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    Use of HbA1c in the identification of patients with hyperglycaemia caused by a glucokinase mutation: observational case control studies.

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    URI
    http://hdl.handle.net/11287/619208
    Author
    Steele, A. M.
    Wensley, K. J.
    Ellard, Sian
    Murphy, R.
    Shepherd, Maggie
    Colclough, K.
    Hattersley, Andrew T.
    Shields, Beverley
    Date
    2013
    Journal
    PloS one
    Type
    Observational Study
    Research Support, Non-U.S. Gov't
    Publisher
    PLoS One
    DOI
    10.1371/journal.pone.0065326
    Rights
    Archived with thanks to PloS one
    Metadata
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    Abstract
    HaemoglobinA1c (HbA1c) is recommended for diabetes diagnosis but fasting plasma glucose (FPG) has been useful for identifying patients with glucokinase (GCK) mutations which cause lifelong persistent fasting hyperglycaemia. We aimed to derive age-related HbA1c reference ranges for these patients to determine how well HbA1c can discriminate patients with a GCK mutation from unaffected family members and young-onset type 1 (T1D) and type 2 diabetes (T2D) and to investigate the proportion of GCK mutation carriers diagnosed with diabetes using HbA1c and/or FPG diagnostic criteria.
    Citation
    Use of HbA1c in the identification of patients with hyperglycaemia caused by a glucokinase mutation: observational case control studies. 2013, 8 (6):e65326 PLoS ONE
    Publisher URL
    http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0065326
    Note
    This article is freely available via Open Access. Click on the ‘Additional Link’ above to access the full-text from the publisher’s site.
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