Validation of a single-sample urinary C-peptide creatinine ratio as a reproducible alternative to serum C-peptide in patients with Type 2 diabetes.
McDonald, Timothy J.
Knight, Bridget A.
Hattersley, Andrew T.
JournalDiabetic medicine : a journal of the British Diabetic Association
Research Support, Non-U.S. Gov't
RightsArchived with thanks to Diabetic medicine : a journal of the British Diabetic Association
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Serum C-peptide can be used in Type 2 diabetes as a measure of endogenous insulin secretion, but practicalities of collection limit its routine clinical use. Urine C-peptide creatinine ratio is a non-invasive alternative that is stable for at least 3 days at room temperature in boric acid preservative. We aimed to assess the utility of urine C-peptide creatinine ratio in individuals with Type 2 diabetes as an alternative to serum C-peptide.