A high prevalence of glucokinase mutations in gestational diabetic subjects selected by clinical criteria.
Author
Ellard, Sian
Beards, F.
Allen, Louisa
Shepherd, Maggie
Ballantyne, E.
Harvey, R.
Hattersley, Andrew T.
Date
2000-02Journal
DiabetologiaType
Research Support, Non-U.S. Gov'tPublisher
SpringerDOI
10.1007/s001250050038Rights
Archived with thanks to DiabetologiaMetadata
Show full item recordAbstract
Patients with glucokinase mutations are characterised by mild, persistent fasting hyperglycaemia, a small increment in glucose in response to an oral load and a dominant family history. These patients frequently present with gestational diabetes and often require insulin treatment during pregnancy. We assessed whether the selection of gestational diabetic subjects by clinical criteria would result in a high detection rate of glucokinase mutations.