Browsing 2017 RD&E publications by Issue Date
Now showing items 1-20 of 326
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Infection Control Nurses Association' to Infection Prevention Society: 10 years on.
(Journal of Infection Control, 2016-09) -
Mercaptopurine versus placebo to prevent recurrence of Crohn's disease after surgical resection (TOPPIC): a multicentre, double-blind, randomised controlled trial.
(Elsevier, 2016-12)Up to 60% of patients with Crohn's disease need intestinal resection within the first 10 years of diagnosis, and postoperative recurrence is common. We investigated whether mercaptopurine can prevent or delay postoperative ... -
Measurement of VO2max in clinical groups is feasible and necessary
(American Physiological Society, 2017) -
Promotion of exercise in the management of cystic fibrosis - summary of national meetings
(European Society of Person Centered Healthcare, 2017) -
Mirrored stainless steel substrate provides improved signal for Raman spectroscopy of tissue and cells.
(Wiley, 2017-01)Raman spectroscopy (RS) is a powerful technique that permits the non-destructive chemical analysis of cells and tissues without the need for expensive and complex sample preparation. To date, samples have been routinely ... -
Expanding role of the internet in the orthopaedic outpatient setting
(Royal College of Surgeons, 2017-01)The number of patients requiring review after joint arthroplasty is increasing. With an ageing population, increasing expectations from patients, and improved diagnostic methods and treatments, the demand for these procedures ... -
Defining drug response for stratified medicine.
(Elsevier, 2017-01)The premise for stratified medicine is that drug efficacy, drug safety, or both, vary between groups of patients, and biomarkers can be used to facilitate more targeted prescribing, with the aim of improving the benefit:risk ... -
Considerations for management of patients with diabetic macular edema: optimizing treatment outcomes and minimizing safety concerns through interdisciplinary collaboration
(Elsevier, 2017-01)Diabetes is a growing worldwide epidemic and a leading cause of blindness in working-age people around the world. Diabetic retinopathy (DR) and diabetic macular edema (DME) are common causes of visual impairment in people ... -
Integrative genomic analysis implicates limited peripheral adipose storage capacity in the pathogenesis of human insulin resistance
(Nature, 2017-01)Insulin resistance is a key mediator of obesity-related cardiometabolic disease, yet the mechanisms underlying this link remain obscure. Using an integrative genomic approach, we identify 53 genomic regions associated with ... -
Manipulation of oxygen and endoplasmic reticulum stress factors as possible interventions for treatment of multiple sclerosis: evidence for and against.
(Springer, 2017-01)Multiple sclerosis (MS) is normally considered a chronic inflammatory disease of the central nervous system (CNS), where T-cells breaching the blood brain barrier react against proteins of the axonal myelin sheaths, leading ... -
Streptococcal Toxic Shock Syndrome Caused by Group G Streptococcus , United Kingdom
(Centers for Disease Control & Prevention, 2017-01)We describe successful management of 3 patients with streptococcal toxic shock syndrome (STSS) attributable to group G Streptococcus infection. This small series supports recognition of group G Streptococcus in the etiology ... -
Mutations in HYAL2, Encoding Hyaluronidase 2, Cause a Syndrome of Orofacial Clefting and Cor Triatriatum Sinister in Humans and Mice.
(PLoS, 2017-01)Orofacial clefting is amongst the most common of birth defects, with both genetic and environmental components. Although numerous studies have been undertaken to investigate the complexities of the genetic etiology of this ... -
Subclinical hypothyroidism: Should we treat?
(Taylor & Francis, 2017-01-01)Subclinical hypothyroidism (also known as compensated hypothyroidism or mild hypothyroidism) is a condition associated with a raised serum concentration of thyroid stimulating hormone (TSH) but a normal serum free thyroxine ... -
GLP-1 analogue-induced weight loss does not improve obesity-induced AT dysfunction
(Portland Press, 2017-01-03)Glucagon-like peptide-1 (GLP-1) analogues aid weight loss which improves obesity-associated adipose tissue (AT) dysfunction. GLP-1 treatment may however also directly influence AT which expresses GLP-1 receptors. This study ... -
A mutation of EPT1 (SELENOI) underlies a new disorder of Kennedy pathway phospholipid biosynthesis.
(Oxford Journals, 2017-01-03)Mutations in genes involved in lipid metabolism have increasingly been associated with various subtypes of hereditary spastic paraplegia, a highly heterogeneous group of neurodegenerative motor neuron disorders characterized ... -
Methylomic profiling of cortex samples from completed suicide cases implicates a role for PSORS1C3 in major depression and suicide
(Nature, 2017-01-03)Major depressive disorder (MDD) represents a major social and economic health issue and constitutes a major risk factor for suicide. The molecular pathology of suicidal depression remains poorly understood, although it has ... -
Case report: maternal mosaicism resulting in inheritance of a novel GATA6 mutation causing pancreatic agenesis and neonatal diabetes mellitus.
(BioMed Central, 2017-01-03)Haploinsufficiency of the GATA6 transcription factor gene was recently found to be the most common cause of pancreatic agenesis, a rare cause of neonatal diabetes mellitus. Although most cases are de novo, we describe three ... -
‘Not a Plastic Surgeon’s best friend: Dog bites an increasing burden on UK Plastic Surgery services’
(Elsevier, 2017-01-08)Injuries from dog bites are increasing in the United Kingdom (UK). Our study aims to highlight the public health burden of dog bites within the United Kingdom, in particular to the plastic and reconstructive surgeon. ... -
Do we have the right PROMs for measuring outcomes in lumbar spinal surgery?
(Springer, 2017-01-09)Patient-reported outcome measures (PROMs) have become an important part of routine auditing of outcomes in spinal surgery in the UK. PROMs can be used to help assess the quality of care provided by surgical units by ... -
Genome-wide association study implicates immune activation of multiple integrin genes in inflammatory bowel disease.
(Nature, 2017-01-09)Genetic association studies have identified 215 risk loci for inflammatory bowel disease, thereby uncovering fundamental aspects of its molecular biology. We performed a genome-wide association study of 25,305 individuals ...