2019 RD&E publications

Tip of the Iceberg: Assessing the Global Socioeconomic Costs of Alzheimer's Disease and Related Dementias and Strategic Implications for Stakeholders

Ballard, Clive (IOS Press, 2019)

While it is generally understood that Alzheimer's disease (AD) and related dementias (ADRD) is one of the costliest diseases to society, there is widespread concern that researchers and policymakers are not comprehensively ...

Epigenome-wide Association Study of Attention-Deficit/Hyperactivity Disorder Symptoms in Adults

Hannon, Eilis; Mill, Jonathan (Elsevier Science, 2019-10-15)

Background: Previous studies have reported associations between attention-deficit/hyperactivity disorder symptoms and DNA methylation in children. We report the first epigenome-wide association study meta-analysis of adult ...

Interventions to improve the mental health of children and young people with long-term physical conditions: linked evidence syntheses

Moore, D. A.; Nunns, M.; Rogers, M.; Ford, T.; Garside, R.; Ukoumunne, O. C.; Anderson, R.; Dickens, C.; Logan, Stuart; Thompson Coon, J. (NIHR Journals Library, 2019-05)

Background: Although mental health difficulties can severely complicate the lives of children and young people (CYP) with long-term physical conditions (LTCs), there is a lack of evidence about the effectiveness of ...

The Incidence of Recorded Delirium Episodes Before and After Dementia Diagnosis: Differences Between Dementia With Lewy Bodies and Alzheimer's Disease

Ballard, Clive (Elsevier Science, 2019-05)

Objectives: To describe the incidence of delirium recording before and after a diagnosis of dementia is established in patients with dementia with Lewy bodies (DLB) and compare findings to a matched cohort of patients with ...

Telomere length and aging-related outcomes in humans: A Mendelian randomization study in 261,000 older participants

Pilling, L. C.; Melzer, David (Wiley, 2019-12)

Inherited genetic variation influencing leukocyte telomere length provides a natural experiment for testing associations with health outcomes, more robust to confounding and reverse causation than observational studies. ...

Mild Behavioral Impairment as a Marker of Cognitive Decline in Cognitively Normal Older Adults

Creese, Byron; Corbett, Anne; Ballard, Clive (Elsevier Science, 2019-08)

Objective: Mild behavioral impairment (MBI) is a neurobehavioral syndrome characterized by later life emergent neuropsychiatric symptoms (NPS) that represent an at-risk state for incident cognitive decline and dementia in ...

Pimavanserin in Alzheimer's Disease Psychosis: Efficacy in Patients with More Pronounced Psychotic Symptoms

Ballard, Clive (Springer, 2019)

Background: Pimavanserin is a 5-HT2A receptor inverse agonist/antagonist and is approved in the United States for the treatment of hallucinations and delusions associated with Parkinson's disease psychosis. Objective: ...

The Effect of a Multicomponent Intervention on Quality of Life in Residents of Nursing Homes: A Randomized Controlled Trial (COSMOS)

Ballard, Clive (Elsevier Science, 2019-03)

Objectives: To investigate if the multicomponent intervention of the COSMOS trial, combining communication, systematic pain management, medication review, and activities, improved quality of life (QoL) in nursing home ...

Arterial wall shear rate response to reactive hyperaemia is markedly different between young and older humans

Aizawa, Kunihiko; Casanova, Francesco; Thorn, Clare E.; Shore, Angela; Gates, Phillip E. (Wiley, 2019-08)

Key points: The vasodilatory response to reactive hyperaemia is impaired with advancing age, but it is unclear whether this is because of an altered wall shear rate (WSR) stimulus or an altered flow-mediated dilatation ...

Are children with unrecognised psychiatric disorders being excluded from school? A secondary analysis of the British Child and Adolescent Mental Health Surveys 2004 and 2007

Logan, Stuart (Cambridge University Press, 2019-11)

Background: There is limited research that explores the association between exclusion from school and mental health, but it seems intuitively plausible that the recognition of mental difficulties by key teachers and parents ...

A dynamical systems model for the measurement of cellular senescence

Harries, Lorna W. (Atypon, 2019-10-31)

Senescent cells provide a good in vitro model to study ageing. However, cultures of 'senescent' cells consist of a mix of cell subtypes (proliferative, senescent, growth-arrested and apoptotic). Determining the proportion ...

Hyperinsulinaemic hypoglycaemia: A new presentation of 16p11.2 deletion syndrome

Flanagan, Sarah (Wiley, 2019-05)

A novel combinatorial technique for simultaneous quantification of oxygen radicals and aggregation reveals unexpected redox patterns in the activation of platelets by different physiopathological stimuli

Pula, Giordano (Pagepress Publications, 2019-09)

he regulation of platelets by oxidants is critical for vascular health and may explain thrombotic complications in diseases such as diabetes and dementia, but remains poorly understood. Here, we describe a novel technique ...

The maximal metabolic steady state: redefining the 'gold standard'

Jones, Andrew M.; Black, Matthew I.; Vanhatalo, A. (Wiley, 2019-05)

The maximal lactate steady state (MLSS) and the critical power (CP) are two widely used indices of the highest oxidative metabolic rate that can be sustained during continuous exercise and are often considered to be ...

Machine Learning in Aging Research

Melzer, David (Silverchair Information Systems, 2019-11-13)

RNA sequencing of identical twins discordant for autism reveals blood-based signatures implicating immune and transcriptional dysregulation

Mill, Jonathan (BioMed Central, 2019-11-07)

Background: A gap exists in our mechanistic understanding of how genetic and environmental risk factors converge at the molecular level to result in the emergence of autism symptoms. We compared blood-based gene expression ...