Now showing items 1-1 of 1

    • PDL1 is expressed in the islets of people with type 1 diabetes and is up-regulated by interferons-α and-γ via IRF1 induction. 

      Colli, M. L.; Hill, J. L. E.; Marroquí, L.; Chaffey, J.; Dos Santos, R. S.; Leete, P.; Coomans de Brachène, A.; Paula, F. M. M.; Op de Beeck, A.; Castela, A.; Marselli, L.; Krogvold, L.; Dahl-Jorgensen, K.; Marchetti, P.; Morgan, Noel; Richardson, S. J.; Eizirik, D. L. (Elsevier, 2018-09-27)
      Antibodies targeting PD-1 and its ligand PDL1 are used in cancer immunotherapy but may lead to autoimmune diseases, including type 1 diabetes (T1D). It remains unclear whether PDL1 is expressed in pancreatic islets of ...