2019 RD&E publications
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A summary list of all RD&E research outputs published or issued in 2019
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Tip of the Iceberg: Assessing the Global Socioeconomic Costs of Alzheimer's Disease and Related Dementias and Strategic Implications for Stakeholders
(IOS Press, 2019)While it is generally understood that Alzheimer's disease (AD) and related dementias (ADRD) is one of the costliest diseases to society, there is widespread concern that researchers and policymakers are not comprehensively ... -
Epigenome-wide Association Study of Attention-Deficit/Hyperactivity Disorder Symptoms in Adults
(Elsevier Science, 2019-10-15)Background: Previous studies have reported associations between attention-deficit/hyperactivity disorder symptoms and DNA methylation in children. We report the first epigenome-wide association study meta-analysis of adult ... -
Interventions to improve the mental health of children and young people with long-term physical conditions: linked evidence syntheses
(NIHR Journals Library, 2019-05)Background: Although mental health difficulties can severely complicate the lives of children and young people (CYP) with long-term physical conditions (LTCs), there is a lack of evidence about the effectiveness of ... -
The Incidence of Recorded Delirium Episodes Before and After Dementia Diagnosis: Differences Between Dementia With Lewy Bodies and Alzheimer's Disease
(Elsevier Science, 2019-05)Objectives: To describe the incidence of delirium recording before and after a diagnosis of dementia is established in patients with dementia with Lewy bodies (DLB) and compare findings to a matched cohort of patients with ... -
Telomere length and aging-related outcomes in humans: A Mendelian randomization study in 261,000 older participants
(Wiley, 2019-12)Inherited genetic variation influencing leukocyte telomere length provides a natural experiment for testing associations with health outcomes, more robust to confounding and reverse causation than observational studies. ... -
Mild Behavioral Impairment as a Marker of Cognitive Decline in Cognitively Normal Older Adults
(Elsevier Science, 2019-08)Objective: Mild behavioral impairment (MBI) is a neurobehavioral syndrome characterized by later life emergent neuropsychiatric symptoms (NPS) that represent an at-risk state for incident cognitive decline and dementia in ... -
Pimavanserin in Alzheimer's Disease Psychosis: Efficacy in Patients with More Pronounced Psychotic Symptoms
(Springer, 2019)Background: Pimavanserin is a 5-HT2A receptor inverse agonist/antagonist and is approved in the United States for the treatment of hallucinations and delusions associated with Parkinson's disease psychosis. Objective: ... -
The Effect of a Multicomponent Intervention on Quality of Life in Residents of Nursing Homes: A Randomized Controlled Trial (COSMOS)
(Elsevier Science, 2019-03)Objectives: To investigate if the multicomponent intervention of the COSMOS trial, combining communication, systematic pain management, medication review, and activities, improved quality of life (QoL) in nursing home ... -
Arterial wall shear rate response to reactive hyperaemia is markedly different between young and older humans
(Wiley, 2019-08)Key points: The vasodilatory response to reactive hyperaemia is impaired with advancing age, but it is unclear whether this is because of an altered wall shear rate (WSR) stimulus or an altered flow-mediated dilatation ... -
Are children with unrecognised psychiatric disorders being excluded from school? A secondary analysis of the British Child and Adolescent Mental Health Surveys 2004 and 2007
(Cambridge University Press, 2019-11)Background: There is limited research that explores the association between exclusion from school and mental health, but it seems intuitively plausible that the recognition of mental difficulties by key teachers and parents ... -
A dynamical systems model for the measurement of cellular senescence
(Atypon, 2019-10-31)Senescent cells provide a good in vitro model to study ageing. However, cultures of 'senescent' cells consist of a mix of cell subtypes (proliferative, senescent, growth-arrested and apoptotic). Determining the proportion ... -
A novel combinatorial technique for simultaneous quantification of oxygen radicals and aggregation reveals unexpected redox patterns in the activation of platelets by different physiopathological stimuli
(Pagepress Publications, 2019-09)he regulation of platelets by oxidants is critical for vascular health and may explain thrombotic complications in diseases such as diabetes and dementia, but remains poorly understood. Here, we describe a novel technique ... -
The maximal metabolic steady state: redefining the 'gold standard'
(Wiley, 2019-05)The maximal lactate steady state (MLSS) and the critical power (CP) are two widely used indices of the highest oxidative metabolic rate that can be sustained during continuous exercise and are often considered to be ... -
Machine Learning in Aging Research
(Silverchair Information Systems, 2019-11-13) -
RNA sequencing of identical twins discordant for autism reveals blood-based signatures implicating immune and transcriptional dysregulation
(BioMed Central, 2019-11-07)Background: A gap exists in our mechanistic understanding of how genetic and environmental risk factors converge at the molecular level to result in the emergence of autism symptoms. We compared blood-based gene expression ... -
Treatment Combinations for Alzheimer's Disease: Current and Future Pharmacotherapy Options
(IOS Press, 2019)Although Alzheimer's disease (AD) is the world's leading cause of dementia and the population of patients with AD continues to grow, no new therapies have been approved in more than a decade. Many clinical trials of ... -
A combined immunodeficiency with severe infections, inflammation, and allergy caused by ARPC1B deficiency
(Elsevier Science, 2019-06) -
Hereditary spastic paraplegia: from diagnosis to emerging therapeutic approaches
(Elsevier Science, 2019-12)Hereditary spastic paraplegia (HSP) describes a heterogeneous group of genetic neurodegenerative diseases characterised by progressive spasticity of the lower limbs. The pathogenic mechanism, associated clinical features, ... -
Differential effects of saturated and unsaturated fatty acids on autophagy in pancreatic β-cells
(Sheridan PubFactory, 2019-11)Long-chain saturated fatty acids are lipotoxic to pancreatic β-cells, whereas most unsaturates are better tolerated and some may even be cytoprotective. Fatty acids alter autophagy in β-cells and there is increasing evidence ...