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    Intrauterine hyperglycemia is associated with an earlier diagnosis of diabetes in HNF-1alpha gene mutation carriers.

    Thumbnail
    URI
    http://hdl.handle.net/11287/619510
    Author
    Stride, A.
    Shepherd, Maggie
    Frayling, T. M.
    Bulman, Mike P
    Ellard, Sian
    Hattersley, Andrew T.
    Date
    2002-12
    Journal
    Diabetes care
    Type
    Research Support, Non-U.S. Gov't
    Publisher
    Highwire
    Rights
    Archived with thanks to Diabetes care
    Metadata
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    Abstract
    In animals, experimentally induced maternal hyperglycemia during pregnancy results in hyperglycemic offspring. Similarly, Pima Indian offspring with mothers who are diabetic at the time of pregnancy have increased risk of early-onset diabetes. We hypothesized that exposure to hyperglycemia in utero would decrease the age at diagnosis of diabetes in patients with maturity-onset diabetes of the young (MODY) due to a mutation in the hepatocyte nuclear factor 1alpha (HNF-1alpha) gene.
    Citation
    Intrauterine hyperglycemia is associated with an earlier diagnosis of diabetes in HNF-1alpha gene mutation carriers. 2002, 25 (12):2287-91 Diabetes Care
    Publisher URL
    http://care.diabetesjournals.org/content/25/12/2287.long
    Note
    RD&E staff can access the full-text of this article via OpenAthens. Click on the 'Additional Link' above to access the full-text and log in with NHS OpenAthens if prompted.
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    • Diabetes and endocrinology
    • Genetics and genomics
    • pre-2014 RD&E publications

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