintain oxygenation at all stages of care and when necessary ... -
Algorithmic versus expert human interpretation of instantaneous wave-free ratio coronary pressure-wire pull back data
(Elsevier, 2019-07)The aim of this study was to investigate whether algorithmic interpretation (AI) of instantaneous wave-free ratio (iFR) pressure-wire pull back data would be noninferior to expert human interpretation. -
Alzheimer's Disease associated genes ankyrin and tau cause shortened lifespan and memory loss in Drosophila
(Open Access Frontiers, 2019-06)Alzheimer's disease (AD) is the most common form of dementia and is characterized by intracellular neurofibrillary tangles of hyperphosphorylated Tau, including the 0N4R isoform and accumulation of extracellular amyloid ... -
Alzheimer’s disease-associated (hydroxy)methylomic changes in the brain and blood
(Biomed Central, 2019-11)Late-onset Alzheimer's disease (AD) is a complex multifactorial affliction, the pathogenesis of which is thought to involve gene-environment interactions that might be captured in the epigenome. The present study investigated ... -
An Amish founder variant consolidates disruption of CEP55 as a cause of hydranencephaly and renal dysplasia
(Nature, 2019-04)The centrosomal protein 55 kDa (CEP55 (OMIM 610000)) plays a fundamental role in cell cycle regulation and cytokinesis. However, the precise role of CEP55 in human embryonic growth and development is yet to be fully defined. ... -
AMPA receptor GluA2 subunit defects are a cause of neurodevelopmental disorders
(Nature, 2019-07)AMPA receptors (AMPARs) are tetrameric ligand-gated channels made up of combinations of GluA1-4 subunits encoded by GRIA1-4 genes. GluA2 has an especially important role because, following post-transcriptional editing at ... -
Analysis of serum Hsp90 as a potential biomarker of β cell autoimmunity in type 1 diabetes
(PLoS One, 2019-01)Heat shock protein 90 (Hsp90) is a protein chaperone that is upregulated and released from pancreatic β cells under pro-inflammatory conditions. We hypothesized that serum Hsp90 may have utility as a biomarker of type 1 ... -
Androgen-regulated transcription of ESRP2 drives alternative splicing patterns in prostate cancer
(ELife, 2019-09)Prostate is the most frequent cancer in men. Prostate cancer progression is driven by androgen steroid hormones, and delayed by androgen deprivation therapy (ADT). Androgens control transcription by stimulating androgen ... -
Antigen-specific immunotherapy with thyrotropin receptor peptides in Grave's Hyperthyroidism: a Phase I study
(Mary Ann Liebert, 2019-07)Graves' disease is one of the most common autoimmune conditions, but treatment remains imperfect. This study explores the first-in-human use of antigen-specific immunotherapy with a combination of two thyrotropin receptor ... -
Application of the DILEMMA score to improve lesion selection for invasive physiological assessment.
(Wiley, 2019-09-01)We sought to assess the validity of the DILEMMA score against instantaneous wave-free ratio (iFR) and evaluate its utility in rationalizing the number of patients referred for invasive physiological assessment. -
Are children with unrecognised psychiatric disorders being excluded from school? A secondary analysis of the British Child and Adolescent Mental Health Surveys 2004 and 2007
(Cambridge University Press, 2019-11)Background: There is limited research that explores the association between exclusion from school and mental health, but it seems intuitively plausible that the recognition of mental difficulties by key teachers and parents ... -
Arterial wall shear rate response to reactive hyperaemia is markedly different between young and older humans
(Wiley, 2019-08)Key points: The vasodilatory response to reactive hyperaemia is impaired with advancing age, but it is unclear whether this is because of an altered wall shear rate (WSR) stimulus or an altered flow-mediated dilatation ... -
Arthroscopy of the symptomatic shoulder arthroplasty
(Elsevier, 2019-10)Assessment of a painful or stiff shoulder arthroplasty can be challenging. The cause of pain can sometimes be easily identified. However, some patients have normal levels of inflammatory markers, normal plain films, and ... -
Assessing Patient-Centred Outcomes in Lateral Elbow Tendinopathy: A Systematic Review and Standardised Comparison of English Language Clinical Rating Systems
(Springer, 2019-03)Lateral elbow tendinopathy (LET) is a common condition affecting adults. Although a lack of treatment consensus continues to prompt numerous effectiveness studies, there is a paucity of clear guidance on the choice of ... -
Assessing the Pathogenicity, Penetrance, and Expressivity of Putative Disease-Causing Variants in a Population Setting
(Elsevier, 2019-02-07)More than 100,000 genetic variants are classified as disease causing in public databases. However, the true penetrance of many of these rare alleles is uncertain and might be over-estimated by clinical ascertainment. Here, ...