Factors affecting local regrowth after watch and wait for patients with a clinical complete response following chemoradiotherapy in rectal cancer (InterCoRe consortium): an individual participant data meta-analysis.
Chadi, S. A. [et al]
Daniels, Ian R.
Smart, Neil J.
JournalThe Lancet. Gastroenterology & Hepatology
RightsArchived with thanks to The lancet. Gastroenterology & hepatology
MetadataShow full item record
In patients with rectal cancer who achieve clinical complete response after neoadjuvant chemoradiotherapy, watch and wait is a novel management strategy with potential to avoid major surgery. Study-level meta-analyses have reported wide variation in the proportion of patients with local regrowth. We did an individual participant data meta-analysis to investigate factors affecting occurrence of local regrowth.