Increased plasma incretin concentrations identifies a subset of patients with persistent congenital hyperinsulinism without KATP channel gene defects.
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Authors
Shi, Y.
Avatapalle, H. B.
Skae, M. S.
Padidela, R.
Newbould, M.
Rigby, L.
Flanagan, Sarah
Ellard, Sian
Rahier, J.
Clayton, P. E.
Journal
The Journal of Pediatrics
Type
Journal Article
Research Support, Non-U.S. Gov't
Research Support, Non-U.S. Gov't
Publisher
Elsevier
Rights
Archived with thanks to The Journal of pediatrics
Congenital hyperinsulinism causes profound hypoglycemia, which may persist or resolve spontaneously. Among 13 children with congenital hyperinsulinism, elevated incretin hormone concentrations were detected in 2 with atypical, persistent disease. We suggest that incretin biomarkers may identify these patients, and that elevated hormone levels may contribute to their pathophysiology.
Citation
Increased plasma incretin concentrations identifies a subset of patients with persistent congenital hyperinsulinism without KATP channel gene defects. 2015, 166 (1):191-4 J. Pediatr.
Note
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