Browsing 2017 RD&E publications by Title
Now showing items 1-20 of 326
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3-phase Technicium-99m bone scanning in patients with pain in the hip region after cemented total hip replacement: a multicentre series of 100 cases.
(Wichtig, 2017-11-21)The aim of this study was to assess the benefit of a Technetium-99M (HDP) 3-phase bone scan (TPBS) as an additional diagnostic test in the evaluation of pain in the hip region following cemented total hip replacement (THR) ... -
5-hydroxymethylcytosine is highly dynamic across human fetal brain development.
(BioMed Central, 2017-09-18)Epigenetic processes play a key role in orchestrating transcriptional regulation during the development of the human central nervous system. We previously described dynamic changes in DNA methylation (5mC) occurring during ... -
Abiraterone for Prostate Cancer Not Previously Treated with Hormone Therapy.
(New England Journal of Medicine, 2017-07)Abiraterone acetate plus prednisolone improves survival in men with relapsed prostate cancer. We assessed the effect of this combination in men starting long-term androgen-deprivation therapy (ADT), using a multigroup, ... -
An Activating STAT3 Mutation Causes Neonatal Diabetes through Premature Induction of Pancreatic Differentiation.
(Cell Press, 2017-04-11)Activating germline mutations in STAT3 were recently identified as a cause of neonatal diabetes mellitus associated with beta-cell autoimmunity. We have investigated the effect of an activating mutation, STAT3(K392R), on ... -
Acute appendicitis
(Elsevier, 2017-08)Appendicitis is defined as inflammation of the vermiform appendix, the most common surgical emergency in children and young adults with abdominal pain. The current standard of care for patients with appendicitis is the ... -
Acute gastric outlet obstruction secondary to exclusive paraoesophageal small bowel herniation: a case report.
(Taylor & Francis, 2017-04-19)Herniation of abdominal viscera into the thorax may occur as a consequence of abnormal defects in the diaphragm. In adults, the most common condition relates to herniations through a weakened crural orifice via which the ... -
Addition of gemcitabine to paclitaxel, epirubicin, and cyclophosphamide adjuvant chemotherapy for women with early-stage breast cancer (tAnGo): final 10-year follow-up of an open-label, randomised, phase 3 trial.
(Elsevier, 2017-06)The tAnGo trial was designed to investigate the potential role of gemcitabine when added to anthracycline and taxane-containing adjuvant chemotherapy for early breast cancer. When this study was developed, gemcitabine had ... -
Adipose tissue is influenced by hypoxia of obstructive sleep apnea syndrome independent of obesity.
(Elsevier Masson, 2017-01-25)Obstructive sleep apnea syndrome (OSAS) is associated with increased cardiovascular risk and diabetes independent of obesity. We investigated whether adipose tissue dysfunction is exacerbated due to increased tissue hypoxia. -
Adjunctive rifampicin for Staphylococcus aureus bacteraemia (ARREST): a multicentre, randomised, double-blind, placebo-controlled trial.
(Elsevier, 2017-12-14)Staphylococcus aureus bacteraemia is a common cause of severe community-acquired and hospital-acquired infection worldwide. We tested the hypothesis that adjunctive rifampicin would reduce bacteriologically confirmed ... -
Adolescent patellar instability: current concepts review.
(British Editorial Society of Bone and Joint Journal, 2017-02)Patellar instability most frequently presents during adolescence. Congenital and infantile dislocation of the patella is a distinct entity from adolescent instability and measurable abnormalities may be present at birth. ... -
Advanced paternal age effects in neurodevelopmental disorders-review of potential underlying mechanisms.
(Nature, 2017-01-31)Multiple epidemiological studies suggest a relationship between advanced paternal age (APA) at conception and adverse neurodevelopmental outcomes in offspring, particularly with regard to increased risk for autism and ... -
An alternative sensor-based method for glucose monitoring in children and young people with diabetes.
(BMJ, 2017-01-30)To determine accuracy, safety and acceptability of the FreeStyle Libre Flash Glucose Monitoring System in the paediatric population. -
An Amish founder mutation disrupts a PI(3)P-WHAMM-Arp2/3 complex-driven autophagosomal remodeling pathway.
(American Society for Cell Biology, 2017-09-15)Actin nucleation factors function to organize, shape, and move membrane-bound organelles, yet they remain poorly defined in relation to disease. Galloway-Mowat syndrome (GMS) is an inherited disorder characterized by ... -
Amplatzer Vascular Plug 4 Insertion for the Treatment of a Left Subclavian Artery Pseudoaneurysm.
(Elsevier, 2017-05-04)We report the case of a 74-year-old male with an incidental finding of a pseudoaneurysm at the base of his neck arising from the left subclavian artery. Initial treatment with ultrasound-guided thrombin injection was ... -
The Anaesthetic Management of a Compromised Airway Secondary to Lemierre’s Syndrome
(MedCrave, 2017-12-11)Lemierre’s syndrome is a life threatening soft tissue infection of the neck. We describe the anaesthetic management of a patient presenting with a compromised airway due to severe soft tissue swelling associated with ... -
Anaesthetic management of patients requiring vascular access surgery for renal dialysis
(Oxford Journals, 2017-08) -
Analysis of cell-free fetal DNA for non-invasive prenatal diagnosis in a family with neonatal diabetes.
(Wiley, 2017-04)An early genetic diagnosis of neonatal diabetes guides clinical management and results in improved treatment in ~ 40% of patients. In the offspring of individuals with neonatal diabetes, a prenatal diagnosis allows accurate ... -
ANK1 is up-regulated in laser captured microglia in Alzheimer's brain; the importance of addressing cellular heterogeneity.
(PLoS One, 2017-07)Recent epigenetic association studies have identified a new gene, ANK1, in the pathogenesis of Alzheimer's disease (AD). Although strong associations were observed, brain homogenates were used to generate the data, introducing ...