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    New genetic loci link adipose and insulin biology to body fat distribution

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    URI
    http://hdl.handle.net/11287/618115
    Author
    Shungin, D. [et al]
    Hattersley, Andrew T.
    Frayling, Timothy M.
    Date
    2015-02-12
    Journal
    Nature
    Type
    Journal Article
    Meta-Analysis
    Publisher
    Nature
    DOI
    10.1038/nature14132
    Rights
    Archived with kind permission of Nature.
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    Abstract
    Body fat distribution is a heritable trait and a well-established predictor of adverse metabolic outcomes, independent of overall adiposity. To increase our understanding of the genetic basis of body fat distribution and its molecular links to cardiometabolic traits, here we conduct genome-wide association meta-analyses of traits related to waist and hip circumferences in up to 224,459 individuals. We identify 49 loci (33 new) associated with waist-to-hip ratio adjusted for body mass index (BMI), and an additional 19 loci newly associated with related waist and hip circumference measures (P < 5 × 10(-8)). In total, 20 of the 49 waist-to-hip ratio adjusted for BMI loci show significant sexual dimorphism, 19 of which display a stronger effect in women. The identified loci were enriched for genes expressed in adipose tissue and for putative regulatory elements in adipocytes. Pathway analyses implicated adipogenesis, angiogenesis, transcriptional regulation and insulin resistance as processes affecting fat distribution, providing insight into potential pathophysiological mechanisms.
    Citation
    New genetic loci link adipose and insulin biology to body fat distribution. 2015 Nature 518(7538):187-96
    Publisher URL
    http://www.ncbi.nlm.nih.gov/pmc/articles/pmid/25673412/
    Note
    This article is freely available via PubMed Central. Click on the 'Additional Link' above to access the full-text.
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    • 2015 RD&E publications
    • Diabetes and endocrinology
    • Honorary contracts publications

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