Increased plasma incretin concentrations identifies a subset of patients with persistent congenital hyperinsulinism without KATP channel gene defects.
Author
Shi, Y.
Avatapalle, H. B.
Skae, M. S.
Padidela, R.
Newbould, M.
Rigby, L.
Flanagan, Sarah
Ellard, Sian
Rahier, J.
Clayton, P. E.
Dunne, M. J.
Banerjee, I.
Cosgrove, K. E.
Date
2015-01Journal
The Journal of PediatricsType
Journal ArticleResearch Support, Non-U.S. Gov't
Publisher
ElsevierDOI
10.1016/j.jpeds.2014.09.019Rights
Archived with thanks to The Journal of pediatricsMetadata
Show full item recordAbstract
Congenital hyperinsulinism causes profound hypoglycemia, which may persist or resolve spontaneously. Among 13 children with congenital hyperinsulinism, elevated incretin hormone concentrations were detected in 2 with atypical, persistent disease. We suggest that incretin biomarkers may identify these patients, and that elevated hormone levels may contribute to their pathophysiology.