2019 RD&E publications
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A summary list of all RD&E research outputs published or issued in 2019
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Royal Devon & Exeter NHS Foundation Trust publications - by specialty 2019
(Royal Devon & Exeter NHS Foundation Trust, 2020-06) -
Royal Devon & Exeter NHS Foundation Trust publications 2019
(Royal Devon & Exeter NHS Foundation Trust, 2020-06) -
Neuropsychological Assessment of mTBI in Adults
(Springer, 2019-11)Mild traumatic brain injury (mTBI), comprising 70–80% of all TBIs, is the commonest form of TBI, representing those injuries deemed to be at the lower end of the severity spectrum. In the general population, mTBI may occur ... -
POSU: A pilot study looking into the feasibility, safety and efficacy of a post-operative surgical unit for high-risk patients
(Sage, 2019-12)In this ambitious quality improvement project, we investigated the possibility of using operating theatre post-operative recovery ward to care for high-risk patients overnight. -
Bigmelon: Tools for Analysing Large DNA Methylation Datasets
(Oxford Academic, 2019-03)The datasets generated by DNA methylation analyses are getting bigger. With the release of the HumanMethylationEPIC micro-array and datasets containing thousands of samples, analyses of these large datasets using R are ... -
Persistent C-peptide secretion in Type 1 diabetes and its relationship to the genetic architecture of diabetes
(Biomed Central, 2019-08)The objective of this cross-sectional study was to explore the relationship of detectable C-peptide secretion in type 1 diabetes to clinical features and to the genetic architecture of diabetes. -
Genomic variant sharing: a position statement
(Wellcome, 2019-02)Sharing de-identified genetic variant data via custom-built online repositories is essential for the practice of genomic medicine and is demonstrably beneficial to patients. Robust genetic diagnoses that inform medical ... -
Growth disrupting mutations in epigenetic regulatory molecules are associated with abnormalities of epigenetic aging
(CSHL Press, 2019-07)Germline mutations in fundamental epigenetic regulatory molecules including DNA methyltransferase 3 alpha (DNMT3A) are commonly associated with growth disorders, whereas somatic mutations are often associated with malignancy. ... -
Patterns of postmeal insulin secretion in individuals with sulfonylurea- treated KCNJ11 neonatal diabetes show predominance of non- KATP- channel pathways
(BMJ, 2019-12)Insulin secretion in sulfonylurea-treated KCNJ11 permanent neonatal diabetes mellitus (PNDM) is thought to be mediated predominantly through amplifying non-KATP-channel pathways such as incretins. Affected individuals ... -
Hereditary Hemochromatosis Associations with Frailty, Sarcopenia and Chronic Pain: Evidence from 200,975 Older UK Biobank Participants
(Oxford Academic, 2019-02)Iron is essential for life but contributes to oxidative damage. In Northern-European ancestry populations, HFE gene C282Y mutations are relatively common (0.3%-0.6% rare homozygote prevalence) and associated with excessive ... -
What influences the sustainability of an effective psychosocial intervention for people with dementia living in care homes? A 9 to 12‐month follow‐up of the perceptions of staff in care homes involved in the WHELD randomised controlled trail
(Wiley, 2019-05)The study aims to understand the factors that care home staff felt enabled or hindered them in continuing to use the well-being and health for people with dementia (WHELD) psychosocial approach in their care home and ... -
Management of Behavioral and Psychological Symptoms in People With Alzheimer's Disease: An International Delphi Consensus
(Cambridge University Press, 2019-01)Behavioral and psychological symptoms of dementia (BPSD) are nearly universal in dementia, a condition occurring in more than 40 million people worldwide. BPSD present a considerable treatment challenge for prescribers and ... -
Vitamin D Levels and Risk of Delirium: A Mendelian Randomization Study in the UK Biobank
(Neurology, 2019-03)Objective: To estimate effects of vitamin D levels on incident delirium hospital admissions using inherited genetic variants in mendelian randomization models, which minimize confounding and exclude reverse causation. -
Genome-wide Association Analysis of Self-Reported Daytime Sleepiness Identifies 42 Loci That Suggest Biological Subtypes
(Nature, 2019-08)Excessive daytime sleepiness (EDS) affects 10-20% of the population and is associated with substantial functional deficits. Here, we identify 42 loci for self-reported daytime sleepiness in GWAS of 452,071 individuals from ... -
Systematic underestimation of the epigenetic clock and age acceleration in older subjects.
(Biomed Central, 2019-12)The Horvath epigenetic clock is widely used. It predicts age quite well from 353 CpG sites in the DNA methylation profile in unknown samples and has been used to calculate "age acceleration" in various tissues and environments. -
Cutaneous Leishmaniasis in a globetrotting explorer
(BMJ, 2019-12) -
Variants in the fetal genome near pro-inflammatory cytokine genes on 2q13 associate with gestational duration
(Nature, 2019-09)The duration of pregnancy is influenced by fetal and maternal genetic and non-genetic factors. Here we report a fetal genome-wide association meta-analysis of gestational duration, and early preterm, preterm, and postterm ... -
A longitudinal study of epileptic seizures in Alzheimer's Disease
(Frontiers in Neurology, 2019-12)The prevalence of epileptic seizures is increased in patients in the clinical stages of Alzheimer's disease (AD) when compared to age-matched cognitively normal populations. In previously reported work from the Presentation ... -
Multicomponent hospital-led interventions to reduce hospital stay for older adults following elective surgery: a systematic review
(National Institute of Health Research, 2019-12)Background: Elective older adult inpatient admissions are increasingly common. Older adults are at an elevated risk of adverse events in hospital, potentially increasing with lengthier hospital stay. Hospital-led ...
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