Biological interpretation of genome-wide association studies using predicted gene functions.
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Authors
Pers, T. H.
Karjalainen, J.M.
Chan, Y.
Westra, H-J
Wood, A. R.
Yang, J
Lui, J. C.
Vedantam, S.
Gustafsson, S.
Esko, T.
Journal
Nature communications
Type
Journal Article
Research Support, N.I.H., Extramural
Research Support, N.I.H., Intramural
Research Support, Non-U.S. Gov't
Research Support, N.I.H., Extramural
Research Support, N.I.H., Intramural
Research Support, Non-U.S. Gov't
Publisher
Nature
Rights
Archived with thanks to Nature communications
The main challenge for gaining biological insights from genetic associations is identifying which genes and pathways explain the associations. Here we present DEPICT, an integrative tool that employs predicted gene functions to systematically prioritize the most likely causal genes at associated loci, highlight enriched pathways and identify tissues/cell types where genes from associated loci are highly expressed. DEPICT is not limited to genes with established functions and prioritizes relevant gene sets for many phenotypes.
Citation
Biological interpretation of genome-wide association studies using predicted gene functions. 2015, 6:5890 Nat Commun
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Note
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