Combined treatment with regulatory T cells and vascularized bone marrow transplantation creates mixed chimerism and induces donor-specific tolerance to vascularized composite allografts without cytoreductive conditioning

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Authors
Lin, J-Y
Tsai, F-C
Wallace, Christopher G
Huang, W-C
Wei, F-C
Liao, S-K
Journal
Journal of Surgical Research
Type
Journal Article
Publisher
Elsevier
Rights
Archived with thanks to Journal of Surgical Research
Cotreatment with regulatory T cells (T(reg)) and conventional allogeneic bone marrow transplantation (BMT) successfully induced durable chimerism and tolerance to nonvascularized skin allografts without cytoreductive conditioning in mice. We sought to determine whether T(reg) treatment combined with vascularized BMT (VBMT) could create mixed chimerism and induce tolerance to vascularized composite allografts (VCAs) without cytoreductive conditioning in rats.
Citation
Combined treatment with regulatory T cells and vascularized bone marrow transplantation creates mixed chimerism and induces donor-specific tolerance to vascularized composite allografts without cytoreductive conditioning 2012, 178 (2):974 Journal of Surgical Research
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