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    A genetic diagnosis of HNF1A diabetes alters treatment and improves glycaemic control in the majority of insulin-treated patients.

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    URI
    http://hdl.handle.net/11287/619260
    Author
    Shepherd, Maggie
    Shields, Beverley
    Ellard, Sian
    Rubio-Cabezas, O.
    Hattersley, Andrew T.
    Date
    2009-04
    Journal
    Diabetic medicine : a journal of the British Diabetic Association
    Type
    Research Support, N.I.H., Extramural
    Research Support, Non-U.S. Gov't
    Publisher
    Wiley
    DOI
    10.1111/j.1464-5491.2009.02690.x
    Rights
    Archived with thanks to Diabetic medicine : a journal of the British Diabetic Association
    Metadata
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    Abstract
    Hepatocyte nuclear factor-1 alpha (HNF1A) gene mutations are the commonest cause of monogenic diabetes, but patients are often misdiagnosed as having Type 1 diabetes and started on insulin treatment. Patients with HNF1A diabetes are particularly sensitive to the glucose-lowering effect of sulphonylureas, which are the pharmacological treatment of choice. We aimed to assess if patients do change from insulin to sulphonylurea treatment when HNF1A diabetes is confirmed and the impact of this treatment change on long-term glycaemic control.
    Citation
    A genetic diagnosis of HNF1A diabetes alters treatment and improves glycaemic control in the majority of insulin-treated patients. 2009, 26 (4):437-41 Diabet. Med.
    Publisher URL
    http://onlinelibrary.wiley.com/doi/10.1111/j.1464-5491.2009.02690.x/abstract?systemMessage=Wiley+Online+Library+will+be+unavailable+on+Saturday+3rd+September+2016+at+08.30+BST%2F+03%3A30+EDT%2F+15%3A30+SGT+for+5+hours+and+Sunday+4th+September+at+10%3A00+BST%2F+05%3A00+EST%2F+17%3A00+SGT+for+1+hour++for+essential+maintenance.+Apologies+for+the+inconvenience
    Note
    This article is freely available via Open Access. Click on the ‘Additional Link’ above to access the full-text from the publisher’s site.
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    • Diabetes and endocrinology
    • Genetics and genomics
    • Honorary contracts publications
    • pre-2014 RD&E publications

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