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    Beta-cell dysfunction, insulin sensitivity, and glycosuria precede diabetes in hepatocyte nuclear factor-1alpha mutation carriers.

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    URI
    http://hdl.handle.net/11287/619275
    Author
    Stride, A.
    Ellard, Sian
    Clark, P.
    Shakespeare, L.
    Salzmann, Maurice B.
    Shepherd, Maggie
    Hattersley, Andrew T.
    Date
    2005-07
    Journal
    Diabetes care
    Type
    Research Support, Non-U.S. Gov't
    Publisher
    Highwire
    Rights
    Archived with thanks to Diabetes care
    Metadata
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    Abstract
    Patients with diabetes due to hepatocyte nuclear factor (HNF)-1alpha mutations have beta-cell deficiency, insulin sensitivity, altered proinsulin levels, and a low renal threshold for glucose. It is uncertain how many of these features precede the development of diabetes. The aim of our study was to test for these characteristics in young nondiabetic HNF-1alpha mutation carriers.
    Citation
    Beta-cell dysfunction, insulin sensitivity, and glycosuria precede diabetes in hepatocyte nuclear factor-1alpha mutation carriers. 2005, 28 (7):1751-6 Diabetes Care
    Publisher URL
    http://care.diabetesjournals.org/content/28/7/1751.long
    Note
    RD&E staff can access the full-text of this article via OpenAthens. Click on the 'Additional Link' above to access the full-text and log in with NHS OpenAthens if prompted.
    Collections
    • Clinical Genetics (Peninsula Genetics)
    • Exeter Clinical Laboratory International (Blood Sciences, Genetics, Cellular Pathology & Microbiology)
    • pre-2014 RD&E publications

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