Use of HbA1c in the identification of patients with hyperglycaemia caused by a glucokinase mutation: observational case control studies.

Steele, A. M.; Wensley, K. J.; Ellard, Sian; Murphy, R.; Shepherd, Maggie; Colclough, K.; Hattersley, Andrew T.; Shields, Beverley

URI

http://hdl.handle.net/11287/619208

Author

Steele, A. M.

Wensley, K. J.

Ellard, Sian

Murphy, R.

Shepherd, Maggie

Colclough, K.

Hattersley, Andrew T.

Shields, Beverley

Date

2013

Journal

PloS one

Type

Observational Study
Research Support, Non-U.S. Gov't

Publisher

PLoS One

DOI

10.1371/journal.pone.0065326

Rights

Archived with thanks to PloS one

Metadata

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Abstract

HaemoglobinA1c (HbA1c) is recommended for diabetes diagnosis but fasting plasma glucose (FPG) has been useful for identifying patients with glucokinase (GCK) mutations which cause lifelong persistent fasting hyperglycaemia. We aimed to derive age-related HbA1c reference ranges for these patients to determine how well HbA1c can discriminate patients with a GCK mutation from unaffected family members and young-onset type 1 (T1D) and type 2 diabetes (T2D) and to investigate the proportion of GCK mutation carriers diagnosed with diabetes using HbA1c and/or FPG diagnostic criteria.

Citation

Use of HbA1c in the identification of patients with hyperglycaemia caused by a glucokinase mutation: observational case control studies. 2013, 8 (6):e65326 PLoS ONE

Publisher URL

http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0065326

Note

This article is freely available via Open Access. Click on the ‘Additional Link’ above to access the full-text from the publisher’s site.