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Increased plasma incretin concentrations identifies a subset of patients with persistent congenital hyperinsulinism without KATP channel gene defects.

dc.contributor.authorShi, Y.en
dc.contributor.authorAvatapalle, H. B.en
dc.contributor.authorSkae, M. S.en
dc.contributor.authorPadidela, R.en
dc.contributor.authorNewbould, M.en
dc.contributor.authorRigby, L.en
dc.contributor.authorFlanagan, Sarahen
dc.contributor.authorEllard, Sianen
dc.contributor.authorRahier, J.en
dc.contributor.authorClayton, P. E.en
dc.contributor.authorDunne, M. J.en
dc.contributor.authorBanerjee, I.en
dc.contributor.authorCosgrove, K. E.en
dc.date.accessioned2016-08-10T10:29:17Z
dc.date.available2016-08-10T10:29:17Z
dc.date.issued2015-01
dc.identifier.citationIncreased plasma incretin concentrations identifies a subset of patients with persistent congenital hyperinsulinism without KATP channel gene defects. 2015, 166 (1):191-4 J. Pediatr.en
dc.identifier.issn1097-6833
dc.identifier.pmid25444530
dc.identifier.doi10.1016/j.jpeds.2014.09.019
dc.identifier.urihttp://hdl.handle.net/11287/618199
dc.description.abstractCongenital hyperinsulinism causes profound hypoglycemia, which may persist or resolve spontaneously. Among 13 children with congenital hyperinsulinism, elevated incretin hormone concentrations were detected in 2 with atypical, persistent disease. We suggest that incretin biomarkers may identify these patients, and that elevated hormone levels may contribute to their pathophysiology.en
dc.language.isoenen
dc.publisherElsevieren
dc.relation.urlhttp://linkinghub.elsevier.com/retrieve/pii/S0022-3476(14)00847-6en
dc.rightsArchived with thanks to The Journal of pediatricsen
dc.subjectWessex Classification Subject Headings::Oncology. Pathology.::Geneticsen
dc.subjectWessex Classification Subject Headings::Endocrinologyen
dc.titleIncreased plasma incretin concentrations identifies a subset of patients with persistent congenital hyperinsulinism without KATP channel gene defects.en
dc.typeJournal Articleen
dc.typeResearch Support, Non-U.S. Gov'ten
dc.identifier.journalThe Journal of Pediatricsen
dc.description.noteThis article is freely available via Open Access, click on the 'Additional Link' above to access the full text via the publisher's site.en
dc.description.funding098395/Wellcome Trust/United Kingdomen
dc.type.versionPublisheden


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