DNA Methylation Profiling in Inflammatory Bowel Disease Provides New Insights into Disease Pathogenesis.

McDermott, E.; Ryan, E.J.; Tosetto, M.; Gibson, D.; Burrage, Joe; Keegan, D.; Byrne, K.; Crowe, E.; Sexton, G.; Malone, K.; Harris, R.A.; Kellermayer, R.; Mill, Jonathan; Cullen, G.; Doherty, G.A.; Mulcahy, H.; Murphy, Therese M.

URI

http://hdl.handle.net/11287/620262

Author

McDermott, E.

Ryan, E.J.

Tosetto, M.

Gibson, D.

Burrage, Joe

Keegan, D.

Byrne, K.

Crowe, E.

Sexton, G.

Malone, K.

Harris, R.A.

Kellermayer, R.

Mill, Jonathan

Cullen, G.

Doherty, G.A.

Mulcahy, H.

Murphy, Therese M.

Date

2016-01

Journal

Journal of Crohn's & colitis

Type

Comparative Study
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Publisher

Oxford Academic

DOI

10.1093/ecco-jcc/jjv176

Rights

Archived with thanks to Journal of Crohn's & colitis

Metadata

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Abstract

Inflammatory bowel diseases (IBDs) are heterogeneous disorders with complex aetiology. Quantitative genetic studies suggest that only a small proportion of the disease variance observed in IBD is accounted for by genetic variation, indicating a potential role for differential epigenetic regulation in disease aetiology. The aim of this study was to assess genome-wide DNA methylation changes specifically associated with ulcerative colitis (UC), Crohn's disease (CD) and IBD activity.

Citation

DNA Methylation Profiling in Inflammatory Bowel Disease Provides New Insights into Disease Pathogenesis. 2016, 10 (1):77-86 J Crohns Colitis

Publisher URL

https://academic.oup.com/ecco-jcc/article-lookup/doi/10.1093/ecco-jcc/jjv176

Note

This article is freely available via Open Access. Click on the ‘Additional Link’ above to access the full-text from the publisher’s site.