DNA Methylation Profiling in Inflammatory Bowel Disease Provides New Insights into Disease Pathogenesis.
Author
McDermott, E.
Ryan, E.J.
Tosetto, M.
Gibson, D.
Burrage, Joe
Keegan, D.
Byrne, K.
Crowe, E.
Sexton, G.
Malone, K.
Harris, R.A.
Kellermayer, R.
Mill, Jonathan
Cullen, G.
Doherty, G.A.
Mulcahy, H.
Murphy, Therese M.
Date
2016-01Journal
Journal of Crohn's & colitisType
Comparative StudyResearch Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Publisher
Oxford AcademicDOI
10.1093/ecco-jcc/jjv176Rights
Archived with thanks to Journal of Crohn's & colitisMetadata
Show full item recordAbstract
Inflammatory bowel diseases (IBDs) are heterogeneous disorders with complex aetiology. Quantitative genetic studies suggest that only a small proportion of the disease variance observed in IBD is accounted for by genetic variation, indicating a potential role for differential epigenetic regulation in disease aetiology. The aim of this study was to assess genome-wide DNA methylation changes specifically associated with ulcerative colitis (UC), Crohn's disease (CD) and IBD activity.