• An online investigation of the relationship between the frequency of word puzzle use and cognitive function in a large sample of older adults 

  Ballard, Clive; Corbett, Anne (Wiley, 2019-07)

  Objective: The identification of modifiable lifestyle factors to preserve cognitive function in older individuals becomes increasingly of importance. This study examines whether word puzzle use is related to cognitive ...

• The relationship between the frequency of number-puzzle use and baseline cognitive function in a large online sample of adults aged 50 and over 

  Ballard, Clive; Corbett, Anne (Wiley, 2019-07)

  Objective: Establishing affordable lifestyle interventions that might preserve cognitive function in the aging population and subsequent generations is a growing area of research focus. Data from the PROTECT study has been ...

• Methylation age acceleration does not predict mortality in schizophrenia 

  Hannon, Eilis; Mansell, Georgina; Burrage, Joe; Mill, Jonathan (Nature Publishing Group, 2019-06-04)

  Schizophrenia (SCZ) is associated with high mortality. DNA methylation levels vary over the life course, and pre-selected combinations of methylation array probes can be used to estimate "methylation age" (mAge). mAge ...

• Clinical spectrum of POLR3-related leukodystrophy caused by biallelic POLR1C pathogenic variants 

  Rankin, Julia (Wolters Kluwer Health, 2019-10-30)

  Objective: To determine the clinical, radiologic, and molecular characteristics of RNA polymerase III-related leukodystrophy (POLR3-HLD) caused by biallelic POLR1C pathogenic variants. Methods: A cross-sectional observational ...

• Robotic Management of Endometriosis: Discussion of Use, Criteria and Advantages: a Review of the Literature 

  Gkegkes, Ioannis D. (DDS on behalf of Universitas Carolina, 2019)

  Endometriosis is a very common benign condition affecting fertility and quality of life. Different methods, either definitive or fertility sparing are used for its management by using open, laparoscopic, and robotic ...

• Early recurrence and the need for re-resection following Photodynamic diagnosis–assisted Transurethral Resection of Bladder Tumours: Multi-centre real-world experience of the UK PDD Users Group 

  Crundwell, Malcolm (Sage, 2019-12-31)

  Abstract Objective: This study aimed to investigate the association between Photodynamic Diagnosis (PDD) with hexaminolevulinate (HAL) and the rate of complete resection and disease persistence at first follow-up cystoscopy ...

• Survival time and differences between dementia with Lewy bodies and Alzheimer's disease following diagnosis: A meta-analysis of longitudinal studies 

  Ballard, Clive (Elsevier, 2019-03)

  Objective To synthesize the evidence across longitudinal studies comparing survival in dementia with Lewy bodies (DLB) and Alzheimer’s disease (AD). Methods We conducted a systematic review and meta-analysis of studies ...

• Establishing a generalized polyepigenetic biomarker for tobacco smoking 

  Hannon, Eilis; Mill, Jonathan (Springer Nature, 2019-02-15)

  Large-scale epigenome-wide association meta-analyses have identified multiple 'signatures'' of smoking. Drawing on these findings, we describe the construction of a polyepigenetic DNA methylation score that indexes smoking ...

• Generating evidence for new high-risk medical devices. 

  Campbell, Bruce (BMJ, 2019-09-04)

• No Surgical Innovation Without Evaluation: Evolution and Further Development of the IDEAL Framework and Recommendations 

  Campbell, Bruce (Wolters Kluwer, 2019-02)

  Abstract Objective: To update, clarify, and extend IDEAL concepts and recommendations. Background: New surgical procedures, devices, and other complex interventions need robust evaluation for safety, efficacy, and ...

• Long-term active surveillance of implantable medical devices: an analysis of factors determining whether current registries are adequate to expose safety and efficacy problems 

  Campbell, Bruce (BMJ, 2019-07-03)

• Royal Devon & Exeter NHS Foundation Trust publications - by specialty 2019 

  Newell, Cate (Royal Devon & Exeter NHS Foundation Trust, 2020-06)

• Royal Devon & Exeter NHS Foundation Trust publications 2019 

  Newell, Cate (Royal Devon & Exeter NHS Foundation Trust, 2020-06)

• Neuropsychological Assessment of mTBI in Adults 

  Yates, Philip J; Reuben, Adam (Springer, 2019-11)

  Mild traumatic brain injury (mTBI), comprising 70–80% of all TBIs, is the commonest form of TBI, representing those injuries deemed to be at the lower end of the severity spectrum. In the general population, mTBI may occur ...

• POSU: A pilot study looking into the feasibility, safety and efficacy of a post-operative surgical unit for high-risk patients 

  Baldwin, Matthew; McCormick, Bruce; Foale, Mark; Belete, Martha; Chen, Connie; Williams, Helen; Stark, David; Matthews, Ed (Sage, 2019-12)

  In this ambitious quality improvement project, we investigated the possibility of using operating theatre post-operative recovery ward to care for high-risk patients overnight.

• Mechanical thrombectomy for acute ischaemic stroke: challenges and opportunities 

  James, Martin (2019-11)

• Bigmelon: Tools for Analysing Large DNA Methylation Datasets 

  Mill, Jonathan (Oxford Academic, 2019-03)

  The datasets generated by DNA methylation analyses are getting bigger. With the release of the HumanMethylationEPIC micro-array and datasets containing thousands of samples, analyses of these large datasets using R are ...

• Persistent C-peptide secretion in Type 1 diabetes and its relationship to the genetic architecture of diabetes 

  McDonald, Timothy J. (Biomed Central, 2019-08)

  The objective of this cross-sectional study was to explore the relationship of detectable C-peptide secretion in type 1 diabetes to clinical features and to the genetic architecture of diabetes.

• Genomic variant sharing: a position statement 

  Wright, Caroline F; Ellard, Sian (Wellcome, 2019-02)

  Sharing de-identified genetic variant data via custom-built online repositories is essential for the practice of genomic medicine and is demonstrably beneficial to patients. Robust genetic diagnoses that inform medical ...

• Growth disrupting mutations in epigenetic regulatory molecules are associated with abnormalities of epigenetic aging 

  Mill, Jonathan; Crosby, Andrew H; Baple, Emma L (CSHL Press, 2019-07)

  Germline mutations in fundamental epigenetic regulatory molecules including DNA methyltransferase 3 alpha (DNMT3A) are commonly associated with growth disorders, whereas somatic mutations are often associated with malignancy. ...

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