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    Urinary C-peptide creatinine ratio is a practical outpatient tool for identifying hepatocyte nuclear factor 1-{alpha}/hepatocyte nuclear factor 4-{alpha} maturity-onset diabetes of the young from long-duration type 1 diabetes.

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    URI
    http://hdl.handle.net/11287/619216
    Author
    Besser, R.
    Shepherd, Maggie
    McDonald, Timothy J.
    Shields, Beverley
    Knight, Bridget A.
    Ellard, Sian
    Hattersley, Andrew T.
    Date
    2011-02
    Journal
    Diabetes care
    Type
    Clinical Trial
    Research Support, Non-U.S. Gov't
    Publisher
    Highwire
    DOI
    10.2337/dc10-1293
    Rights
    Archived with thanks to Diabetes care
    Metadata
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    Abstract
    Hepatocyte nuclear factor 1-α (HNF1A)/hepatocyte nuclear factor 4-α (HNF4A) maturity-onset diabetes of the young (MODY) is frequently misdiagnosed as type 1 diabetes, and patients are inappropriately treated with insulin. Blood C-peptide can aid in the diagnosis of MODY, but practical reasons limit its widespread use. Urinary C-peptide creatinine ratio (UCPCR), a stable measure of endogenous insulin secretion, is a noninvasive alternative. We aimed to compare stimulated UCPCR in adults with HNF1A/4A MODY, type 1 diabetes, and type 2 diabetes.
    Citation
    Urinary C-peptide creatinine ratio is a practical outpatient tool for identifying hepatocyte nuclear factor 1-{alpha}/hepatocyte nuclear factor 4-{alpha} maturity-onset diabetes of the young from long-duration type 1 diabetes. 2011, 34 (2):286-91 Diabetes Care
    Publisher URL
    http://care.diabetesjournals.org/content/34/2/286.long
    Note
    RD&E staff can access the full-text of this article via OpenAthens. Click on the 'Additional Link' above to access the full-text and log in with NHS OpenAthens if prompted.
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