Browsing 2018 RD&E publications by Issue Date
Now showing items 21-40 of 350
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Continuous Hyperfractionated Accelerated Radiotherapy (CHART) for Non-small Cell Lung Cancer (NSCLC): 7 Years' Experience From Nine UK Centres.
(Elsevier, 2018-01-11)Continuous hyperfractionated accelerated radiotherapy (CHART) remains an option to treat non-small cell lung cancer (NSCLC; NICE, 2011). We have previously published treatment outcomes from 1998-2003 across five UK centres. ... -
A meta-analysis of the utility of the neutrophil-to-lymphocyte ratio in predicting survival after pancreatic cancer resection.
(Elsevier, 2018-01-11)The neutrophil-to-lymphocyte ratio (NLR) is thought to reflect cancer disease burden. To assess the prognostic ability of the NLR on overall survival in patients with resectable, pancreatic cancer a meta-analysis of published ... -
Genetic mutations associated with neonatal diabetes mellitus in Omani patients.
(De Gruyter, 2018-01-12)Neonatal diabetes mellitus (NDM) is a rare disorder worldwide where diabetes is diagnosed in the first 6 months of life. However, Oman has a relatively high incidence of NDM. -
Response to: "High stoma prevalence and stoma reversal complications following anterior resection for rectal cancer: a population-based multicentre study".
(Wiley, 2018-01-12)We read with interest the article by Holmgren et al1 . There is no doubt that formation of a defunctioning stoma is a decision not to be taken lightly and we welcome research into ways in which we may be able to identify ... -
Analysis of DNA Methylation in Young People: Limited Evidence for an Association Between Victimization Stress and Epigenetic Variation in Blood.
(American Psychiatric Association, 2018-01-12)DNA methylation has been proposed as an epigenetic mechanism by which early-life experiences become "embedded" in the genome and alter transcriptional processes to compromise health. The authors sought to investigate whether ... -
Molecular Pathways for Immune Recognition of Preproinsulin Signal Peptide in Type 1 Diabetes.
(American Diabetes Association, 2018-01-17)The signal peptide region of preproinsulin (PPI) contains epitopes targeted by human leucocyte antigen-A (HLA-A)-restricted (HLA-A0201, A2402) cytotoxic T-cells as part of the pathogenesis of β-cell destruction in type 1 ... -
Chronic obstructive pulmonary disease guidelines in Europe: a look into the future.
(BioMed Central, 2018-01-18)Clinical practice guidelines are ubiquitous and are developed to provide recommendations for the management of many diseases, including chronic obstructive pulmonary disease. The development of these guidelines is burdensome, ... -
Open radical cystectomy in England: the current standard of care - an analysis of the BAUS cystectomy audit and HES data.
(Wiley, 2018-01-23)Data entry by surgeons performing radical cystectomy to the BAUS database was mandated in 2013. Combining this with HES data has allowed comprehensive outcome analysis for the first time. The aim of this study was to ... -
Introduction into the NHS of magnetic sphincter augmentation: an innovative surgical therapy for reflux - results and challenges.
(Royal College of Surgeons, 2018-01-24)Introduction Gastro-oesophageal reflux disease (GORD) is a common, chronic debilitating condition. Surgical management traditionally involves fundoplication. Magnetic sphincter augmentation (MSA) is a new definitive ... -
Intravascular lymphoma presenting with postural hypotension.
(BMJ, 2018-01-29)An 84-year-old woman presented with severe postural hypotension. Further assessment revealed weight loss, fatigue and fever at night. On examination, she had bilateral skin lesions on the inner thighs and skin biopsy ... -
An audit of urological MDT decision making in the South West of England
(Sage, 2018-01-30)The formation of multidisciplinary teams (MDTs) was formalised for urological cancer services by the National Institute for Health and Care Excellence (NICE) in the 2002 Improving Outcomes in Urological Cancer guidance. ... -
Exocrine pancreatic dysfunction is common in hepatocyte nuclear factor 1β–associated renal disease and can be symptomatic
(Oxford Journals, 2018-01-30) -
MAFA missense mutation causes familial insulinomatosis and diabetes mellitus.
(Proceedings of the National Academy of Sciences of the USA, 2018-01-30)The β-cell-enriched MAFA transcription factor plays a central role in regulating glucose-stimulated insulin secretion while also demonstrating oncogenic transformation potential in vitro. No disease-causing MAFA variants ... -
What is the evidence for the use of biologic or biosynthetic meshes in abdominal wall reconstruction?
(Springer, 2018-01-31)Although many surgeons have adopted the use of biologic and biosynthetic meshes in complex abdominal wall hernia repair, others have questioned the use of these products. Criticism is addressed in several review articles ... -
Airway and ventilation management strategies for haemorrhagic shock. To tube, or not to tube, that is the question!
(Wolters Kluwer, 2018-01-31)Many standard trauma management guidelines advocate the early use of endotracheal intubation and positive pressure ventilation as key treatment interventions in haemorrhagic shock. The evidence for using these airway and ... -
Tumour risks and genotype-phenotype correlations associated with germline variants in succinate dehydrogenase subunit genesSDHB,SDHCandSDHD.
(BMJ, 2018-01-31)Germline pathogenic variants inSDHB/SDHC/SDHDare the most frequent causes of inherited phaeochromocytomas/paragangliomas. Insufficient information regarding penetrance and phenotypic variability hinders optimum management ... -
Precision Medicine in Type 2 Diabetes: Clinical Markers of Insulin Resistance Are Associated With Altered Short- and Long-Term Glycemic Response to DPP-4 Inhibitor Therapy.
(American Diabetes Association, 2018-01-31)A precision approach to type 2 diabetes therapy would aim to target treatment according to patient characteristics. We examined if measures of insulin resistance and secretion were associated with glycemic response to ... -
Touching the void - First and third person perspectives in two cases of autobiographical amnesia linked to temporal lobe epilepsy.
(Elsevier, 2018-02)Temporal lobe epilepsy (TLE) can be associated with a marked impairment of autobiographical memory. This is occasionally its presenting feature. We describe two individuals with severe epilepsy-associated autobiographical ... -
A case report of squamous cell carcinoma in a suprapubic urinary catheter tract: surgical excision and simultaneous colostomy formation.
(Oxford Academic, 2018-02)Squamous cell carcinoma (SCC) arising from a suprapubic cystostomy tract is a rare complication of long-term suprapubic catheterization (SPC). A 53-year-old man with paraplegia secondary to spina bifida presented with a ... -
Healthy Parent Carers programme: development and feasibility of a novel group-based health-promotion intervention.
(BioMed Central, 2018-02)Parent carers of disabled children report poor physical health and mental wellbeing. They experience high levels of stress and barriers to engagement in health-related behaviours and with 'standard' preventive programmes ...