5-hydroxymethylcytosine is highly dynamic across human fetal brain development.
Author
Spiers, H.
Hannon, E.
Schalkwyk, L. C.
Bray, N. J.
Mill, Jonathan
Date
2017-09-18Journal
BMC genomicsType
Journal ArticlePublisher
BioMed CentralDOI
10.1186/s12864-017-4091-xRights
Archived with thanks to BMC genomicsMetadata
Show full item recordAbstract
Epigenetic processes play a key role in orchestrating transcriptional regulation during the development of the human central nervous system. We previously described dynamic changes in DNA methylation (5mC) occurring during human fetal brain development, but other epigenetic processes operating during this period have not been extensively explored. Of particular interest is DNA hydroxymethylation (5hmC), a modification that is enriched in the human brain and hypothesized to play an important role in neuronal function, learning and memory. In this study, we quantify 5hmC across the genome of 71 human fetal brain samples spanning 23 to 184 days post-conception.