Increased plasma incretin concentrations identifies a subset of patients with persistent congenital hyperinsulinism without KATP channel gene defects.
Avatapalle, H. B.
Skae, M. S.
Clayton, P. E.
Dunne, M. J.
Cosgrove, K. E.
JournalThe Journal of Pediatrics
Research Support, Non-U.S. Gov't
RightsArchived with thanks to The Journal of pediatrics
MetadataShow full item record
Congenital hyperinsulinism causes profound hypoglycemia, which may persist or resolve spontaneously. Among 13 children with congenital hyperinsulinism, elevated incretin hormone concentrations were detected in 2 with atypical, persistent disease. We suggest that incretin biomarkers may identify these patients, and that elevated hormone levels may contribute to their pathophysiology.