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    Genome-wide association study of sexual maturation in males and females highlights a role for body mass and menarche loci in male puberty.

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    URI
    http://hdl.handle.net/11287/618281
    Author
    Cousminer, D. L. [et al]
    Hattersley, Andrew T.
    Date
    2014-08-15
    Journal
    Human Molecular Genetics
    Type
    Journal Article
    Meta-Analysis
    Research Support, N.I.H., Extramural
    Research Support, Non-U.S. Gov't
    Publisher
    Oxford Journals
    DOI
    10.1093/hmg/ddu150
    Rights
    Archived with thanks to Human molecular genetics
    Metadata
    Show full item record
    Abstract
    Little is known about genes regulating male puberty. Further, while many identified pubertal timing variants associate with age at menarche, a late manifestation of puberty, and body mass, little is known about these variants' relationship to pubertal initiation or tempo. To address these questions, we performed genome-wide association meta-analysis in over 11 000 European samples with data on early pubertal traits, male genital and female breast development, measured by the Tanner scale. We report the first genome-wide significant locus for male sexual development upstream of myocardin-like 2 (MKL2) (P = 8.9 × 10(-9)), a menarche locus tagging a developmental pathway linking earlier puberty with reduced pubertal growth (P = 4.6 × 10(-5)) and short adult stature (p = 7.5 × 10(-6)) in both males and females. Furthermore, our results indicate that a proportion of menarche loci are important for pubertal initiation in both sexes. Consistent with epidemiological correlations between increased prepubertal body mass and earlier pubertal timing in girls, body mass index (BMI)-increasing alleles correlated with earlier breast development. In boys, some BMI-increasing alleles associated with earlier, and others with delayed, sexual development; these genetic results mimic the controversy in epidemiological studies, some of which show opposing correlations between prepubertal BMI and male puberty. Our results contribute to our understanding of the pubertal initiation program in both sexes and indicate that although mechanisms regulating pubertal onset in males and females may largely be shared, the relationship between body mass and pubertal timing in boys may be complex and requires further genetic studies.
    Citation
    Genome-wide association study of sexual maturation in males and females highlights a role for body mass and menarche loci in male puberty. 2014, 23 (16):4452-64 Hum. Mol. Genet.
    Publisher URL
    http://hmg.oxfordjournals.org/cgi/pmidlookup?view=long&pmid=24770850
    Note
    This article is freely available from the publisher's site. Click on the 'Additional Link' above to access the full text.
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