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    5-hydroxymethylcytosine is highly dynamic across human fetal brain development.

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    URI
    http://hdl.handle.net/11287/620420
    Author
    Spiers, H.
    Hannon, E.
    Schalkwyk, L. C.
    Bray, N. J.
    Mill, Jonathan
    Date
    2017-09-18
    Journal
    BMC genomics
    Type
    Journal Article
    Publisher
    BioMed Central
    DOI
    10.1186/s12864-017-4091-x
    Rights
    Archived with thanks to BMC genomics
    Metadata
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    Abstract
    Epigenetic processes play a key role in orchestrating transcriptional regulation during the development of the human central nervous system. We previously described dynamic changes in DNA methylation (5mC) occurring during human fetal brain development, but other epigenetic processes operating during this period have not been extensively explored. Of particular interest is DNA hydroxymethylation (5hmC), a modification that is enriched in the human brain and hypothesized to play an important role in neuronal function, learning and memory. In this study, we quantify 5hmC across the genome of 71 human fetal brain samples spanning 23 to 184 days post-conception.
    Citation
    5-hydroxymethylcytosine is highly dynamic across human fetal brain development. 2017, 18 (1):738 BMC Genomics
    Publisher URL
    https://bmcgenomics.biomedcentral.com/articles/10.1186/s12864-017-4091-x
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    • 2017 RD&E publications
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