• Are children with unrecognised psychiatric disorders being excluded from school? A secondary analysis of the British Child and Adolescent Mental Health Surveys 2004 and 2007 

  Logan, Stuart (Cambridge University Press, 2019-11)

  Background: There is limited research that explores the association between exclusion from school and mental health, but it seems intuitively plausible that the recognition of mental difficulties by key teachers and parents ...

• A dynamical systems model for the measurement of cellular senescence 

  Harries, Lorna W. (Atypon, 2019-10-31)

  Senescent cells provide a good in vitro model to study ageing. However, cultures of 'senescent' cells consist of a mix of cell subtypes (proliferative, senescent, growth-arrested and apoptotic). Determining the proportion ...

• Hyperinsulinaemic hypoglycaemia: A new presentation of 16p11.2 deletion syndrome 

  Flanagan, Sarah (Wiley, 2019-05)

• A novel combinatorial technique for simultaneous quantification of oxygen radicals and aggregation reveals unexpected redox patterns in the activation of platelets by different physiopathological stimuli 

  Pula, Giordano (Pagepress Publications, 2019-09)

  he regulation of platelets by oxidants is critical for vascular health and may explain thrombotic complications in diseases such as diabetes and dementia, but remains poorly understood. Here, we describe a novel technique ...

• The maximal metabolic steady state: redefining the 'gold standard' 

  Jones, Andrew M.; Black, Matthew I.; Vanhatalo, A. (Wiley, 2019-05)

  The maximal lactate steady state (MLSS) and the critical power (CP) are two widely used indices of the highest oxidative metabolic rate that can be sustained during continuous exercise and are often considered to be ...

• Machine Learning in Aging Research 

  Melzer, David (Silverchair Information Systems, 2019-11-13)

• RNA sequencing of identical twins discordant for autism reveals blood-based signatures implicating immune and transcriptional dysregulation 

  Mill, Jonathan (BioMed Central, 2019-11-07)

  Background: A gap exists in our mechanistic understanding of how genetic and environmental risk factors converge at the molecular level to result in the emergence of autism symptoms. We compared blood-based gene expression ...

• Treatment Combinations for Alzheimer's Disease: Current and Future Pharmacotherapy Options 

  Ballard, Clive (IOS Press, 2019)

  Although Alzheimer's disease (AD) is the world's leading cause of dementia and the population of patients with AD continues to grow, no new therapies have been approved in more than a decade. Many clinical trials of ...

• A combined immunodeficiency with severe infections, inflammation, and allergy caused by ARPC1B deficiency 

  Maroofian, R. (Elsevier Science, 2019-06)

• Hereditary spastic paraplegia: from diagnosis to emerging therapeutic approaches 

  Crosby, Andrew H. (Elsevier Science, 2019-12)

  Hereditary spastic paraplegia (HSP) describes a heterogeneous group of genetic neurodegenerative diseases characterised by progressive spasticity of the lower limbs. The pathogenic mechanism, associated clinical features, ...

• Differential effects of saturated and unsaturated fatty acids on autophagy in pancreatic β-cells 

  Dhayal, S.; Welters, Hannah J.; Morgan, Noel G. (Sheridan PubFactory, 2019-11)

  Long-chain saturated fatty acids are lipotoxic to pancreatic β-cells, whereas most unsaturates are better tolerated and some may even be cytoprotective. Fatty acids alter autophagy in β-cells and there is increasing evidence ...

• What the HLA-I!-Classical and Non-classical HLA Class I and Their Potential Roles in Type 1 Diabetes 

  Wyatt, R. C.; Richardson, S. J. (Springer, 2019-12-09)

  Purpose of review: Hyperexpression of classical HLA class I (HLA-I) molecules in insulin-containing islets has become a widely accepted hallmark of type 1 diabetes pathology. In comparison, relatively little is known about ...

• Outcome of acute pancreatitis in octogenarians: A retrospective study 

  Di Mauro, Davide; Wijesurendere, Chinthaka; Attanasio, Andrea; Elkhuffash, Iyad; Ricciardi, Edoardo; Wajed, Shahjehan; Manzelli, Antonio (Wiley, 2019-11-14)

  Background and aim: Acute pancreatitis (AP) is a common disease, but data on outcomes in octogenarians are scarce in the literature. The aim of this study is to analyze results from patients aged 80 years old and over who ...

• Pharmacological treatment for Type 2 diabetes integrating findings from cardiovascular outcome trials: an expert consensus in the UK 

  Strain, W David (Wiley, 2019-09)

  In people with Type 2 diabetes, cardiovascular disease is a leading cause of morbidity and mortality. Thus, as well as controlling glucose, reducing the risk of cardiovascular events is a key goal. The results of cardiovascular ...

• The acute transcriptional response to resistance exercise: impact of age and contraction mode 

  Deane, Colleen S. (Impact Journals, 2019-04-15)

  Optimization of resistance exercise (RE) remains a hotbed of research for muscle building and maintenance. However, the interactions between the contractile components of RE (i.e. concentric (CON) and eccentric (ECC)) and ...

• Age-related neurochemical and behavioural changes in D409V/WT GBA1 mouse: Relevance to lewy body dementia 

  Ballard, Clive (Elsevier Science, 2019-10)

  Heterozygous mutations in GBA1, the gene which encodes the lysosomal enzyme glucocerebrosidase (GCase), are a strong genetic risk factor for the development of Lewy body dementia (LBD). Until this point however, recapitulation ...

• Obesity and Longer Term Risks of Dementia in 65-74 Year Olds 

  Melzer, David (Oxford University Press, 2019-05-01)

  Background: overweight or obesity at ages <65 years associates with increased dementia incidence, but at ≥65 years estimates are paradoxical. Weight loss before dementia diagnosis, plus smoking and diseases causing weight ...

• Commentary: Opportunities for Combination Trials 

  Ballard, Clive (Springer, 2019)

• Genomics of 1 million parent lifespans implicates novel pathways and common diseases and distinguishes survival chances 

  Frayling, Timothy; Yaghootkar, Hanieh (eLife Sciences Publications Ltd., 2019-01-15)

  We use a genome-wide association of 1 million parental lifespans of genotyped subjects and data on mortality risk factors to validate previously unreplicated findings near CDKN2B-AS1, ATXN2/BRAP, FURIN/FES, ZW10, PSORS1C3, ...

• Contralateral fatigue during severe-intensity single-leg exercise: influence of acute acetaminophen ingestion 

  Bailey, S. J.; Fulford, J.; Vanhatalo, A. (Atypon, 2019-08-01)

  Exhaustive single-leg exercise has been suggested to reduce time to task failure (Tlim) during subsequent exercise in the contralateral leg by exacerbating central fatigue development. We investigated the influence of ...

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