The impact of insulin administration during the mixed meal tolerance test.
Jones, Angus G.
McDonald, Timothy J.
Knight, Bridget A.
Hattersley, Andrew T.
JournalDiabetic medicine : a journal of the British Diabetic Association
Research Support, Non-U.S. Gov't
RightsArchived with thanks to Diabetic medicine : a journal of the British Diabetic Association
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The mixed meal tolerance test is the gold standard measure of endogenous insulin secretion. Practical issues limit the routine clinical use of this test, including omitting insulin prior to the ingestion of a high-carbohydrate liquid mixed meal, which can result in marked hyperglycaemia. We aimed to assess whether insulin omission is necessary during the mixed meal tolerance test and whether fasting C-peptide was a practical alternative to the test.