Islet cell hyperexpression of HLA class I antigens: a defining feature in type 1 diabetes.

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Authors
Richardson, S. J.
Rodriguez-Calvo, T.
Gerling, I. C.
Mathews, C. E.
Kaddis, J. S.
Russell, M. A.
Zeissler, M.
Leete, P.
Krogvold, L.
Dahl-Jørgensen, K.
Journal
Diabetologia
Type
Journal Article
Publisher
Springer
Rights
Archived with thanks to Diabetologia
Human pancreatic beta cells may be complicit in their own demise in type 1 diabetes, but how this occurs remains unclear. One potentially contributing factor is hyperexpression of HLA class I antigens. This was first described approximately 30 years ago, but has never been fully characterised and was recently challenged as artefactual. Therefore, we investigated HLA class I expression at the protein and RNA levels in pancreases from three cohorts of patients with type 1 diabetes. The principal aims were to consider whether HLA class I hyperexpression is artefactual and, if not, to determine the factors driving it.
Citation
Islet cell hyperexpression of HLA class I antigens: a defining feature in type 1 diabetes. 2016, 59 (11):2448-58 Diabetologia
Note
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