DNA Methylation Profiling in Inflammatory Bowel Disease Provides New Insights into Disease Pathogenesis.
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Authors
McDermott, E.
Ryan, E.J.
Tosetto, M.
Gibson, D.
Burrage, Joe
Keegan, D.
Byrne, K.
Crowe, E.
Sexton, G.
Malone, K.
Journal
Journal of Crohn's & colitis
Type
Comparative Study
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Publisher
Oxford Academic
Rights
Archived with thanks to Journal of Crohn's & colitis
Inflammatory bowel diseases (IBDs) are heterogeneous disorders with complex aetiology. Quantitative genetic studies suggest that only a small proportion of the disease variance observed in IBD is accounted for by genetic variation, indicating a potential role for differential epigenetic regulation in disease aetiology. The aim of this study was to assess genome-wide DNA methylation changes specifically associated with ulcerative colitis (UC), Crohn's disease (CD) and IBD activity.
Citation
DNA Methylation Profiling in Inflammatory Bowel Disease Provides New Insights into Disease Pathogenesis. 2016, 10 (1):77-86 J Crohns Colitis
Note
This article is freely available via Open Access. Click on the ‘Additional Link’ above to access the full-text from the publisher’s site.