The impact of insulin administration during the mixed meal tolerance test.
Author
Besser, R.
Jones, Angus G.
McDonald, Timothy J.
Shields, Beverley
Knight, Bridget A.
Hattersley, Andrew T.
Date
2012-10Journal
Diabetic medicine : a journal of the British Diabetic AssociationType
Comparative StudyResearch Support, Non-U.S. Gov't
Publisher
WileyDOI
10.1111/j.1464-5491.2012.03649.xRights
Archived with thanks to Diabetic medicine : a journal of the British Diabetic AssociationMetadata
Show full item recordAbstract
The mixed meal tolerance test is the gold standard measure of endogenous insulin secretion. Practical issues limit the routine clinical use of this test, including omitting insulin prior to the ingestion of a high-carbohydrate liquid mixed meal, which can result in marked hyperglycaemia. We aimed to assess whether insulin omission is necessary during the mixed meal tolerance test and whether fasting C-peptide was a practical alternative to the test.